Sentences with phrase «serve as biomarkers»

Tinkering with gene switches can have a profound effect on how they behave, and labs around the world are now scanning the genome in hopes of identifying epigenetic modifications — sometimes called «marks» or «tags» — that could serve as biomarkers, helping to predict and identify a wide range of conditions.

«We began to mine the data to look for metabolites that might serve as biomarkers or as therapeutic targets,» Chinnaiyan explained.

Researchers believe that mutations in this complex could serve as biomarkers to predict response to rapamycin treatment in cancer patients.

These results suggest that miR - 7 and KLF4 may serve as biomarkers or therapeutic targets for brain metastasis of breast cancer.

«Furthermore, the insulin - specific TFH cells could serve as biomarkers to determine the treatment success of the insulin vaccinations we perform.»

The findings, which appear in the journal Alzheimer and Dementia, point to new biological pathways that may be implicated in AD and could serve as biomarkers for risk of the disease.

In one VA - funded study, he is using a type of electroencephalography (EEG)-- in which veterans wear an electrode - studded cap on their head — to trace brain patterns that may eventually serve as biomarkers.

Blood contains proteins, enzymes, lipids, metabolites, and peptides that serve as biomarkers for health screening, monitoring and diagnostics.

The authors say these sets of proteins can serve as biomarkers for monitoring autophagy in the clinical setting.

«In addition to the potential of these genes and gene products to help us design new drugs, they could also serve as biomarkers for accurate diagnosis,» she says.

Human sperm may hold the potential to serve as biomarkers of the future health of newborn infants, according to a new study by a Wayne State University School of Medicine research team.

Peripheral inflammatory responses may, then, serve as biomarkers and thus serve as targets of immune - based therapies for depression.

In particular, the PTPRF gene, which is known to suppress intracellular signals that are usually triggered by insulin binding to its receptor on the cell surface, may serve as a biomarker linking insulin resistance with insufficient milk supply.

In particular, protein tyrosine phosphatase, receptor type, F (PTPRF) may serve as a biomarker linking insulin resistance with insufficient milk supply.

Furthermore, this can also serve as a biomarker to stratify patients for treatment.

So A1c serves as a biomarker, indicating average blood glucose levels over a two - to three - month period.

Lin28 may serve as a biomarker for such treatment - resistant tumors.»

«Our findings suggest that PD1could serve as a biomarker as well as a much needed antiviral drug for severe and lethal influenza virus infections,» Imai says.

But in ACS Central Science, researchers reveal that an enzyme already implicated in a host of neural disorders could someday serve as a biomarker.

«This is how we can start thinking about precision medicine in action,» said the study's senior author, Alice S. Chen - Plotkin, MD, an assistant professor of neurology at Penn. «We found that a relatively common genetic variation can both serve as a biomarker for and influence the disease course of Parkinson's patients.

Previous research has shown that eye movements in response to visual stimuli can serve as a biomarker for brain states such as fatigue or high mental concentration.

They immunized them with the antigen α - fetoprotein, which is found in 70 - 80 percent of human liver cancers, and serves as both a biomarker for diagnosing and a target for treating the sixth most common cancer worldwide, He says.

Akassoglou also thinks fibrinogen and other blood clotting proteins could serve as a biomarker for MS.. A biomarker is a measurable indicator of the presence or severity of a disease, enabling physicians and researchers to track disease progression.

90 % of ingested iodine is excreted via renal pathways, such that median spot urinary iodine concentrations (UIC) will serve as a biomarker for recent dietary iodine intake (1).

Not exact matches

Each reservoir has specific amounts of different biomarkers, so oil biomarkers serve as identifiers much like human fingerprints.

Although tau imaging is still in its earliest stages, Ryan hopes that such imaging will accelerate drug development and that finding a blood - based biomarker for Alzheimer's to reveal risk (much like cholesterol serves as a marker for cardiovascular risk) will change the field dramatically in terms of how doctors can diagnose the disease.

In the end, the identification of microbial species or metabolites that are altered in Parkinson's disease may serve as disease biomarkers or even drug targets, and interventions that correct microbial imbalances may provide safe and effective treatments to slow or halt the progression of often debilitating motor symptoms.

