In the meantime, we are in the midst of large - scale
sequencing efforts for the Centers for Complex Disease Genomics (CCDG), Alzheimers Disease Sequencing Project (ADSP), and Gabriella Miller Kids First (GMKF) initiatives.
This pattern is consistent with the results of
the sequencing efforts for rice centromeres 4 and 8 as well as other rice [4] and maize [11] BACs that contain centromeric satellite sequence.
Figueroa co-led
the sequencing effort for the oat crown rust fungus P. coronata f. sp. avenae along with Shahryar Kianian, research leader at the USDA - ARS Cereal Disease Laboratory and adjunct professor at the University of Minnesota.
Not exact matches
Venter, who is one of the first people to
sequence the human genome, co-founded the company in
effort to discover early genetic markers
for a variety of disorders.
A consortium of peanut growers, peanut shellers, brokers and food manufacturing groups provided $ 6 million in funding
for the genome
sequencing effort through The Peanut Foundation.
A recently completed genome
sequence of the new virus has sped up
efforts to come up with a diagnostic test to screen
for it
The trust now plans to increase its spending from $ 160 million to $ 325 million over 7 years at the Sanger Centre near Cambridge — Britain's main gene
sequencing laboratory —
for more painstaking
efforts to
sequence a third of the human genome by 2005.
Sequencing ancient DNA is expensive, so it can be hard
for new labs to enter the field, but
efforts are underway to develop methods to bring down the cost and make the field more accessible to newcomers.
The 15 AACR scientists, who were already in Washington, D.C., to meet with the U.S. Food and Drug Administration on genetic testing
for cancer patients, tossed around ideas including expanding NCI's tumor genome -
sequencing efforts and getting the government to cover the costs of genomic tumor profiling.
The
sequencing of the human genome is gearing up all those
efforts, and with each novel model organism
for which the
sequence has been determined, the power of comparative analysis increases.
«In addition to funding rice
sequencing, the [Thai] government is about to launch an
effort that will move on to functional genomics,» says Apichart Vanavichit, a molecular biologist at Thailand's National Center
for Genetic Engineering and Biotechnology in Nakorn Pathom, which is helping to
sequence chromosome 9.
Andre Rosenthal, who coordinates Germany's planned genomic
sequencing effort, left the meeting hopeful that the policy will be reversed
for these data.
When it is complete in 2008, EarthScope's web of instruments will provide public data
for geoscience, not unlike the way the human genome
sequencing effort has
for biology.
The project also serves as a model
for other countries»
efforts to
sequence their people's DNA
for research on personalized medical care, says study leader Kári Stefánsson, deCODE's CEO.
The discovery, the product of a multiyear
effort to provide a high - quality full genome map of the oil palm plant and to scour the
sequence for genes of importance to both science and industry, has major implications
for agriculture and the environment.
Her lab selected and grew the algae
for sequencing in a collaborative
effort with CIFAR Fellow Adrián Reyes - Prieto, who she first met at the Institute's program meetings.
The convergence of several factors explains the trend: cheaper genetic
sequencing technologies, the discovery of new oncogenes (genes that can cause a normal cell to become cancerous), a new generation of computers and bioinformatics that can analyze vast amounts of data, and a multibillion - dollar
effort by researchers inside and outside the pharma industry to develop targeted drugs and companion diagnostics
for cancer.
One well - accepted
effort compares the nucleic acid
sequences that code
for ribosomal RNA and a few proteins in many different organisms.
PARIS — Scientists have agreed to collaborate on an eagerly awaited
effort to
sequence the genome of the mosquito Anopheles gambiae, the main vector
for the malaria parasite in sub-Saharan Africa.
Fifteen teams analyzed nearly 500 patients» tumors
for genetic aberrations and
sequenced the protein - coding DNA of 316 samples — by far the largest cancer
sequencing effort to date.
Efforts to identify host range and cell tropism of TMAdV, as well as the specific
sequence changes responsible
for adaptation to growth in cell culture, are currently underway.
Many smaller proposals went unfunded, including one that I helped put together: a computational
effort to mine existing
sequence trace archives
for reads harboring structural variants.
She has contributed to widely varying fields — such as viral
sequencing, information theory, rural disease surveillance, and education
efforts in West Africa — to create comprehensive approaches
for detecting, containing, and treating deadly infectious diseases.
Sparked from the
efforts of the T2D - GENES Consortium (Type 2 Diabetes Genetic Exploration by Next - generation
sequencing in multi-Ethnic Samples; T2D - GENES) to aggregate and share results from large - scale T2D
sequence and genotype datasets, the prototype T2D KP was built with seed funding from the NIDDK via the T2D - GENES Consortium and the Slim Initiative
for Genomic Medicine in the Americas
for T2D (SIGMA T2D).
The CNAG - CRG makes
efforts to promote the utilization of next - generation
sequencing technology
for rare disease applications.
Venter is known
for leading private - sector
efforts to
sequence the human genome
for the first time, in addition to booting up the first «synthetic life» in 2010.
For the past two years, we've been part of the Alzheimer's Disease
Sequencing Project (ADSP), a $ 50 million
effort to identify new genomic variants contributing to late - onset Alzheimer's Disease.
