Sentences with phrase «sequence of a gene called»

Luckily, along came Armstead and his colleagues, who were working to precisely locate the sequence of a gene called staygreen (sgr) in the meadow grass Festuca pratensis, some variants of which remain green in drought and other unfavorable conditions because they are unable to break down a green pigment.

To solve the puzzle, he and Malaysian colleagues collected bits of the flower of Rafflesia keithii from Borneo and analyzed the DNA sequence of a gene called MatR.

Not exact matches

When looking into mechanisms that might affect the levels of SMN protein in neurons, the researchers scanned a genomic database called the UCSC Genome Browser and identified two genetic sequences that matched the opposite DNA strand of the SMN gene.

The DNA segments that carry genetic information are called genes, but other DNA sequences have structural purposes, or are involved in regulating the expression of genetic information.

Using Atlantic killifish (Fundulus heteroclitus), the researchers examined whether mitochondrial - nuclear interactions alter the frequency of alternative forms of a gene that arise by mutation, called alleles, for over 11,000 nuclear DNA sequence variations within a population of the fish with mixed ancestry.

«It's a type of molecule called an antisense oligonucleotide, or ASO, that essentially is synthetic string of nucleic acid that binds a specific sequence in the gene.»

A Canadian project called FORGE (finding of rare disease genes) aims to sequence children and families with 200 different disorders this year.

Lu's team will extract immune cells called T cells from the blood of the enrolled patients, and then use CRISPR — Cas9 technology — which pairs a molecular guide able to identify specific genetic sequences on a chromosome with an enzyme that can snip the chromosome at that spot — to knock out a gene in the cells.

These retroviral gene sequences make up about 8 per cent of the human genome, and are part of what is called non-coding DNA because they don't contain genetic instructions to make proteins.

Since the publication of the human genome sequence in 2001, scientists have found that the so - called junk DNA that lies between genes actually carries out many important functions.

So Axel Visel of the Lawrence Berkeley National Laboratory in California focused on «enhancers»: short sequences of DNA — which are still sometimes called «junk» — that do not code for genes but can influence their activity.

So to reveal their function, biologists used the sequence information along with a technique called RNA - mediated interference (RNAi) to temporarily inactivate each of nearly 17,000 of the worm's genes.

RNA sequencing of both single and clustered CTCs from breast cancer patients identified several genes expressed at elevated levels in CTC clusters, one of which — a protein called plakoglobin — also was overexpressed in the primary tumors of patients with reduced survival.

To deliver the healthy gene, the team inserted it into an engineered virus called adeno - associated virus 1, or AAV1, together with a promoter — a genetic sequence that turns the gene on only in certain sensory cells of the inner ear known as hair cells.

For one such project, the team developed a new software tool called GppFst that allows researchers to differentiate genetic drift — a neutral process whereby genes and gene sequences naturally change due to random mating within a population — from genetic variations that are indicative of evolutionary changes caused by natural selection.

As when he worked on the human genome, Venter is relying on a radical technique called shotgun sequencing: He chops up vast amounts of DNA into tiny pieces and then uses sophisticated computer analyzers to piece them back together into intelligible genes and chromosomes.

They identified a total of 164 barnacle larvae under a dissection microscope, extracted DNA from the larvae, and used standard techniques to sequence mitochondrial COI genes, often called a barcode sequence.

Another experiment looked at Arabidopsis containing a reporter gene called GUS that was fused to the regulatory sequences of the cytokinin receptor genes.

Different versions of genes can vary at single points in their sequence, and these variations are called SNPs.

Michael Metzker, at the time a graduate student in the laboratory of Richard Gibbs at Baylor College of Medicine in Houston, compared the gene sequences of the strains to see how closely related they were, using a technique called phylogenetic analysis.

It is true that a particular gene of an Avidian that evolved to perform the software operation called equals is complex in this sense — a specific, complex sequence of instructions produces the function.

The shared sequence included a gene called CNGA3, they report in the July issue of Nature Genetics.

The silk genes contain short stretches of DNA called motifs that vary between species in number and in their exact sequence.

To develop fluorescent in situ sequencing, scientists first fix in place thousands of RNAs — including working copies of genes called messenger RNAs — in cells, tissues, organs or embryos.

Using a technique called whole - genome random sequencing, a TIGR team mapped the entire two - million - gene sequence of Thermotoga maritima, a bacterium first plucked from hot geothermal springs in Vulcano, Italy.

