Sentences with phrase «sestrin gene activation»
First, we will use our unique DNA - and chromatin - templated in vitro transcription systems to investigate the direct role of p53 serine18 phosphorylation in sestrin gene activation through modulation of p53 - coactivator interactions.
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The anti-senescence function of p53 involves direct activation of sestrin genes, which encode proteins that regulate ROS levels and the AMPK / mTOR pathway.