Paul Lasko and Beat Suter, at McGill University, are extending the work of the Wright laboratory (Stathakis et al., 1995) in the genetic and molecular analysis of a similarly sized genomic segment comprising polytene regions 37 and 38 and this will be an early target
for the BDGP
sequencing efforts.
The reasons
for this are complex, and not the focus of this post, but I think we can all agree that it's vital to seek out and include samples from diverse ancestries as large - scale
sequencing efforts move forward.
Most of that is by design: the 1,000 Genomes Project generated and made available
sequence data
for more than 1,000 individuals in an
effort to further characterize human genetic variation.
Mark S. Guyer, Ph.D., currently director of NHGRI's Division of Extramural Research, becomes only the third deputy director of the institute, which was originally founded in 1988 as an office to lead NIH's portion of the
effort to
sequence the human genome
for the first time.
«What's important about the maize project,» says W. Richard McCombie, Ph.D., CSHL Professor, co-principal investigator on the maize genome project, and a pioneer in genome
sequencing efforts, «is that it provides a reference DNA
sequence for the most important agricultural crop in the U.S., making it much easier
for people to look at the many variants of different strains or «accessions» of maize.»
Now, researchers involved in an international
effort to
sequence the entire genome of Arabidopsis have obtained -
for the first time - the complete DNA
sequence of chromosomes from a plant species.
Efforts to combat tuberculosis have intensified recently, and an essential tool
for researchers is the genome
sequence of M. tuberculosis.
Large - scale
sequencing efforts like the 1,000 Genomes Project and The Cancer Genome Atlas now consider BAM the standard format
for data exchange.
Then we were off and running
for CCDG and another large - scale
sequencing effort funded under the Gabriella Miller Kids First (GMKF) program.
An international
effort to analyze the entire database of Ebola virus genomes from the 2013 — 2016 West African epidemic reveals insights into factors that sped or slowed the rampage and calls
for using real - time
sequencing and data - sharing to contain future viral disease outbreaks.
In it, the authors review bioinformatics approaches
for evaluating single - base substitutions in both coding and noncoding regions, with an emphasis on large cancer resequencing
efforts including the Tumor
Sequencing Project, the Cancer Genome Atlas (TCGA), and the AML1 cancer genome.
Here, we combined the
efforts of population geneticists and genetic genealogists to use the potential of full Y - chromosome
sequencing for reconstructing haplogroup Q3 phylogeography and suggest possible linkages to events in population history.
Topics that will be explored include: • Cellular and developmental origins of pediatric cancer • Key findings of pan-cancer analysis
efforts • Computational pipelines to analyze large - scale
sequencing data • Opportunities
for leveraging existing cancer genomics datasets • Strategies
for integrative analysis of germline and somatic variants • Correlation of germline / somatic variation to clinical features such as tumor subtype.
Next - generation genome
sequence data are essential
for these
efforts.
Predicted role
for the archease protein family based on structural and
sequence analysis of TM1083 and MTH1598, two proteins structurally characterized through structural genomics
efforts.
Pull your
efforts for losing the extra kilos by following this
sequence along with a suitable diet chart.
The film's pervasively underwhelming atmosphere is perpetuated by the inclusion of several eye - rollingly misguided
sequences (eg Santa and a few elves are trapped inside a child's bedroom), with the resulting lack of momentum ensuring that the episodic midsection, which revolves primarily around Arthur's ongoing
efforts at finding said little girl's house, fares especially poorly and is,
for the most part, nothing short of interminable.
xtremely bizarre and only somewhat entertaining, Frank Miller's «The Spirit» focuses all of its
efforts on flashy visuals and cartoonish humor — forgetting to leave room
for action
sequences and a story.
The domestic - drama atmosphere keeps things interesting
for a little while, although there inevitably reaches a point at which stagnancy sets in - with Angelo's
efforts at compensating
for the stale vibe resulting in a number of thoroughly questionable stand - alone
sequences (including an absolutely unwatchable stretch set at a friend's home birth).
As with any MacFarlane
effort, where he once again teams with co-writers Alec Sulkin and Wellesley Wild, pop - culture references is the first port of call
for joke - central, and the sequel is again over-loaded with them: the Planes, Trains and Automobiles and The Breakfast Club
sequences are a hoot, but the Comic Con finale feels flat, more creative auto - pilot than uncharted waters.
In addition to the imaginative fantasy
sequences (which impressively entail so much time and
effort for so brief a joke), the exchange of dialogue often moves at a rapid clip and the show is slickly - edited with a mix of long takes on a moving camera and quick cuts.
DIE ANOTHER DAY Nobody is likely to be bored by the latest James Bond installment, but that's about the best that can be said
for this middling
effort that, while intermittently captivating, has surprisingly witless dialogue and some action
sequences that are silly without being charming.
While his name is not appearing on too many of the advertisements, opting instead
for citing his previous directorial
efforts, and despite all of his troubles, Gibson has proven himself an incredible filmmaker who is able to deliver rousing set pieces and indelible
sequences that stay with audiences long after the credits.