Cold Spring Harbor Laboratory scientist Robert Martienssen was instrumental in organizing the international
sequencing effort at its outset in 1996, and played a major role in interpreting the chromosome 4 results.
«Their performance has been remarkable,» says Richard Gibbs, who heads the public
sequencing effort at Baylor College of Medicine in Houston.
Not exact matches
It will focus its initial clinical
sequencing efforts on cancer, teaming up with the Moores Cancer Center
at the University of California, San Diego to
sequence the genomes of every patient who is treated there, as well as perform a full genome
sequence on their tumors.
The trust now plans to increase its spending from $ 160 million to $ 325 million over 7 years
at the Sanger Centre near Cambridge — Britain's main gene
sequencing laboratory — for more painstaking
efforts to
sequence a third of the human genome by 2005.
«In addition to funding rice
sequencing, the [Thai] government is about to launch an
effort that will move on to functional genomics,» says Apichart Vanavichit, a molecular biologist
at Thailand's National Center for Genetic Engineering and Biotechnology in Nakorn Pathom, which is helping to
sequence chromosome 9.
Rapid advances in genome
sequencing have provided promising new techniques to help researchers conserve endangered species, but
efforts to resurrect extinct animals raise complex legal, ethical and environmental questions, experts said
at a 4 November event
at AAAS.
As scientists began to
sequence human genes in the 1990s, sorting out the cellular locations of each gene's proteins became a priority, says Mathias Uhlén, a microbiologist
at the Royal Institute of Technology in Stockholm, Sweden, and director of the Protein Atlas
effort.
To demonstrate the utility of the gorilla Y chromosome
sequence they generated, the researchers designed genetic markers that can be used to differentiate the genetic relatedness among male gorillas and thus to aid in conservation genetics
efforts targeted
at preserving this endangered species.
Figueroa co-led the
sequencing effort for the oat crown rust fungus P. coronata f. sp. avenae along with Shahryar Kianian, research leader
at the USDA - ARS Cereal Disease Laboratory and adjunct professor
at the University of Minnesota.
At Weill Cornell, Imielinski is participating in the precision oncology
effort, which will
sequence tumor DNA to match patients to particular therapies.
Her lab selected and grew the algae for
sequencing in a collaborative
effort with CIFAR Fellow Adrián Reyes - Prieto, who she first met
at the Institute's program meetings.
Warinner began her graduate studies
at Harvard in 2004, just after the
sequencing of the human genome was completed and by the time she left in 2010,
efforts to survey the human microbiome were in full swing.
If such
efforts succeed, says Robert Waterston, a geneticist who heads the genome
sequencing center
at Washington University in St. Louis, Missouri, the technique «could be the start of something impressive.»
In an
effort to better understand and help combat the ants, a group of researchers led by Neil Tsutsui
at the University of California, Berkeley,
sequenced the genome of L. humile.
Richard Gibbs and colleagues
at the genome center
at Baylor College of Medicine in Houston, Texas, will lead the
effort, and a group
at Celera Genomics in Rockville, Maryland, will add brute - force
sequencing power.
In 2012, as part of
efforts to better understand the causes of melanoma, researchers
at the Broad Institute, the Dana - Farber Cancer Institute and a number of other institutes reported the results of whole genome
sequencing of 25 human metastatic melanomas (Berger et al., 2012).
Paul Lasko and Beat Suter,
at McGill University, are extending the work of the Wright laboratory (Stathakis et al., 1995) in the genetic and molecular analysis of a similarly sized genomic segment comprising polytene regions 37 and 38 and this will be an early target for the BDGP
sequencing efforts.
«What's important about the maize project,» says W. Richard McCombie, Ph.D., CSHL Professor, co-principal investigator on the maize genome project, and a pioneer in genome
sequencing efforts, «is that it provides a reference DNA
sequence for the most important agricultural crop in the U.S., making it much easier for people to look
at the many variants of different strains or «accessions» of maize.»
If budget permits,
sequencing genomes with both HiSeq2000 and Complete Genomics allows the combination of HiSeq2000's strength in sensitivity of SNV calling even
at low coverage with Complete Genomics» strength in uniformly covering the entire genome, offering an interesting potential to boost the strengths of both platforms with considerably low
efforts.
