When Vojdani et al. measured IgG and IgA antibody levels against zonulin at the same time points (zero, six, 24, and 30 hours), they found that
serum zonulin was somewhat correlated with anti-zonulin IgG and highly correlated with anti-zonulin IgA.
For the other two thirds of the participants (12/18),
serum zonulin levels fluctuated significantly between blood samples.
For example, a close look at the data from one study finds that only 42 percent of the patients with type 1 diabetes had an elevated
serum zonulin level (defined as 2 standard deviations above the control group mean)(13).
Celiac disease patients have higher concentrations of
serum zonulin during the acute phase of disease compared with their healthy counterparts, and also have over-expressed CXCR3, the intestinal receptor for gliadin (Fasano, 2011).
Not exact matches
One test that has grown rapidly in popularity is the measurement of
serum or plasma
zonulin.
Some alternative practitioners also offer a blood (
serum) test for antibodies to various large molecules, including actomyosin, occludin,
zonulin, and lipopolysaccharides.