They add, that «by identifying and characterizing LMIT1 as a mitochondrial iron importer, we established a direct connection between iron uptake, mitochondrial redox balance and the development of virulence in Leishmania, significantly expanding future options for controlling
these serious human infections.»
Never mind that the agency's own panel of advisers urged that the drug be rejected, citing concerns that it could promote emergence of drug - resistant bacteria and that the drug belongs to an class of drugs needed as a last line of defense against
serious human infections.
Not exact matches
Premature infants who are fed with
human milk decrease their risks of a
serious and life - threatening intestinal
infection known as necrotizing enterocolitis, or NEC.
Excessive and unnecessary use of the drugs, which are similar to what doctors prescribe for people's ear
infections, strep throats and other illnesses, can lead to super-resistant strains of bacteria that can cause
serious human diseases that have no cure.
To determine whether a completely
human milk based diet during the first 10 days of life reduces the combined incidence of
serious infection, NEC, and mortality as compared to formula feeding and 2.
Studies have shown that a protein in
human milk aids in brain development, and breast - fed babies are less likely to get gastrointestinal
infections and diarrhea, respiratory and ear
infections or more
serious diseases such as pneumonia, and there is a lower risk of Sudden Infant Death Syndrome.
Paul Ewald points out that any conditions allowing germs to be transported from a person immobilized by
serious illness to new
human hosts can produce deadly
infections.
«RNA interference is activated in
human response to influenza, other important viruses: Discovery could lead to better ways of combating
serious infections, including Ebola and Zika.»
Invasive aspergillosis (IA) is a
serious disease of immune - compromised individuals and the most common invasive mold
infection in
humans.
Both E coli O157 and Salmonella
infections in
humans have been linked with
serious illnesses.
The research, published online today in the journal Clinical Infectious Diseases, shows that poultry may be a source of
human exposure to MRSA, a superbug which can cause
serious infections and even death.
While antibiotic resistance genes are not harmful in themselves, they limit the use of antibiotics for treating bacterial
infections and pose a
serious threat to global public health if they get transmitted to
humans from environmental sources, such as compost.
Geneticists now think that this aberration survived because it protected early
humans against
serious infections that arose from more crowded living conditions.
More commonly known as
human herpesvirus 5 or HCMV, cytomegalovirus is the most frequently transmitted intrauterine
infection and can result in
serious disabilities at birth, though most people will exhibit only mild symptoms or none at all.
While most West Nile Virus (WNV)
infections in
humans are asymptomatic and go unnoticed, the virus causes
serious and sometimes fatal neurologic illness in some people.
Prompt treatment, ideally within 24 hours of an animal or
human bite, can prevent
serious injury or
infection:
Persistent bacterial
infections pose
serious health problems for
humans, including Cystic Fibrosis patients.
• Patients must have adequate coagulation (international normalized ratio (INR) or prothrombin time (PT), partial thromboplastin time (PTT) ≤ 1.5 times ULN) • Adequate liver function (total bilirubin ≤ 1.5 times the ULN, alanine aminotransferase (ALT) and aspartate aminotransferase (AST) ≤ 2.5 times ULN Exclusion Criteria: • Presence of active / uncontrolled central nervous system involvement • History of clinically significant cardiac disease; uncontrolled hypertension • Left ventricular ejection fraction (LVEF) < 45 % • Allogeneic stem cell transplant within 100 days before first dose of study drug • Known history of
human immunodeficiency virus (HIV)
infection • Chronic or active hepatitis B or C, requiring antiviral therapy • Evidence of history of bleeding disorder, dialysis, or coexisting cancer that is distinct in primary site or histology from the cancer evaluated in this study •
Serious, uncontrolled
infection • Unresolved chronic toxicity > grade 1 from prior therapy • Use of strong CYP3A4 inhibitors or strong inducers within 7 days prior to the start of study treatment and for the duration of the study
The virus, commonly known as VSV, can infect cattle, but it rarely causes
serious infections in
humans.
Most importantly it has been noted that the surgical instruments used during the FGM procedure are not sterilized, a fact that can cause
serious and sometimes even fatal
infections and diseases such as septicemia and HIV (
human immunodeficiency virus)(Alston, et al, 2007 p. 547).
Sometimes the size of a pinhead, flea bites have been known to cause such
serious afflictions in
humans as dermatitis, anemia, Rickettsioses, secondary
infection at the wound site and — at their most severe — plague.
It should be noted that Lyme disease
infection is usually even more
serious with
humans, so protecting yourself is worth remembering as well.
Humans also have bacteria in their mouths, but cats can pass on particular forms of bacteria — including one that causes «Cat - Scratch Disease,» an
infection that generally does not cause
serious symptoms in healthy adults.
It should also be noted that
human infection by this parasite is especially
serious (see below).
Human infection by this parasite is especially
serious (see below).
More
serious ailments in
humans include arterial
infections, endocarditis, arthritis, muscle pain, eye irritation and urinary tract symptoms.
«As with the
human influenza, there is a risk for secondary bacterial
infections which can be
serious.
The
infection is
serious, contagious to
humans, and exposure generally involves urine contamination of outdoor puddles of water by wildlife or other dogs.