As Wroblewski, Parham, and co-authors explain in a PLOS Biology study published online today, they analyzed stool samples dating back 15 years and
sequenced immune system genes from 125 chimpanzees.
Not exact matches
Lo was encouraged by the variants because retroviruses are extremely mutable pathogens that change their
gene sequences again and again in response to
immune system efforts to kill them.
When they
sequenced the complete genomes of the Y. pestis DNA in those seven individuals, the team found that the bacterial genomes from the earliest samples lacked two
genes that helped Y. pestis evade the
immune systems of humans and fleas during the Black Death.
«In addition, many of the high - frequency
sequences span
genes involved in the
immune system, which is a frequent target of adaptive evolution.»
For example, when the researchers decoded the complete
sequence of one extrachromosomal circular phage from a disease - causing Staphylococcus, they identified a number of
genes that may help this strain evade a host's
immune system and that could readily spread to other Staphylococcus bacteria.
All seven were located in or near complement
genes (that's «complement» as in the innate
immune system complex), which had been implicated in AMD by
sequencing studies over the past couple of years.