Previous TCGA research showed that a form of ovarian cancer (high - grade
serous ovarian carcinoma) and a subtype of breast cancer (basal - like breast cancer) share many genomic features.
The Cancer Genome Atlas research network published a landmark study of high - grade
serous ovarian carcinoma, the first of several common cancers to be characterized by TCGA.
Not exact matches
For the new study, described in the October 23rd issue of Nature Communications, scientists at the Johns Hopkins Kimmel Cancer Center and Dana Farber Cancer Institute in Boston collected tissue samples containing normal cells,
ovarian cancers, metastases that had spread elsewhere, and small cancers found in the fallopian tubes, which included single cell layers of cancer called «p53 signatures» and
serous tubal intraepithelial
carcinoma, or STIC lesions.
To date, the TCGA Research Network has generated data and published analyses on glioblastoma multiforme,
ovarian serous adenocarcinoma, colorectal adenocarcinoma, lung squamous cell
carcinoma and invasive breast cancer.
Most
ovarian cancers are
serous carcinomas, which develop in the tissue lining the ovaries and are subtyped into high - grade and low - grade.