Sentences with phrase «serve as tumor»
Not exact matches
His work indicates that this cell surface marker could serve as a target for a novel brain cancer vaccine or T - cell therapies engineered to recognize and kill tumors carrying that neoantigen.
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«Nonetheless, the proof of concept studies we have obtained thus far are extremely encouraging, and we are confident that with proper support and efforts we could translate our findings into experimental therapeutics for a variety of solid tumors that are driven by EphA2 overexpression, including breast, lung, prostate, pancreatic, and ovarian cancers,» said Pellecchia, who serves as the founding director of the Center for Molecular and Translational Medicine at UCR.
Pre-clinical studies have shown that ALT - 803 activates the immune system to mobilize lymphocytes against tumor cells and could potentially serve as an important component in combination treatments.
The pathologist of the Department of Pathology at the University Hospital of Bellvitge August Vidal explained that «this tumorigenic transformation depends on Dicer protein that could serve as a marker for the presence of tumor cells, or as a therapeutic target.»
«We used the algorithms to identify typical molecular signatures of stem cells [stemness signatures] that could help us understand tumors and serve as predictors of aggressiveness or clinical outcome.»
This analysis suggests that a rare subset of tumor cells harbor different genetic alterations and that those cells serve as the seeds for the recurrence of rhabdomyosarcoma.»
Lin28 may serve as a biomarker for such treatment - resistant tumors.»
This transformation recognizes that the immune inflammatory state serves as a key mediator of the middle stages of tumor development.
Hockfield came to MIT from Yale University, where she spent 20 years studying brain development and brain tumors and served as provost.
This scar tissue can serve as a protective barrier for pancreatic cancers, allowing tumors to resist chemotherapy and evade the body's own immune system.
«Protein serves as natural boost for immune system's fight against infection, tumors.»
«Thus, we have proven that Tie2 on pericytes serves as a growth brake for vessels and, hence, also for tumors,» said Laura Milde, who is one of the first authors of the publication.
Certain molecules on tumors can serve as targets for attack by cells of the immune system.
Therefore, it is useful to identify tumor features that can serve as «predictive biomarkers» to forecast how a person's tumor might respond to a particular treatment.
One group of small, non-coding RNA molecules could serve as a marker to improve cancer staging and may also be able to convert some advanced tumors to more treatable stages, report a University of Chicago - based research team in the April 1, 2008, issue of the journal Genes & Development.
Dr. Kunle Odunsi is the deputy director of the Roswell Park Cancer Institute, where he also serves as the chair of the Department of Gynecologic Oncology, the executive director of the Center for Immunotherapy, and the co-Leader of the Tumor Immunology and Immunotherapy research program.
The enzyme «isn't just a random by - product of a tumor — it's something that can serve as a marker for growth and malignancy,» says Ester Kwon, a former postdoctoral researcher in Bhatia's lab.
Dr. Ehrlich serves as the Director of the Pediatric Trauma and is a member of the Solid Tumor Oncology Program at CS Mott Children's Hospital at the University of Michigan.
That means the mice should be able to serve as a new test bed for treatments aimed at shrinking children's tumors.
Circulating cell - free DNA (cfDNA) isolated from plasma or serum by noninvasive procedures can serve as a «liquid biopsy» and has potential as a biomarker for the tumor burden and survival prediction of breast cancer (BC).
A surgeon, educator and researcher, Kandel comes to UChicago Medicine from Columbia University College of Physicians and Surgeons in New York where she served as the R. Peter Altman Professor of Surgery and Pediatrics in the Institute for Cancer Genetics and co-director of its Pediatric Tumor Biology Laboratory.
More importantly, Tregs isolated from patients» tumors were studded with higher - than - normal levels of the immune molecule CCR8, which serves as a trigger for Tregs.
In all negative tumors, occasional positive tumor cells or coexisting reactive lymphocytes were present and served as internal positive controls (arrows in C, right).
Their work encompasses several strategies, including: developing FL - HCC animal models to characterize tumor - immune interactions, exploring if a mutated protein associated with FL - HCC could be targeted by immunotherapy, identifying immune checkpoints that could potentially serve as targets for immunotherapy as well as biomarkers for analyzing patients, and evaluating the effectiveness of immunotherapy strategies against FL - HCC patient samples in the lab.
The lab also found that apoptotic tumor cells serve as potent instigators of the T cell immune response and has worked on developing cancer vaccines to mimic PND tumor immunity.
Spheroids serve as models for the development of healthy tissues and their maintenance in the living organism but also as models for tumor growth (Pampaloni et al. 2007).
Prior to his appointment as cancer center director, Gilbertson served as the founding director of the hospital's Molecular Clinical Trials Core and co-leader of the Neurobiology and Brain Tumor Program.
This study design will establish whether (1) DAXX can serve as a marker for early tumor growth or later advanced / metastatic PCa, and (2) high DAXX expression associates with indolent versus lethal PCa.
Christina Curtis, PhD, MSc is an Assistant Professor in the Departments of Medicine (Oncology) and Genetics at Stanford University School of Medicine where she leads the Cancer Systems Biology Group and serves as Co-Director of the Molecular Tumor Board at the Stanford Cancer Institute.
Wistar researchers also create new tools for melanoma research, including three - dimensional «artificial skin» that serves as a model for studying how living tumors behave, as well as a proving ground for new therapeutics.
He served as co-chair of the Tumor Virology Program of the Abramson Cancer Institute.
Areas of focus include: understanding how tumour - reactive T cells and B cells promote patient survival in cancer; defining the effects of standard treatments on tumor immunity; and using genomic approaches to identify novel tumour mutations that can serve as target antigens for immunotherapy.
Therefore, we hypothesized that NSCs could serve as an ideal cellular delivery platform for targeting antibodies to malignant tumors.
Old, who also heads the Ludwig Institute for Cancer Research (LICR) New York Branch and has served for many years as director of LICR's worldwide scientific programs, says that, eventually, vaccines will treat a wide variety of cancer types, recruiting the immune system to stop the progression of patients» tumors and helping to fully stabilizing the disease.
Polyphenols have been shown to reduce oxidative stress, may inhibit tumor cell replication and can combat toxicity from certain pollutants, such as dioxins, which serve as endocrine disruptors.
Dogs are also helping advance the fight against human cancer as they serve as a model for various human tumors.
The bacteria serves as a delivery system to introduce the cancer marker to the patient's immune system and instruct it to eliminate the tumor cells that express this marker.
These results suggest that tumor antigen loaded CD40 - B may serve as a practical alternative to DC in cell - based vaccine strategies for both dogs and humans with cancer.