Sentences with phrase «sequencing studies on»

As part of ENCODE, 32 institutions did computer analyses, biochemical tests, and sequencing studies on 147 cell types — six fairly extensively — to find out what each of the genome's 3 billion bases does.

Not exact matches

The sequence of hacks specified in the study are the following; innovate (aid) money with cryptocurrency, turn rights into code on the blockchain, program aid money and agreements, and disrupt the aid model in general.

June 19, 2013 — A Cornell University study offers further proof that the divergence of humans from chimpanzees some 4 million to 6 million years ago was profoundly influenced by mutations to DNA sequences that play roles in turning genes on and off.

biochemical evidence such as Cytochrome - cyto - C is just one of the thousands of sequences and is not proof of common ancestry, as there are more variations than similarities in the genetic code, on the other hand a study of the amino acid make - up reveals that man is closer to lamprey than are fish.

With all due respect, if you'd read the actual study, you would see that this was not a whole genome sequence comparison; rather it was a comparison of mitochondrial 12S rDNA and 16S rDNA sequences for the purposes of confirming the species relationship between the Pod Mrcaru lizards (P. sicula), the source population from Pod Kopiste (also P. sicula), and the original indigenous population on Pod Mrcaru (P. mellisellensis).

After the study is done, the Germans put him on the shelf next to Hegel, Schelling, and Hermann Cohen (an important inspiration for Rosenzweig), so that they can continue their pedagogical task of instructing students in the sequence of philosophical stories.

Overall, a study of the genome sequences of 57 colorectal cancers showed, on average, 4.42-fold more somatic nuclear mitochondrial DNA as compared to matched healthy blood controls.

«From purely looking at the DNA sequences we can conclude that snakes retain many enhancers that, based on mammalian studies, we thought were limb enhancers,» says senior study author Douglas Menke, a geneticist at the University of Georgia.

Half of the patients treated in this study responded to either ponatinib (typically used for certain types of leukemia) or pazopinib (a kidney cancer drug), depending on the genetic alterations identified through sequencing.

In a study published in the May 29, 2014, edition of Molecular Ecology Resources, Duke researchers Peter Larsen, Ryan Campbell and Anne Yoder used high - throughput sequencing on sifaka blood samples to generate sequence data for more than 150,000 different sifaka antibodies — protective molecules that latch on to bacteria, viruses and other foreign invaders in the body and fight them off before they cause infection.

A comprehensive and technically sophisticated study published in the May 7 issue of Science, «A Draft Sequence of the Neandertal Genome,» by Max Planck Institute evolutionary anthropologists Richard E. Green, Svante Pääbo and 54 of their colleagues, demonstrates that «between 1 and 4 % of the genomes of people in Eurasia are derived from Neandertals» and that «Neandertals are on average closer to individuals in Eurasia than to individuals in Africa.»

«There's been a huge focus on studying ancient DNA from the sequence point of view.

To more accurately reflect the mechanisms driving oligodendrogliomas, the researchers used RNA sequencing to study directly, on a single - cell level, gene expression in samples from six early - stage human tumors.

They specifically studied the length of telomeres (repeated DNA sequences) on the ends of chromosomes in leukocytes (white blood cells); the protective caps are believed to be markers of biological aging, because they shrink over time.

This improves on current screening methods: A Lancet study last year showed that in 108 patients, the immune sequencing test could spot signs of relapse three to five months, on average, before the cancer was visible on a CT scan.

Subsequent genetic studies have supported the NCC deficit hypothesis, most recently an April report in Science on the sequencing of 14 ancient horse genomes up to 4,100 years old; that's close to the estimated dawn of domesticated horses some 5,500 years ago.

Unlike the previous studies that focused on certain species or a particular RNA virus, Skalka went broad: She and her colleagues surveyed every vertebrate genome available, 48 in all, and looked for hints of 5666 RNA viral sequences from 38 known families and nine genera that were unclassified.

The article constitutes the largest sequencing study to date on the genes of representatives from eight sponge genera covering all four currently recognized sponge classes.

As the authors of the new research explain: «There are three main levels of analysis in the study of proteins: the first is the sequence of amino acids, the second is the three - dimensional structure that these filaments take on a very short time after they are synthesized, while the third regards their function.

In this study, Tramelli and her colleagues used the recorded waveforms from the 2012 Emilia seismic sequence to simulate a seismic sequence that triggered end - to - end earthquakes along adjacent fault patches, observing the affect of continuous ruptures on the resulting ground motion and, consequently, its impact on critical structures, such as dams, power plants, hospitals and bridges.

For the study, the researchers used an unusually large dataset made up of the sequences of 128 proteins from 55 species, including representatives of all the major animal groups, focusing in particular on those that diverged very early.

Professor Gianni Liti, a senior author on the paper from the Institute for Research on Cancer and Ageing, Nice, said: «We were able to study the evolution in time by combining genome sequences of the cell populations and tracking the growth characteristics of the yeast cells.

