Sentences with phrase «sequences of genes expressed»

This is the first study in human trials to identify genes driving acute peanut allergic reactions using a double - blind placebo - controlled approach with comprehensive sequencing of genes expressed before, during, and after they ingested peanut.

Not exact matches

Biologists now know that the genome sequence holds only a small part of the answer, and that key elements of development and disease are controlled by the epigenome — a set of chemical modifications, not encoded in DNA, that orchestrate how and when genes are expressed.

The policy — in the form of first Office Actions on a series of applications for patents on expressed sequence tags, ESTs — could greatly complicate basic gene therapy research by substantially allowing patents for small sequences of a gene that may later be used by the patent holder to corner ownership and uses of entire genes.

Epigenetic modifications do not affect the DNA sequence of genes, but change how the DNA is packaged and how genes are expressed.

But the benefits of this technology for discerning the circuits of the mind go much deeper, because the virus that carries the photoreceptor genes can also carry promoter sequences that express their payload only in neurons with the appropriate molecular address.

Molecular geneticists dream of having a similarly comprehensive view of networks that control genes: For example, they would like to identify rules explaining how a single DNA sequence can express different proteins, or varying amounts of protein, in different circumstances (see p. 80).

RNA sequencing of both single and clustered CTCs from breast cancer patients identified several genes expressed at elevated levels in CTC clusters, one of which — a protein called plakoglobin — also was overexpressed in the primary tumors of patients with reduced survival.

They then used next generation sequencing — a state - of - the - art method to rapidly measure gene expression — to sequence and quantify the thousands of genes that are expressed in hair cells, in comparison with other cells in the ear.

The BBSRC - funded ARK - Genomics facility — which is part of Edinburgh Genomics at the University of Edinburgh — provided a substantial body of sequence data, including information on which genes are expressed in a spectrum of 40 different tissues.

SEATTLE — Apparently ending several years of uncertainty, an official of the U.S. Patent and Trademark Office (PTO) revealed here today that the government intends to grant patents on expressed sequence tags (ESTs), human DNA sequences of up to a few hundred base pairs in length that can be used to identify and detect the expression of specific genes.

The team, headed by OIST's Prof. Alexander Mikheyev of the Ecology and Evolution Unit and Dr. Claire Morandin, post-doctoral scholar at the University of Helsinki, collected queens and workers and sequenced the transcriptome — the full range of messenger RNA molecules expressed by an organism — of 16 species of ants to create a co-expression network of 36 sets of genes, that represent groups of similarly expressed genes.

Single - cell RNA sequencing allows researchers to determine the precise nature of the total gene transcripts, or all of the genes that are actively expressed in a particular cell.

The human genome contains about 3 billion base pairs, but only about 2 percent of these base pairs represent protein - coding genes, meaning that whole - exome sequencing measures the genetic alterations focused on a small but very important fraction of the genome (as opposed to techniques of whole genome sequencing, which measures every nucleotide across the entire genome, regardless of whether these genes are expressed or silent).

The Yale - led study performed whole exome sequencing ¬ — a technique for sequencing all the expressed genes in a genome ¬ — on TNBC tumors to identify mutations in specific genes or pathways that may indicate response or resistance to the standard of care, which is anthracycline / taxane (ACT) chemotherapy.

By isolating strands of complementary DNA (cDNA) that fit together with mRNA, researchers can figure out what sequence was just translated into mRNA — that is, they can get a read on an expressed gene.

But because the vinclozolin - induced fertility changes occurred in almost every male rat descended from a treated mother rather than in a small percentage of offspring (as is seen in germ line mutations caused by radiation), Skinner suspects an epigenetic mechanism — a change that doesn't mutate the DNA sequence of an animal, but rather affects how genes are expressed.

Seeking to understand how the cone snail springs its slow - motion trap, the Utah researchers searched the gene sequences of all of the proteins expressed in the venom gland of Conus geographus.

Epigenetics is the study of changes to DNA packaging that influence which genes are expressed but don't affect the DNA sequence itself.

Then, if you want only certain types of cells to express the protein they encode, you must add a «promoter», i.e. a small DNA sequence which regulates expression, to this gene.

Expressed sequence tag analysis of genes expressed in the bay scallop, Argopecten iExpressed sequence tag analysis of genes expressed in the bay scallop, Argopecten iexpressed in the bay scallop, Argopecten irradians.

To assess the speed with which both humans and chimpanzees accumulated many small differences in gene sequences accurately, Wu and colleagues in Taiwan and Japan decided to sequence several thousand genes expressed in the brain of the macaque monkey and compare them with available genomic sequences from human, chimpanzee, and mice.

Although over 270,000 human expressed sequence tags (ESTs) were available in public databases as of October, 1995, it is still unclear how many genes have been identified by this methodology (Jordan, 1996).

Piroska Szabó of the Van Andel Research Institute in Grand Rapids, Michigan, was once excited to think she'd discovered a new gene that expressed only the maternal allele — until she realized that the RNA sequences she was looking at were from a gene that had been misannotated as a nuclear gene, explaining the maternal - only inheritance.

We found 1,098 genes in the sequence, of which 99 encode proteins expressed in testis and in various tumour types.

To find a solution to this, Marcel Martin at Bioinformatics Long - term Support (WABI) at SciLifeLab, in collaboration with the group of Gunilla Karlsson Hedestam at Karolinska Institutet, has developed a practical, computational technique, IgDiscover, that enables rapid production of individualized V gene databases following deep sequencing of expressed antibody repertoires.

has developed a practical, computational technique, IgDiscover, that enables rapid production of individualized V gene databases following deep sequencing of expressed antibody repertoires.

This permissive expression includes lineage - specific and tissue - specific genes, non-coding regions of the genome that are normally «silent,» and repetitive sequences in the genome, which comprise the majority of the mammalian genome but are also normally not expressed.

We are using a new technique, called single cell RNA sequencing, to isolate thousands of single neurons from human brain tissue, study all the genes that are expressed in each individual cell, and make cell - to - cell comparisons between normal, early stage and late stage AD.

Although the researchers found no change in the coding region of the gene, they did find that autistic children were much more likely to have inherited a shortened form of the genes promoter — the DNA sequence that serves as the on ramp for the cellular machinery that will express the gene.

By comparing the promoter sequences of expressed with non-expressed OR and VR genes and pseudogenes, it may now be possible to identify key genomic motifs that control receptor choice.

MicroRNAs are short sequences of genetic material that play a role in regulating how genes are expressed.

Specifically, we have generated clusters of transcripts that behave the same way under the entire spectrum of the sixty - seven experimental conditions; we have assembled genes in groups according to their time of expression during successive days of ES cell differentiation; we have included expression profiles of specific gene classes such as transcription regulatory factors and Expressed Sequence Tags; transcripts have been arranged in «Expression Waves» and juxtaposed to genes with opposite or complementary expression patterns; we have designed search engines to display the expression profile of any transcript during ES cell differentiation; gene expression data have been organized in animated graphs of KEGG signaling and metabolic pathways; and finally, we have incorporated advanced functional annotations for individual genes or gene clusters of interest and links to microarray and genomic resources.

As part of an ongoing functional genomic screening approach, we have been using microarray analysis and next generation sequencing to identify mouse genes that are specifically expressed in meiosis, and are likely involved in aspects of chromosome biology that are required for meiotic ploidy reduction.