Sentences with phrase «sequence variation at»

Not exact matches

I marveled at a chart that showed a diagram of the tree of life, where relationships between different mammalian species were figured out solely by comparison of their DNA sequences, providing powerful support for Darwin's idea of descent from a common ancestor with natural selection operating on randomly occurring variations.

Age - related variations in DNA methylation were analyzed by deep sequencing technology, which revealed distinct patterns, with gains in methylation in older individuals occurring at genomic sites that were unmethylated in young individuals, and vice versa.

DNA polymorphism in the Y chromosome, examined at a 729 - base pair intron located immediately upstream of the ZFY zinc - finger exon, revealed no sequence variation in a worldwide sample of 38 human males.

Trent and others says that the same mechanism might be at work in genes linked to other cancers, such as breast and prostate cancer, which have been found to contain similar «harmless» sequence variations.

Different versions of genes can vary at single points in their sequence, and these variations are called SNPs.

Previous work had shown that two variations in the COX - 2 gene, with either a guanine (G) or a cytosine (C) molecule at a particular spot in the gene's DNA sequence, lead to different levels of COX - 2 protein.

Robert Cook - Deegan, director of the Institute for Genome Sciences and Policy at Duke University, does credit Myriad with discovering specific mutation sequences and building a public database of genetic variations — both valuable contributions.

UCSF [University of California, San Francisco]'s Institute for Human Genetics is participating, too, looking at genome - sequence variations.

Now back to those swallowtails: Grishin said their primary goal was really to devise a way to sequence genomes with high levels of genetic variation at a reasonable cost, but they were in for some surprises.

Genetic variation in antigenic, drug resistance, and pathogenesis determinants is abundant, consistent with an ancient origin of P. falciparum, whereas DNA variation at silent (synonymous) sites in coding sequences appears virtually absent, consistent with a recent origin of the parasite.

Because the genes help produce nicotine's buzz, a team led by Robert Weiss, a geneticist at the University of Utah in Salt Lake City, wanted to determine if variations in their sequences influence whether people develop a stronger addiction to cigarettes.

Looking at a protein modification that normally only exists in β - actin, they found that the reason it was not also present on γ - actin was due to variations in the coding sequence between the two actin genes.

We had high hopes for SNP arrays and GWAS, but as I discussed in my previous post, sequencing at large scale is required to uncover the full scope of genetic variation underlying complex phenotypes.

After looking at 9 million genetic variants in those who were asparagus anosmic, they linked this deficiency to 871 individual sequence variations they discovered in chromosome 1, on genes associated with our sense of smell.

The researchers, including Cleveland - based David Serre and Peter Zimmerman, Didier Menard (Institut Pasteur - Cambodia) and Arsene Ratsimbasoa (Madagascar National Malaria Control Program) are the first to sequence the genome of the parasite Plasmodium vivax, taken from patients at coverage needed to verify genome - wide DNA sequence variation.

PULLMAN — Researchers at Washington State University have identified a new class of DNA sequence variation in gene promoter regions that could help control the activity of genes.The novel variations, dubbed «multiple nucleotide length polymorphisms,» or MNLPs, altered transcription of the genes they were associated with as much as 11-fold.

From 2008 - 2010, he was supported by the CGGH to study phenotypic variation in the drug sensitivity of Plasmodium falciparum isolates collected Kilifi District, and to investigate genotype - phenotype associations using genome sequencing data generated on these isolates at the Wellcome Trust Sanger Institute.

A single DNA sequence is formed from a chain of four nucleotide bases and if some individuals in a population do not carry the same nucleotide at a specific position in the sequence, the variation is classified as an SNP.

Reykjavik, ICELAND, May 17, 2009 — In a paper published today in the online edition of Nature Genetics, scientists from deCODE genetics (Nasdaq: DCGN) and academic colleagues from Iceland, Denmark and the Netherlands present the discovery of single letter variations in the sequence of the human genome (SNPs) that influence the age of girls at menarche, the first menstrual period.

Reykjavik, ICELAND, January 10, 2010 — Scientists at deCODE genetics today report the discovery of seven novel and common single - letter variations in the sequence of the human genome (SNPs) that are involved in modulating the electrical impulses that govern the...

An international team led by researchers at the Broad Institute of MIT and Harvard, the Harvard T.H. Chan School of Public Health and Fred Hutchinson Cancer Research Center uncovered the influence of genetic variation on vaccine effectiveness after applying cutting - edge DNA sequencing technology to almost 5,000 patient blood samples.

Home > Press > Single - cell mRNA cytometry via sequence - specific nanoparticle clustering and trapping: Cell - to - cell variation in gene expression creates a need for techniques that can characterize expression at the level of individual cells

In a study published today, scientists at deCODE genetics use genomic and genealogical data from across the population of Iceland over many decades to show that people who carry sequence variations linked to higher levels of education have fewer children than average...

By utilizing paired genome - wide high - throughput DNA sequencing (DNA - seq) with RNA - seq, we found that gene dosage, at the level of individual genes or chromosomal «somy» (a general term covering disomy, trisomy, tetrasomy, etc.), accounted for greater than 85 % of total gene expression variation in genes with a 2-fold or greater change in expression.

Both of these cell line - associated XMRV genomes were found to exhibit a lower degree of intra-strain variation than previously reported for XMRV from 22Rv1 cells [20], with only 19 SNPs detected in the 22Rv1 - associated XMRV genome at the 3 % frequency cutoff by deep sequencing, and only 25 SNPs in the LNCaP - associated genome (Fig. 7A; Table S1).

REYKJAVIK, Iceland, 8 June 2015 — A study led by scientists at deCODE genetics and published today demonstrates at population scale that variations in the sequence of the genome that increase risk of mental illness characterized by psychosis are also predictors of creativity.

The beauty of this Y - shape molecule is that although the basic structure remains the same, millions of slight variations can be produced by changing the sequence of amino acids in the protein strands at the ends of the two arms of the «Y» molecule.

Your left leg is now in the same position as it was in the Supta Padangusthasana variation at the beginning of this sequence.

Of the admittedly short amount of time I could stomach playing, I was forced to repeatedly play terrible attempts at copying Left 4 Dead «s scavenger sequences, with every level I encountered featuring some variation of the «collect four things and bring them to the same place» objective.

There is a variation of Rudolph Zallinger's iconic «March of Progress» illustration that depicts the same progression with the addition of a final figure, hunched over a keyboard in front of a computer, its posture mirroring that of the ape at the beginning of the sequence.

At this point, researchers said, only a careful study of gene sequences and morphology can determine whether the source of the brown panda variation is in the air, the soil, or the shrinking genetic diversity of the giant pandas.