It will focus its initial clinical
sequencing efforts on cancer, teaming up with the Moores Cancer Center at the University of California, San Diego to sequence the genomes of every patient who is treated there, as well as perform a full genome sequence on their tumors.
A massive genetic
sequencing effort on seed - bank holdings to document what exists in the collections, to strategically target experiments to evaluate what traits a plant has (called phenotyping) and to begin to predict plant performance.
Not exact matches
But the other elements of community organizing would come together again and again: the foot - slogging, one -
on - one recruitment
effort to form an organization of organizations, the struggle to get past ethnic differences, the taking of the public stage, the
sequence of conflict - organization - power as the route to negotiation, and the critical relationship to other social movements — which became a guarded relation to the civil rights movement.
The U.S. National Science Foundation — funded
effort will tap extensive museum collections as much as possible, instead of freshly caught bird samples, and will
sequence about 5000 short pieces of the DNA, focusing
on regions that are very highly conserved among all birds.
The 15 AACR scientists, who were already in Washington, D.C., to meet with the U.S. Food and Drug Administration
on genetic testing for cancer patients, tossed around ideas including expanding NCI's tumor genome -
sequencing efforts and getting the government to cover the costs of genomic tumor profiling.
«In addition to funding rice
sequencing, the [Thai] government is about to launch an
effort that will move
on to functional genomics,» says Apichart Vanavichit, a molecular biologist at Thailand's National Center for Genetic Engineering and Biotechnology in Nakorn Pathom, which is helping to
sequence chromosome 9.
As a part of these
efforts, researchers from CAAS and BGI re-sequenced 115 cucumber lines sampled from 3,342 accessions worldwide, and also conducted de novo
sequencing on a wild cucumber.
National Human Genome Research Institute Director Francis Collins, one of the leaders behind the public
effort to
sequence the genome, can now move
on to other projects.
Large - scale genome
sequencing efforts, like the Human Microbiome Project, have focused
on the community of microorganisms that live in the human gut.
In this research
effort, scientists conducted DNA
sequencing on more than 500 adults and children with DCM and more than 1,100 healthy controls from several ethnically distinct cohorts to learn about the genetic profile of the disease.
The project also serves as a model for other countries»
efforts to
sequence their people's DNA for research
on personalized medical care, says study leader Kári Stefánsson, deCODE's CEO.
By better understanding the limitations of genome - wide
sequencing, Vogelstein notes, researchers and policymakers might be better able to direct funding and
efforts to areas, such as Alzheimer's disease, where a person's genetic profile might have a very real effect
on their likelihood of getting the disease.
One way to conceptualize these systems is to think of the processes involved in driving a car: the novice needs to rely
on controlled processing, requiring focused concentration
on a
sequence of operations that require mental
effort and are easily disrupted by any distractions.
PARIS — Scientists have agreed to collaborate
on an eagerly awaited
effort to
sequence the genome of the mosquito Anopheles gambiae, the main vector for the malaria parasite in sub-Saharan Africa.
With the
effort to
sequence the entire human genome speeding toward completion, some researchers are now focusing their energy
on developing the next generation of tools that can be used to extract...
We expanded
on our genome
sequencing efforts to include
efforts in whole genome gene expression analysis and functional analysis of genome variation.
Building
on the foundation laid by the Human Genome Project, Dr. Collins is now leading NHGRI's
effort to ensure that this new trove of
sequence data is translated into powerful tools and thoughtful strategies to advance biological knowledge and improve human health.
Other
efforts include array - based
sequencing - by - hybridization with Callida Genomics, and simultaneous typing of SNPs
on chromosomal regions undergoing LOH using customized Affymetrix tag - arrays.
Complex
sequence and «HapMap» shed light
on maize's «wonderful diversity» could help in future
efforts to adapt the plant to a warming climate
«What's important about the maize project,» says W. Richard McCombie, Ph.D., CSHL Professor, co-principal investigator
on the maize genome project, and a pioneer in genome
sequencing efforts, «is that it provides a reference DNA
sequence for the most important agricultural crop in the U.S., making it much easier for people to look at the many variants of different strains or «accessions» of maize.»
In it, the authors review bioinformatics approaches for evaluating single - base substitutions in both coding and noncoding regions, with an emphasis
on large cancer resequencing
efforts including the Tumor
Sequencing Project, the Cancer Genome Atlas (TCGA), and the AML1 cancer genome.
Predicted role for the archease protein family based
on structural and
sequence analysis of TM1083 and MTH1598, two proteins structurally characterized through structural genomics
efforts.
Of course with enough time, money and
effort most DNA
sequences can eventually be built; de novo designed mammalian genome - scale synthesis however will require a drop in cost by orders of magnitude together with technology improvements to enable DNA synthesis without restrictions
on sequence composition.
A 2006 study by Martin Gibala, a physiologist at McMaster University in Ontario, showed that a 3 - minute
sequence on a stationary bicycle — 30 seconds of maximal
effort pedaling, followed by a brief rest, repeated five or six times — led to the same health benefits as 90 to 120 minutes of steady - state cycling.
After all, you want to focus most of your
efforts on the types of exercises,
sequencing, and combinations that stimulate the biggest increases in testosterone and growth hormone response.
xtremely bizarre and only somewhat entertaining, Frank Miller's «The Spirit» focuses all of its
efforts on flashy visuals and cartoonish humor — forgetting to leave room for action
sequences and a story.
Director Ericson Core («Invincible») and writer Kurt Wimmer (whose previous remake duties include «Total Recall» and «The Thomas Crown Affair») clearly want to up the ante
on the action, but they make almost no
effort to incorporate these stirring
sequences into the rest of the movie.
Highlighted by yet another excellent audio commentary by writer / director Craig Brewer, the single - disc
effort also includes a making - of featurette («Conflicted»), a behind - the - scenes look at the filming of the «Black Snake Moan» musical
sequence, and another
on the film's musical influences («Rooted in the Blues»).
In addition to the imaginative fantasy
sequences (which impressively entail so much time and
effort for so brief a joke), the exchange of dialogue often moves at a rapid clip and the show is slickly - edited with a mix of long takes
on a moving camera and quick cuts.
The storm
sequences and rescue
efforts, most of which were shot
on a soundstage and enhanced by computer graphics, go
on too long.
While his name is not appearing
on too many of the advertisements, opting instead for citing his previous directorial
efforts, and despite all of his troubles, Gibson has proven himself an incredible filmmaker who is able to deliver rousing set pieces and indelible
sequences that stay with audiences long after the credits.
There were flashes of quality in his two
efforts after the Bruce Willis horror - drama, Signs and Unbreakable, though both suffered from
sequences that bordered
on the ridiculous.
The truly spectacular action
sequences never falter, more seamlessly blending live - action performance and stunt work to CGI marvels: a rampaging battle staged
on the side of a building and a runaway train
sequence easily trounce the
efforts of the first film, and Raimi's effects team (again supervised by John Dykstra) also subtly improves upon the hero's web - slinging transit high above the city streets.
Mr. Mom is, generally speaking, at its best when focused
on Jack's dogged
efforts at coping with his new situation (eg a hilarious
sequence in which everything that could go wrong does), as the movie doesn't fare quite as well when it leaves the confines of the Butler household (eg an eye - rolling silly interlude detailing Jack's participation in an obstacle course).
A respectable action
effort that makes up for its lack of depth with tight pacing and some tense, brutal action
sequences that actually do manage to deliver
on visceral impact.
The city that is the focus of the plotter's
efforts is rarely seen
on screen however, with interiors far more prominent and prolonged
sequences in the Berghof and Wolf's Lair compounds.
Delaware (where my daughter just moved) is right, Secretary DeVos should review this guidance letter, and until the federal government gets its act together
on secondary education (which it appears may never happen), families should opt out of state schools subject to federal dictates, opting in, instead, to learning institutions that embed preparation for exams at a pre-university level that can lead to placement advanced in future course
sequences: these advanced level subjects should be embedded within the balanced curriculum that an international baccalaureate education represents, in contrast to the narrow extension of elementary school that DC bureaucrats remain focused
on, as if time had not run out
on the Obama administration and its failed
efforts to improve the lives of American youth, now mired in debt that it encouraged in pursuit of a «North Star» goal that led the United States astray.
All of this work is based
on our successful published
efforts to both build tools and analyze
sequence analysis from the canine genome.
Finally making your move brings an immense sense of satisfaction; it wasn't the game guiding you through some scripted
sequence where failure is nigh
on impossible, it was you carefully plotting an escape, gathering the tools needed, figuring out how to hide contraband and timing your every
effort.
I posted
on this
effort on my Tumblr page this morning, but now have reached Hachiya Kazuhiko, the Japanese artist) whose Twitter stream explaining the nuclear accident to his family started the
sequence of events that led to the animation.
On his statement that he initially reacted in horror to the
sequence of failed
efforts at stopping the oil by «thinking those morons don't know what they're doing»:
«New Zealand has a number of key
efforts to improve our understanding
on the involved
sequence of events, the thresholds, and processes — for example:
• Demonstrated expertise in scheduling appointments and treatments in accordance to medical conditions and priority
sequences • Proficient in assembling patient care charts and preparing medical records forms required for admissions, referrals and dismissals • Hands -
on experience in maintaining unit files, transporting supplies and specimens and coordinating
efforts with medical agencies to schedule patient services