Sentences with phrase «sequence variation in»

Higher 5 - HTT CpG methylation, but not sequence variation in the serotonin transporter promoter region, exacerbates the effects of early life stress on behavioral stress reactivity.

Sequence variation in the 3 ′ - untranslated region of the dopamine transporter gene and attention - deficit / hyperactivity disorder (ADHD)

We used sequence variation in the mitochondrial COI gene to ask (i) whether cyamid population structures might reveal associations among right whale individuals and subpopulations, (ii) whether the divergences of the three nominally conspecific cyamid species on North Atlantic, North Pacific, and southern right whales (Euba.laena glac.ialis, Eubal.aena jap.onica, Euba.laena aust.ralis) might indicate their times of separation, and (iii) whether the shapes of cyamid gene trees might contain information about changes in the population sizes of right whales....

These isolates were invisible to the CDC diagnostic PCR assay in widespread current use, due to sequence variation in the primer binding site.

With more than 15 million entries in dbSNP, single nucleotide polymorphisms (SNPs) remain the most common form of DNA sequence variation in humans.

PULLMAN — Researchers at Washington State University have identified a new class of DNA sequence variation in gene promoter regions that could help control the activity of genes.The novel variations, dubbed «multiple nucleotide length polymorphisms,» or MNLPs, altered transcription of the genes they were associated with as much as 11-fold.

GenProfile focuses on the systematic analysis of DNA sequence variation in biomedically relevant genes in order to identify those variants, or combinations of variants (gene profiles), that determine an individual's genetic risk for disease, predict individually different drug response, and ultimately pave the way to a personalized medicine.

Dart - biopsy samples from 195 free - ranging African elephants in 21 populations were examined for DNA sequence variation in four nuclear genes (1732 base pairs).

DNA polymorphism in the Y chromosome, examined at a 729 - base pair intron located immediately upstream of the ZFY zinc - finger exon, revealed no sequence variation in a worldwide sample of 38 human males.

SNPs are the most common and abundant DNA sequence variations in genomes.

By comparing the sequences of these genes in healthy versus anorexic people, the team found that anorexic women consistently had particular sequence variations in two of these three genes.

Six distinct DNA sequence variations in EPM2A in nine families, and one homozygous microdeletion in another family, have been found to cosegregate with LD.

Identification of cis - regulatory sequence variations in individual genome sequences.

Not exact matches

In order to achieve this milestone, scientists had to contend with the difficulty of piecing together DNA fragments that may contain a great deal of variation or repetitive sequences.

biochemical evidence such as Cytochrome - cyto - C is just one of the thousands of sequences and is not proof of common ancestry, as there are more variations than similarities in the genetic code, on the other hand a study of the amino acid make - up reveals that man is closer to lamprey than are fish.

In theological terms I see Fowler's system or design as a variation of redemptive history with its chronological sequence of dispensations.

It can not be rushed: Not only can music not be rushed in the obvious sense — that is, it can not be rushed through, for it can survive only a relatively limited variation in speed before becoming unintelligible — it also can not be rushed over, in the sense that it depends intensely on sequences of tension and resolution.

Apparently these four episodes are put in sequence as variations on the theme that this is Israel's glorious hour only as it is God's glorious hour; that the word of Israel (that is, her overt, apparent nature and function as a people) becomes established against insuperable odds by the Word of the Lord (God's communicated or revealed nature and power and purpose) in mutually responsive interaction.

Age - related variations in DNA methylation were analyzed by deep sequencing technology, which revealed distinct patterns, with gains in methylation in older individuals occurring at genomic sites that were unmethylated in young individuals, and vice versa.

After gene - typing about 3,000 people, Sturm found that how OCA2 is expressed — and how much pigment a person has — is strongly linked to three single nucleotide polymorphisms (SNPs), or single letter variations, in a DNA sequence near the OCA2 gene.

More recently, it has become clear that slight variations in the regulatory sequences that determine when a gene is switched on,...

Next, he synthesised 50,000 DNA strands with sequences that almost matched parts of the 24 genes involved in lycopene production, but with a range of variations that he hoped would affect the amount of lycopene produced.

