Sentences with phrase «serous ovarian tumors»
But mutations, which are found in 96 percent of patients with high - grade serous ovarian tumors, can cause p53 to form clumps, or «aggregates,» which impair the protein's normal function.
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Importantly, elevated BRCA1 methylation was confined to patients diagnosed with so - called high - grade serous tumors, the most aggressive variant of ovarian cancer, which also is the variant associated with BRCA1 mutations.
A section of a tumor organoid grown from cells derived from a patient with high - grade serous ovarian cancer (left) and a mini-tumor treated with ReACp53, resulting in extensive cancer cell death.
«We think that by isolating the CA125 - negative tumor cells we have uncovered this reservoir of carboplatin - resistant high - grade serous ovarian cancer cells.»
Association and prognostic significance of BRCA1 / 2 - mutation status with neoantigen load, number of tumor - infiltrating lymphocytes and expression of PD - 1 / PD - L1 in high grade serous ovarian cancer.