Sentences with word «serotype»

The monkey model has its own limitations: Monkeys don't develop severe disease when infected with different serotypes of dengue virus, which clearly happens in humans.

They find statistical support for high viral infectivity rates of dengue serotypes 2 and 3 relative to dengue 1.

DENV can cause severe disease, especially in people who have previously been exposed to a different serotype of the virus.

Fibriansah et al. report that a human antibody (2D22) specific for DENV serotype 2, when given therapeutically, can protect mice from a lethal form of this virus.

The dominant hypothesis to explain this has been that the antibodies from the first infection react with the new serotype in a way that worsens the damage.

To assess cross-neutralization of TMAdV by known human adenoviruses, 7 pools of in - house reference sera at the VRDL (rabbit hyperimmune sera) and collectively containing antibodies to human adenovirus serotypes 1 through 35 were available for testing.

The four dengue virus serotypes (DENV1 to DENV4) are mosquito - borne flaviviruses that cause up to ~ 100 million cases of dengue annually worldwide.

The investigation is complicated by the fact that the outbreak has apparently been caused by a very rare EHEC serotype called O104.

Such antibodies are expected to reduce the efficacy of vaccines based on common human serotypes of adenovirus in a human target population.

There are at least four types of dengue known as serotypes.

Now, they're moving forward with the same studies for serotypes one, three and four.

These viruses do not circulate in the human population and fail to carry neutralizing B cell epitopes that cross-react with the common serotypes of human adenoviruses.

The same thing happens if a person has been infected with two or more serotypes.

But those who become infected with a second serotype later are at risk of dengue hemorrhagic fever / dengue shock syndrome (DHF / DSS), which can cause massive fluid loss, organ failure, and death.

Human parainfluenza viruses (HPIVs) are a group of four distinct serotypes of single - stranded RNA viruses belonging to the paramyxovirus family.

Each nanoparticle was studded with copies of DENV2 - E protein, a key protein from serotype 2 of the virus.

He and other researchers are now trying to develop a more rapid and specific test for the rare serotype.

The investigation documented Salmonella serotype Enteritidis (SE) infection associated with eating improperly prepared turkey and stuffing containing eggs and emphasizes the need to use a meat thermometer to ensure complete cooking of turkey and stuffing.

The DNA - based multiplex diagnostic test will enable rapid diagnosis and confirmation of dengue, as well as identify the specific serotype of dengue causing the infection.

But for poorly understood reasons, subsequent exposure to a second dengue serotype increases the chance of the illness progressing to the severe and sometimes fatal dengue hemorrhagic fever.

The high prevalence of natural dengue infections in endemic areas means that many people have experienced infection at some point in the past and therefore may have immunity to the infecting serotype.

«This fits nicely with the concept raised by Screaton that Zika virus in this context could be considered as a fifth serotype of dengue.»

Rotavirus - specific cytotoxic T lymphocytes cross-react with target cells infected with different rotavirus serotypes.

Recognized as the first global proteomic analyses of time course responses of mouse macrophages to S. enterica serotype Typhimurium (S. Typhimurium) infection, the study may lead to new strategies for diagnosing, treating, and vaccinating against infectious disease.

«With dengue, you need to vaccinate people against all four serotypes at once in order to protect people.

Testing at the USDA National Veterinary Services lab in Ames, Iowa, confirmed the New Jersey serotype of virus in the affected horses.

They find a role for viral replication in explaining serotype - specific differences in viral load — according to a new study published in PLOS Computational Biology.

Its goal is the development and characterization of novel vaccine carriers to HIV - 1 antigens based on El - deleted adenoviral recombinants derived from chimpanzee serotypes in pre-clinical animal models.

It is usually not fatal, but in areas where there is more than one serotype circulating, it is more likely to produce a severe, potentially life - threatening illness.

A first infection is usually mild, but a second infection with a different serotype puts the patient at risk of a serious, occasionally life - threatening illness.

Once the short - term immunity to the other three serotypes wears off, the survivor is at greater risk for more severe disease from a subsequent infection.

On the other hand, immunization of mice with recombinant NS1 from each of the four serotypes protected mice against vascular leak and the lethal effects of dengue virus type 2.

Researchers at The University of Queensland have shown how Botox — also known as Botulinum neurotoxin serotype A — is transported via our nerves back to the central nervous system.

One such passenger is dengue virus (DENV), which infects up to 400 million people each year and comes in several serotypes (1 to 4) and disease presentations — from mild infection to severe disease and sometimes death.

Severe disease is thought to result from immunopathogenic processes involving serotype cross-reactive antibodies and T cells that together induce vasoactive cytokines, causing vascular leakage that leads to shock.

In human endothelial cell monolayers in culture, NS1 from any of the four DENV serotypes triggered endothelial barrier permeability.

neoformans (serotype D) did not affect melanin production and the MN35 strain was equally virulent as the wild - type.

In our study, 2 of 81, or 2.5 % of random adult blood donors exhibited borderline titers of neutralizing antibody to TMAdV, indicating either a low prevalence of TMAdV in the human population or cross-reactivity to a related virus (although no evidence of cross-reactivity was found with HAdV serotypes 1 through 35).

Immune response of infants to bovine human rotavirus serotype G1 reassortant WI79 - 9: the dose response pattern to virus surface protein vp7 differs from that to vp4.

Lysogene's most advanced product is rAAV vector serotype rh.10 carrying the human N - sulfoglucosamine sulfohydrolase (hSGSH) for the treatment of the mucopolysaccharidosis type IIIA (MPS IIIA) or Sanfilippo syndrome type A. Lysogene's gene therapy is delivered directly to the CNS in one neurosurgical procedure.

Morphologic and phenotypic characteristics of myocarditis in two pigs infected by foot - and mouth disease virus strains of serotypes O or A.

Such serotypes of adenovirus do not circulate in the human population.