By analyzing
the sequence of the growth factor, the scientists isolated a 22 - amino acid section that is responsible for the powerful binding of PIGF - 2 to extracellular matrix proteins.
Not exact matches
After deciphering this natural differentiation process, the investigators duplicated it in the laboratory dish by adding a
sequence of proteins, called
growth factors, to the fluid bathing the stem cells.
The final component in this long series
of signal
sequences is the Yorkie effector protein that is the decisive
factor at the end
of the Hippo signaling pathway and determines the start
of reactivation,
growth, and division in the stem cells.
Compared to their unmodified counterparts, the
growth factors containing the PIGF - 2
sequence resulted in much faster wound closing and production
of granulation tissue, and also led to a more pronounced new blood vessel formation, which is essential in sustaining the latter.
Sp1 binds to the GC - rich
sequence on the proximal region
of p21waf1 / cip1 promoter and acts as a mediator for the induction
of p21waf1 / cip1 gene caused by transforming
growth factor β (TGF - β; ref.