Sentences with phrase «serum gonadotropin»

Not exact matches

Inclusion Criteria: • Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1 • Have histologically or cytologically confirmed advanced or metastatic non-small cell lung cancer (NSCLC)(Stage IIIb or greater) • Measurable disease, as defined by Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 • Known PD - L1 tumor status as determined by an immunohistochemistry (IHC) assay performed by the central laboratory on tissue obtained at Screening • A woman of childbearing potential must have a negative highly sensitive serum (beta - human chorionic gonadotropin [beta - hCG]-RRB- at Screening within 14 days prior to study drug administration Inclusion Criteria for Crossover: • Participants must have been randomized to Arm A of the study and had radiographic disease progression according to RECIST 1.1 • Participants must have a mandatory biopsy at the time of disease progression according to RECIST 1.1 prior to crossing over.

The negative effects seem to lie in the capacity of some foods / nutrients to stimulate proliferative pathways that in turn stimulate development of acne — suspect foods include those with a high glycaemic load and milk.11, 43, 44 Other evidence comes from several studies reporting that the prevalence of acne varies significantly between different populations and is substantially lower in non-Westernized populations that follow traditional diets, 45 a common factor among these traditional diets being a low glycaemic load.46 Various studies have provided evidence that high - glycaemic - load diets are implicated in the aetiology of acne through their capacity to stimulate insulin, androgen bioavailability and insulin - like growth factor - 1 (IGF - 1) activity, whereas the beneficial effects of low - glycaemic - load diets, apart from weight and blood glucose levels, also include improved skin quality.44 The clinical and experimental evidence does in fact suggest ways in which insulin can increase androgen production and affect via induction of steroidogenic enzymes, 47 the secretion by the pituitary gland of gonadotropin - releasing hormone and the production of sex hormone - binding globulin.48 Insulin is also able to reduce serum levels of IGF - binding protein - 1 increasing the effect of IGF - 1.49 These insulin - mediated actions can therefore influence diverse factors that underlie the development of acne such as:

Developmental processes in early adolescence: Relations among chronologic age, pubertal stage, height, weight, and serum levels of gonadotropins, sex steroids, and adrenal androgens