The
Sequencing and ncRNA Program (ncRNA core), led by Chang - Gong Liu, Ph.D., is a shared resource established in 2009 to support ncRNA cancer research
efforts at MD Anderson Cancer Center and Institutions under the UT system.
A 2006 study by Martin Gibala, a physiologist
at McMaster University in Ontario, showed that a 3 - minute
sequence on a stationary bicycle — 30 seconds of maximal
effort pedaling, followed by a brief rest, repeated five or six times — led to the same health benefits as 90 to 120 minutes of steady - state cycling.
The film's pervasively underwhelming atmosphere is perpetuated by the inclusion of several eye - rollingly misguided
sequences (eg Santa and a few elves are trapped inside a child's bedroom), with the resulting lack of momentum ensuring that the episodic midsection, which revolves primarily around Arthur's ongoing
efforts at finding said little girl's house, fares especially poorly and is, for the most part, nothing short of interminable.
The domestic - drama atmosphere keeps things interesting for a little while, although there inevitably reaches a point
at which stagnancy sets in - with Angelo's
efforts at compensating for the stale vibe resulting in a number of thoroughly questionable stand - alone
sequences (including an absolutely unwatchable stretch set
at a friend's home birth).
Highlighted by yet another excellent audio commentary by writer / director Craig Brewer, the single - disc
effort also includes a making - of featurette («Conflicted»), a behind - the - scenes look
at the filming of the «Black Snake Moan» musical
sequence, and another on the film's musical influences («Rooted in the Blues»).
In addition to the imaginative fantasy
sequences (which impressively entail so much time and
effort for so brief a joke), the exchange of dialogue often moves
at a rapid clip and the show is slickly - edited with a mix of long takes on a moving camera and quick cuts.
Despite this freewheeling narrative style, the piecing together of which has earned editor Tatiana S Riegel an Oscar nomination, the ice - skating
sequences are fabulous, with Gillespie and cinematographer Nicolas Karakatsanis joining forces brilliantly to show the
effort, speed and skill that goes into figure skating
at the highest level.
There's little doubt, however, that Reiner's decidedly deliberate sensibilities, coupled with the episodic bent of Raynold Gideon and Bruce A. Evans» script, ensures that the movie's first half isn't quite as electrifying as one might've hoped, as it's clear that certain
sequences ultimately fare a whole lot better than others - with the boys»
efforts at safely crossing a railroad bridge certainly standing as a highlight within the film's opening hour.
Mr. Mom is, generally speaking,
at its best when focused on Jack's dogged
efforts at coping with his new situation (eg a hilarious
sequence in which everything that could go wrong does), as the movie doesn't fare quite as well when it leaves the confines of the Butler household (eg an eye - rolling silly interlude detailing Jack's participation in an obstacle course).
It's fairly clear, however, that the movie does suffer from a midsection that occasionally feels just a little too uneventful, as Hitchcock offers up several
sequences that come off as aggressively prolonged or entirely unnecessary (eg Bates»
efforts at cleaning up a dead body, which seem to unfold in real time, perfectly exemplifies the former).
Delaware (where my daughter just moved) is right, Secretary DeVos should review this guidance letter, and until the federal government gets its act together on secondary education (which it appears may never happen), families should opt out of state schools subject to federal dictates, opting in, instead, to learning institutions that embed preparation for exams
at a pre-university level that can lead to placement advanced in future course
sequences: these advanced level subjects should be embedded within the balanced curriculum that an international baccalaureate education represents, in contrast to the narrow extension of elementary school that DC bureaucrats remain focused on, as if time had not run out on the Obama administration and its failed
efforts to improve the lives of American youth, now mired in debt that it encouraged in pursuit of a «North Star» goal that led the United States astray.
For example, in the mid-1980s, North Carolina created the Teaching Fellows Program, an
effort to attract bright young college students into teaching, give them rigorous preparation, and keep them in the profession —
at one point, the initiative even funded scholarships for 11,000 new recruits to enroll in revamped teacher education
sequences at a number of the state's universities.
On his statement that he initially reacted in horror to the
sequence of failed
efforts at stopping the oil by «thinking those morons don't know what they're doing»: