Sentences with phrase «sequencing of the human genome as»

The man responsible for one of the original sequences of the human genome as well as the team that brought you the first living cell running on human - made DNA now hopes to harness algae to make everything humanity needs.

«The quality of this sequence is comparable to the first sequencing of the human genome as published 15 years ago, which revolutionized biomedical research at that time,» enthuses Matthias Platzer — research group leader at the FLI and involved in both the human and fish genome sequencing progressions.

Not exact matches

Aug. 30, 2012: The genome of a recently discovered branch of extinct humans known as the Denisovans that once interbred with us has been sequenced

The entire genome of the tiny nematode (Caenorhabditis elegans) also has been sequenced as a ta - ngen = tial study to the human genome project.

Aug. 30, 2012: The genome of a recently discovered branch of extinct humans known as the Denisovans that once interbred with us has been sequenced Anyone find fossils of Adam and Eve yet?

In February, researchers published the first ancient American human genome, sequencing DNA from the remains of a boy known as Anzick - 1, who was buried about 12,600 years ago in what is now western Montana.

The estimate of the number of human genes has been repeatedly revised down from initial predictions of 100,000 or more as genome sequence quality and gene finding methods have improved, and could continue to drop further.

Their work has made it increasingly clear that for all the popular attention devoted to genome - sequencing projects, the epigenome is just as critical as DNA to the healthy development of organisms, humans included.

«We explored the opportunity of using sperm RNA elements as a predictor of human health, with applications at the fertility clinic that would go hand - in - hand with the new neonatal intensive care unit genome sequencing to better health outcomes,» said Dr. Krawetz, associate director of the C.S. Mott Center for Human Growth and Develophuman health, with applications at the fertility clinic that would go hand - in - hand with the new neonatal intensive care unit genome sequencing to better health outcomes,» said Dr. Krawetz, associate director of the C.S. Mott Center for Human Growth and DevelopHuman Growth and Development.

By comparing it with that of modern humans, chimpanzees and bonobos, plus Neanderthals and Denisovans, Meyer estimated its age at 400,000 years, twice as old as our own species and far older than any hominin genome previously sequenced (Nature, DOI: 10.1038 / nature12788).

As the cost of sequencing the human genome has plummeted in recent years, many medical researchers have touted the potential of personalized medicine — exotic therapies and synthetic drugs that are tailored to our individual genetic makeup.

Boyd et al. sequenced the genomes of symbiotic bacteria from human lice as well as the closely related chimpanzee, gorilla and red colobus monkey lice.

Work is expected to begin as soon as participants at genome centers in the United States and abroad agree on some ground rules for the project, perhaps the most unwieldy collaboration since the sequencing of the human genome.

As when he worked on the human genome, Venter is relying on a radical technique called shotgun sequencing: He chops up vast amounts of DNA into tiny pieces and then uses sophisticated computer analyzers to piece them back together into intelligible genes and chromosomes.

The sequencing of the first genome involving a cockroach species may one day serve as a model system comparable to how research on mice can apply to humans.

Just as the Human Genome Initiative in the 1990s sequenced human DNA for the subsequent identification and analysis of genes, so too will the Materials Genome Initiative sequence materials for identifying new properties for a variety of applicatHuman Genome Initiative in the 1990s sequenced human DNA for the subsequent identification and analysis of genes, so too will the Materials Genome Initiative sequence materials for identifying new properties for a variety of applicathuman DNA for the subsequent identification and analysis of genes, so too will the Materials Genome Initiative sequence materials for identifying new properties for a variety of applications.

As scientists race to decode genomes — not just of humans but of bacteria, yeast, chimps, dogs, whales and plants — the number of DNA sequences available for analysis has grown 40,000-fold in the past 20 years, providing unprecedented insight into billions of years of species evolution.

This was a daunting task, as the barley genome is almost twice the size of the human genome and 80 percent of it is composed of highly repetitive sequences, which can not be assigned accurately to specific positions in the genome without considerable extra effort.

With the completion of the first phase of the Human Genome Project in 2000, and the advent of sequencing technologies that can detect gene variations such as single nucleotide polymorphisms (SNPs), for the first time scientists have the tools in hand to find the key immune genes and genetic networks that play roles in vaccine response.

The advent of large - scale genome sequencing has helped scientists identify DNA bacteriophages in the human gut, skin and blood as well as in the environment, but few researchers have looked for RNA bacteriophages in those samples.

The nematode project is also seen as an ideal way of perfecting the mapping and sequencing strategies researchers will need for their final assault on the human genome, which is some 30 times bigger.

The genome shares about 60 % of its genes with the other invertebrates completely sequenced, such as the nematode and fruit fly, whereas about 5 % match sequences found only — up to now, at least — in the human, mouse, and puffer fish genomes.

Even as the genome sequencing heavyweights scramble to finish a rough draft of the human genome, they have taken on equally monumental task: churning out a rough draft of the mouse genome by 2003.

The study, conducted in both human and mouse cells, shows that cancer genomes lose copies of repetitive sequences known as ribosomal DNA.

Venter: This prize started out as a half million dollar prize out of the Venter Institute, in part after I sequenced the first version of the human genome.

The high degree of similarity between the mouse and human genomes is demonstrated through analysis of the sequence of mouse chromosome 16 (Mmu 16), which was obtained as part of a whole - genome shotgun assembly of the mouse genome.