«Since these touchscreens can detect very small capacitance changes we thought they could serve as highly sensitive detection platforms for disease biomarkers,» says Park.

«This may serve as a clinically useful biomarker to identify a subset of difficult - to - treat asthmatic children, and targeting the VNN - 1 pathway may be useful as a therapeutic strategy.»

Plasma levels of this biomarker rose with kidney deterioration in patients with MMA, and may serve as a valuable indicator of MMA kidney disease progression in the clinic.

This situation is confounded by the relative scarcity of blood - or cerebrospinal fluid (CSF)-- based biomarkers that can increase our understanding of disease pathology, and might also serve as effective differential diagnostic or prognostic tools.

In previous studies, the same group along with others had demonstrated that microRNAs (miRNAs) produced by eukaryotic cells and viruses are present in human blood in highly stable, cell - free forms and these so called circulating miRNAs can serve as non-invasive biomarkers for the early diagnosis of various diseases, including viral diseases.

This microRNA — miR -124-3p — is thus a potential therapeutic target for novel drug development, and it can serve as a putative biomarker for MDD pathogenesis.

«This suggests that MAO - B activity in peripheral blood cells of a patient might serve as an accessible and economical biomarker to evaluate the potential risk of an individual for this disease,» said Assoc Prof Lim.

«Our present study shows examination of the gene expression profiles at the very early age of initial clinical detection reveals both strong evidence of early biological processes in ASD and abnormal signals with the potential to serve as an early, practical biomarker of risk for the disorder in general pediatric settings.»

Also, such connectivity could serve as a clinical biomarker to identify smokers who are most likely to respond to a particular treatment.

Bettcher said the new findings could possibly serve as the focus of more in - depth studies aimed at developing a blood test to detect inflammation biomarkers years before symptoms of Alzheimer's appear.

Their new study points to a biomarker in the cellular machinery that could not only serve as an early warning of colon cancer, but potentially be harnessed to counteract advanced forms of the disease, the second - largest cause of cancer death in the U.S.

Therefore, it is useful to identify tumor features that can serve as «predictive biomarkers» to forecast how a person's tumor might respond to a particular treatment.

With further research, the team says the concept could be adapted to monitor other biomarkers besides calcium, to serve as early warning systems for other gradually - developing illnesses like neurodegenerative diseases and hormonal disorders.

«We need to figure out the exact mechanisms by which miR200 regulates the DNA repair process and also determine if miR200 can be detected in the bloodstream and serve as an effective biomarker for complications,» says Dr. Kulkarni.

The research is significant for humans, said Baranzini, because the presence or absence of Tob1 in CD4 + cells could eventually serve as a prognostic biomarker that could help clinicians predict the course and severity of MS in individual patients.

Circulating cell - free DNA (cfDNA) isolated from plasma or serum by noninvasive procedures can serve as a «liquid biopsy» and has potential as a biomarker for the tumor burden and survival prediction of breast cancer (BC).

Importantly, newly identified proteins will serve as disease biomarkers and will contribute to the development of novel therapeutic strategies.

Their work encompasses several strategies, including: developing FL - HCC animal models to characterize tumor - immune interactions, exploring if a mutated protein associated with FL - HCC could be targeted by immunotherapy, identifying immune checkpoints that could potentially serve as targets for immunotherapy as well as biomarkers for analyzing patients, and evaluating the effectiveness of immunotherapy strategies against FL - HCC patient samples in the lab.

A new plasmonic sensor developed by researchers at the University of Illinois at Urbana - Champaign will serve as a reliable early detection of biomarkers for many forms of cancer and eventual... Read more

She also serves as a member of several biomarker advisory boards.

These results serve as a rationale for ONC201 single - agent trials in relapsed / refractory acute leukemia, non-Hodgkin's lymphoma, MM and combination trial with dexamethasone in MM, provide pharmacodynamic biomarkers and identify further synergistic combinatorial regimens that can be explored in the clinic.

But the most important implication of our findings would be to use STAT5 as the target for chemoprevention, in which case it would also serve as the optimal biomarker.

DHEA serves as a good biomarker for androgen production.