Jeffrey Kidd, Ph.D., an Assistant Professor of Human Genetics and Computational Medicine & Bioinformatics who worked on the new study, notes that only recently has it become possible to sequence Y chromosomes, because of technical limitations of previous approaches.

With modern advances in DNA sequencing technology, detecting the presence of forest mammals based on DNA detection in the guts of invertebrates has become a potential approach to study the diversity of forest mammals.

Both studies relied on a popular lab organism known as C. elegans, a nearly microscopic nematode that is fast growing, translucent and has a sequenced genome showing that nearly half its genes are closely related to corresponding human genes.

In the current study, Huc and his colleagues have focused on enzymes that are generically capable of binding to DNA, irrespective of its base sequence.

In their studies on phylogenetics and biogeography, Besnard and his colleagues have also sequenced DNA from preserved plants in herbaria.

The DNA analysis used in this study focused on mitochondrial DNA, which is easier to recover from fossils than the DNA in chromosomes, because each cell has thousands of copies of the relatively short mitochondrial DNA sequence.

A stopped - flow spectrofluorometer was used to study the kinetics renaturation of nuclease from the acidified form on neutralization, the refolding is fast and the data can be described as a sequence of two first - order processes with half times of about 55 and 350 milliseconds, respectively.

«DNA sequencing is a powerful tool, but it is still quite expensive and has several technological and functional limitations that make it difficult to map large areas of the genome efficiently and accurately,» says Jason Reed, Ph.D., principal investigator on the study.

The new research focused on just nine genes, those most strongly associated with autism in recent sequencing studies, and investigated their effects using precise maps of gene expression during human brain development.

«Humans vary in their DNA sequences, and what is taken as the «normal» DNA sequence for reference can not account for all these differences,» says Stuart Orkin, MD, of Dana - Farber Boston Children's Cancer and Blood Disorders Center and co-corresponding author on the study with Matthew Canver, an MD - PhD student at Harvard Medical School.

Biotinylated probes are constructed based on these sequences to chemically «capture» the intron - containing genes from the study species» genome.

For the study, which was published in Nature Communications, the group performed whole genomic sequencing on 30 individual tumors classified as liver cancer displaying a biliary phenotype.

This study was based on DNA sequence and deep phenotypic data from the Simons Simplex Collection, a set of 2,760 families that have a single child affected by ASD.

Researchers have sequenced full genomes of three species — the golden orb - weaver, the African social velvet spider, and the common house spider — and have done more limited genetic and protein studies on many others.

The device has made it possible for researchers to study bacteria and viruses in the field, but its high error - rate and large sequencing gaps have, until now, limited its use on human cells with their billions of nucleotides.

Yet, «these studies using HeLa cells had to rely on information from the «reference» sequence produced by the Human Genome Project, even though there was evidence that the genomes of HeLa cell lines were probably quite different,» said Lars Steinmetz, Ph.D., who led the G3 study.

The project also serves as a model for other countries» efforts to sequence their people's DNA for research on personalized medical care, says study leader Kári Stefánsson, deCODE's CEO.

That, too, is unusual, especially given that on the tree of life, even primitive anaerobic fungi, like the three that underwent genome sequencing in this study, are evolutionarily much closer to humans than to bacteria.

This study uncovered non-coding RNAs» cancerous role by using high - throughput sequencing techniques to analyse reams of genetic information on normal and diseased tissue as part of the Cancer Genome Atlas project.

«We never would have seen that connection based on genetic sequences alone,» says Jack Johnson, a virologist at The Scripps Research Institute not involved with the study who first discovered the chain mail pattern in bacteriophages.

So geneticists have been focusing on the dog as a possible model for gene searches because this lack of sequence variation may help them circumvent a frequent problem with studies in humans.

Under the new plan, CDC, in a collaboration with the Association of Public Health Laboratories (an affiliation of U.S. state and local health labs), will put all sequence information on the several hundred different flu isolates it studies every year into publicly accessible databases such as GenBank as soon as possible.

Both studies rely on methods that attach molecular tags to all points in the genome where a double - stranded break has occurred, before sequencing the short, flagged segments to count the cuts in various genes.

Dr. James Beck of Wichita State University and Dr. John Semple, at the University of Waterloo, have collaborated on a new study highlighting the role of herbarium sampling coupled with cutting - edge next - generation sequencing technologies to better understand plant diversity.

This study further investigated the impact of nicotine use / smoking status and variation in the mu opioid receptor gene (OPRM1), specifically, an A118G single nucleotide polymorphism (SNP, or DNA sequence variation), on the effects of naltrexone on a range of drinking outcomes.

Dan Graur of Tel Aviv University bases his surprising claim on a study of genetic mutations, which produce changes in the amino acid sequence of the protein a gene codes for, and which are assumed to accumulate at a fairly steady rate.

Chaput's method of studying such sequences on a genome - wide scale involves first generating a DNA library of the entire human genome.

To uncover the interactive mechanisms between the host and influenza viruses, researchers sequenced the genome of a 10 - week - old female Beijing duck, and conducted transcriptomic studies on two virus - infected ducks.