Sentences with phrase «serine by the enzyme»

Not exact matches

One of the most potent compounds, WWL113, turned out to work principally by inhibiting Ces3, a serine hydrolase enzyme that scientists have not studied in the context of obesity or diabetes.

In this case, the researchers used a set of compounds, recently synthesized by Cravatt's laboratory, that tend to inhibit serine hydrolases — a vast enzyme family whose members participate in most biological processes in mammals.

Giulia Pontarollo and colleagues at the University of Padua provide new support for this hypothesis in their report in the Journal of Biological Chemistry that subtilisin, a serine protease secreted by Bacillus subtilis, is able to activate the human coagulation - promoting enzyme thrombin through a different mechanism than that used by human cells to activate it.