Sentences with phrase «serine hydrolase»
Crystal structure of an alpha / beta serine hydrolase (YDR428C) from Saccharomyces cerevisiae at 1.85 A resolution.
http://www.jcsg.org/
Serine Hydrolase Inhibitors Block Necrotic Cell Death by Preventing Calcium Overload of the Mitochondria and Permeability Transition Pore Formation.
One of the most potent compounds, WWL113, turned out to work principally by inhibiting Ces3, a serine hydrolase enzyme that scientists have not studied in the context of obesity or diabetes.
Ag85 is a group of serine hydrolases that plays a critical role in the incorporation of mycolic acids into the mycomembrane.
In this case, the researchers used a set of compounds, recently synthesized by Cravatt's laboratory, that tend to inhibit serine hydrolases — a vast enzyme family whose members participate in most biological processes in mammals.
Not exact matches
The study, which appears as a Nature Chemical Biology Advance Online Publication on March 28, 2016, began as an effort in the Cravatt laboratory to discover and characterize new serine / threonine hydrolases using fluorophosphonate (FP) probes — molecules that selectively bind and, in effect, label the active sites of these enzymes.