And in a separate study, researchers have already used the sequence to chart a surprising degree of genetic variation among women.

Naturally occurring peptides can be composed of 20 different amino acids, so there is a great deal of possible variation in their sequences.

Trent and others says that the same mechanism might be at work in genes linked to other cancers, such as breast and prostate cancer, which have been found to contain similar «harmless» sequence variations.

Thanks to PCR, scientists could amplify DNA in great volumes and thereby «read» the genetic sequences of all sorts of organisms in all their variations.

The genetic variation of individual DNA sequences in a population is called its genetic diversity.

The team integrated three, complementary gene sequencing approaches to look for mutations in tumor cells from SS patients: whole - genome sequencing in six subjects, sequencing of all protein - coding regions (exomes) in 66 subjects, and comparing variation in the number of copies of all genes across the genome in 80 subjects.

But he remains perplexed by the level of conservation — up to 100 % — in some of the sequences because biology often tolerates minor variations.

Slight variations of this problem appear in many other areas of research, such as DNA sequencing, moving an automated soldering tip to many soldering points, or routing packets of data through processing nodes.

They also compared the human genomes with recently sequenced genomes of Neanderthals and Denisovans and found similar genetic variation, which indicates that the facial variation in modern humans must have originated prior to the split between these different lineages.

Different versions of genes can vary at single points in their sequence, and these variations are called SNPs.

Previous work had shown that two variations in the COX - 2 gene, with either a guanine (G) or a cytosine (C) molecule at a particular spot in the gene's DNA sequence, lead to different levels of COX - 2 protein.

Despite the variation between the photos and the hand drawn maps, scientists were able to reconstruct and view the entire 45 m long sequence in 3D for the first time since excavation.

With the completion of the first phase of the Human Genome Project in 2000, and the advent of sequencing technologies that can detect gene variations such as single nucleotide polymorphisms (SNPs), for the first time scientists have the tools in hand to find the key immune genes and genetic networks that play roles in vaccine response.

Researchers report that one tiny variation in the sequence of a gene may cause some people to be more impaired by traumatic brain injury (TBI) than others with comparable wounds.

Equipped with faster, cheaper technologies for sequencing DNA and assessing variation in genomes on scales ranging from one to millions of bases, researchers are finding out how truly different we are from one another.

Using high - throughput sequencing of whole genomes will also be key in finding other kinds of genetic variation involved in autism, Grice explained.

Their achievement was aided by the progress in international cancer sequencing programs, which revealed characteristic sets of mutations and genetic variations in different cancers.

They also enlisted molecular methods beginning in the early 1990s, when arachnologists identified a half - dozen short, conserved spider DNA sequences that still had enough variation between species to derive relationships.

Genomics studies like those commonly conducted with HeLa cells play an instrumental role in revealing how variation in genome sequence and function can lead to disease.

Variations in N - CAM activity thus do not occur by changes in the amino acid sequence that alter the specificity of binding.

So geneticists have been focusing on the dog as a possible model for gene searches because this lack of sequence variation may help them circumvent a frequent problem with studies in humans.

Because the computer knows the filter pattern for each exposure, it can calculate the image from variations in the sequence of gray pixels captured by the camera.

All modern variation in these sequences traces back to Africa and shows relatively recent common ancestors.

Now back to those swallowtails: Grishin said their primary goal was really to devise a way to sequence genomes with high levels of genetic variation at a reasonable cost, but they were in for some surprises.

Genetic variation in antigenic, drug resistance, and pathogenesis determinants is abundant, consistent with an ancient origin of P. falciparum, whereas DNA variation at silent (synonymous) sites in coding sequences appears virtually absent, consistent with a recent origin of the parasite.

This study further investigated the impact of nicotine use / smoking status and variation in the mu opioid receptor gene (OPRM1), specifically, an A118G single nucleotide polymorphism (SNP, or DNA sequence variation), on the effects of naltrexone on a range of drinking outcomes.

Additional examination of the two genes in anoxeria - prone families gave the researchers a handle on which DNA sequence variations conferred the most risk.

If variation of the sequence of a specific gene is greatly reduced in modern versions, this is considered a sign that it was shaped by the selective pressures of domestication.