Couch is part of an international consortium called ENIGMA that's working to sequence breast cancer genes from 40,000 cancer patients and healthy people.

The mouse atlas was produced using a method called «in situ hybridisation», in which thin slices of brain tissue are bathed in a solution containing molecular probes that bind to messenger RNA sequences produced by each gene.

A series of genetic analyses confirmed that the DNA target sequence had been altered in the transgenic plants, with either DNA insertions or deletions in both copies of the DFR - B gene (so - called bi-allellic mutants).

Double - stranded RNA can silence the expression of a gene with a corresponding sequence, a process called RNA interference (RNAi).

By performing DNA sequencing of more than 4,000 families affected by neurological problems, the two research teams independently discovered that a disease marked by reduced brain size and sensory and motor defects is caused by a mutation in a gene called CLP1, which is known to regulate tRNA metabolism in cells.

Although TIGR made most of the raw sequence data available in 1997, the team took several more years to finish the sequencing and characterize the genes, a process called annotation.

The genes that make the toxin proteins sit within a complex that has embedded within it a type of genomic sequence called a transposable element.

The mfd gene encodes a protein of 130 kilodaltons and contains the so - called «helicase motifs,» a leucine zipper motif, and regions of sequence similarity to UvrB and RecG proteins.

The team also carried out a so - called metagenomic analysis, in which the genomes from all organisms in a sample are sequenced collectively; the great majority of genes they found coded for proteins never seen before.

At the meeting, Tomas Walsh of the University of Washington, Seattle, reported on a test he and King developed, called BROCA, that sequences not only the BRCA genes, but also about 38 other cancer risk genes.

An entire class of proteins called transcription factors, which regulate the activity of certain genes by interacting with specific sequences of DNA, has largely been ignored by the pharmaceutical industry because it's difficult to design and screen drugs against them.

This short DNA sequence, called MBRE, was only able to carry out its function because it appeared in a region of this three - dimensional DNA where there was already a contact with genes from the HoxD group.

But another sequence, the gene's so - called unidentified domain (UD), appears to have changed extremely rapidly in humans — about seven times faster than it did in other mammals — and shows signs of being positively selected for in evolution.

To test their theory, the researchers investigated what would happen to fetal mouse brains if they interfered with Trnp1 expression using synthetic sequences of genetic material that silenced the gene, a technique called RNA interference.

These sequences in our DNA are often situated far away from the actual genes they regulate, in comparison to so called promoter regions, which traditionally have been considered to control most of the gene activity.

When zinc hooks up with a gene - controlling protein, it forms «zinc finger proteins» - so called because they can poke into the tight groove between the two strands of DNA and touch the sequence they're made for.

Explaining that Rick's gene sequencing had revealed a genetic condition called Hereditary Neuropathy with liability to Pressure Palsies (HNPP), the ClinSeq ® doctor asked if any of his brothers or sisters had it.

Two clock proteins, CLOCK (Circadian locomoter output cycles protein kaput) and BMAL1 (Brain and Muscle Arnt - like1) bind to each other to form a heterodimer complex, which then binds to a DNA sequence called E-box (CACGTG) located in the upper region of clock genes, Per (Period) and Cry (Cryptochrome), present in the genome.

The software, called DECoN, accurately and quickly detects changes in copy number of blocks of DNA called exons, by analysing sequencing data already generated to identify smaller gene changes.

Szabó and colleagues required a minimum of 10 sequence reads to call a gene as imprinted.

And doctors at the Great Ormond Street Hospital in London recently reported using a similar gene - editing technique called TALENs, which also recognizes and cuts precise DNA sequences, to engineer immune cells for a therapy that may have cured two infants of leukemia.

Berkeley Lab's Len Pennacchio (left) and Axel Visel led the development of a new technique for identifying gene enhancers called SIF - seq, for site - specific integration fluorescence - activated cell sorting followed by sequencing.

More recently, in a joint initiative with the BBMRI - LPC project (Biobanking and Biomolecular Resources Research Infrastructure — Large Prospective Cohorts) and the Wellcome Trust Sanger Institute, the CNAG - CRG launched a call to promote the use of sequencing technologies for the identification of novel causative variants and genes and to molecularly diagnose rare disease patients.

In 2014 the CNAG - CRG together with CIBERER launched a call to the Spanish research community offering free - of - charge Whole Exome Sequencing and bioinformatic analysis for disease gene identification in rare disorders.

Small stretches of about 22 nt non-coding RNA, so - called microRNA or miRNA, are important for gene regulation through its binding to coding RNA sequences.