The human genome contains about 3 billion base pairs, but only about 2 percent of these base pairs represent protein - coding genes, meaning that whole - exome sequencing measures the genetic alterations focused on a small but very important fraction of the genome (as opposed to techniques of whole genome sequencing, which measures every nucleotide across the entire genome, regardless of whether these genes are expressed or silent).

He added: «The sequencing of genomes from this key region will have a major impact on the fields of palaeogeneomics and human evolution in Eurasia, as it bridges a major geographic gap in our knowledge.»

«As the Baylor - Johns Hopkins Center for Mendelian Genomics enters year three of our four year grant, we have found new learning opportunities with each phenotype,» said Shalini Jhangiani, senior project manager in the Human Genome Sequencing Center and a co-author on the study.

As director of Technology Development, she has helped create methods and automation pipelines for sequencing the human genome.

He says HGS was getting «diminishing returns» from its investment in TIGR since Venter had steered his outfit into sequencing organisms of little medical importance, and into human genome sequencing, also of limited value for a company like HGS that is interested in genes as drug targets (not untranslated DNA that makes up most of the genome).

Western Pygmies I love population genetics for its ability to peer back into human history through the medium of DNA's ATCGs.One of the stars of this discipline is Sarah Tishkoff, a standout in African genetics, someone who will readily haul a centrifuge into the bush in Cameroon.Tishkoff of the University of Pennsylvania is lead author on a paper published online July 26 in Cell that details whole - genome sequencing of five individuals each from three extant hunter - gatherer groups — the Pygmies of Cameroon as well as the Hadza and the Sandawe of Tanzania.

Using a specific work flow, they assessed both the coding and noncoding regions of the human genome, including the evaluation of highly polymorphic SNPs, structural and copy number variations, as well as 69 control genomes sequenced by the same procedures.

The study broke new ground in other areas as well, yielding the first ancient whole genomes of East Asian ancestry and the highest coverage ancient human genome from Asia (7x coverage) sequenced to date.

«The availability of the human genome sequence, as well as other genomic resources produced by our sequencing centers, has transformed biomedical research everywhere,» said NHGRI's Associate Director of Extramural Research Jane Peterson, Ph.D., who is also a program director for NHGRI's Large - Scale Sequencing Researcsequencing centers, has transformed biomedical research everywhere,» said NHGRI's Associate Director of Extramural Research Jane Peterson, Ph.D., who is also a program director for NHGRI's Large - Scale Sequencing ResearcSequencing Research Network.

In 2012, as part of efforts to better understand the causes of melanoma, researchers at the Broad Institute, the Dana - Farber Cancer Institute and a number of other institutes reported the results of whole genome sequencing of 25 human metastatic melanomas (Berger et al., 2012).

The sequencing centers also will focus increased attention on sequencing the genomes of organisms, such as bacteria, fungi, parasites and insects, which cause or transmit human diseases.

The objectives of this initial work are to sequence the genomes of 200 microbes that have been isolated from the human body as part of the 1,000 microbial genomes collection.

Reykjavik, ICELAND, 25 September 2011 — Scientists at deCODE Genetics and academic collaborators from Iceland, The Netherlands, Spain, Denmark, Germany, Sweden, the USA, the UK and Romania today report the discovery of a variant in the sequence of the human genome associated with risk of developing basal cell carcinoma of the skin (BCC), as well as prostate cancer and glioma, the most serious form of brain cancer.

I will review recent advances in the use of nanopore sequencing for clinical microbiology and human genetics, including our collaborations on viral and bacterial diagnostic sequencing, real - time surveillance, direct RNA and human whole - genome sequencing, and discuss the opportunities and barriers around moving to sequencing as a routine test in the clinic.

The researchers, an international group known as the Mouse Genome Sequencing Consortium, report that approximately 99 percent of mouse genes have counterparts in humans.

Major focus areas include human genome interpretation and genetic dissection of novel rare diseases, predictive genomic signatures of response to therapy — especially cancer therapy, and novel sequencing - based assays as biomarkers of disease.

Genome sequencing, not of humans but of model organisms such as yeast and fruitfly, was in full swing by the late 1990s.

Biological Annotation of the Genomic Sequence A key use of the sequence information from the canonical model organisms, such as Drosophila, will be to help interpret the sequence of the humanSequence A key use of the sequence information from the canonical model organisms, such as Drosophila, will be to help interpret the sequence of the humansequence information from the canonical model organisms, such as Drosophila, will be to help interpret the sequence of the humansequence of the human genome.

The use of higher resolution techniques, such as array CGH and, soon, whole genome sequencing, will enhance the ability of researchers to examine stem cell lines to determine which are best — least likely to result in diseases and other problems — to use in creating therapies for use in humans.

The human genome has been heralded as the key to personalized medicine, but for the longest time complete sequencing of...

NHGRI's «Revolutionary Genome Sequencing Technologies» grants have as their goal the development of breakthrough technologies that will enable a human - sized genome to be sequenced for $ 1,000 orGenome Sequencing Technologies» grants have as their goal the development of breakthrough technologies that will enable a human - sized genome to be sequenced for $ 1,000 orgenome to be sequenced for $ 1,000 or less.

Many imprinted regions of the genome can contain sequence variants linked to human diseases, such as diabetes.

DNA sequencing costs have fallen more than 100-fold over the past decade, fueled in large part by tools, technologies and process improvements developed as part of the successful effort to sequence the human genome.

From widening the scope of model organisms to uncovering the inner workings of cells, for molecular biologists the human genome sequence has untold potential as a final frontier for exploratory science.