Sentences with phrase «several animal models of»

Selective 5 - hydroxytryptamine 2C receptor agonists derived from the lead compound tranylcypromine: Identification of drugs in several animal models of CNS related disorders.

Indeed selected compounds demonstrated efficacy in several animal models of CNS related disorders such as depression, obesity, addiction, and psychosis.

Not exact matches

Using data from several sources on 162 terrestrial animals and plants unique (endemic) to the Albertine Rift, the researchers used ecological niche modeling (computer models) to determine the extent of habitat already lost due to agriculture, and to estimate the future loss of habitat as a result of climate change.

And several attempts to carve a new target from a family of enzymes called p38 kinases have also failed, despite favorable results in animal models.

The animal rights advocacy group People for the Ethical Treatment of Animals (PETA) has been calling for a ban for several years, arguing that computer models and simulations can effectively replace dissection.

Though Atala always remains circumspect about the status of his projects, he says this partial transplant model is different: That team is far along in the process, successfully placing kidney cartridges into animals for trials lasting several months.

Similar findings were present in the cerebral cortex and other regions of the brain in these animals and also found in several other mouse models of diabetes.

All together INRA facilities power up (1) Research in multi-disciplinary domains through academic and industrial collaborations for the development of large animal models, therapeutics or new imaging devices, and (2) Training under several topics (biocontained experiments, introduction of new imaging methods for large animal models etc.), welcoming external teams which do not possess such an instrumental park for Transnational access.

Dean LaFerla has several research interests, including the molecular biology of Alzheimer's disease and other neurodegenerative disorders, presenilins and calcium signaling, learning and memory, and transgenic and genetically modified animal models.

Dr. Tarazi and his group have also established several animal models that provide close presentations of the core symptoms of neuropsychiatric conditions, and have efficiently utilized these models for assessing the actions of standard and experimental medications.

This network is composed of a central animal facility (PBES) and several technological platforms: production of mutant animals, vectorology and genetic analysis as well as infectious models analysis.

Having a strong R&D department with great experience and expertise in drug development, animal model and assay development and preclinical efficacy evaluation, the contribution of Biomedcode has been greatly valued by our partners, as documented by our participation in several collaborative research projects.

In the paper, the authors use several animal models to show that the progenitor cells could contribute to the formation of new lymph ducts, both by becoming part of the lymph ducts and by stimulating the growth of nearby cells.

In 1995, University of Chicago researchers demonstrated that gene therapy, using a virus, could be used to combat restenosis following angioplasty in several animal models.

Their work encompasses several strategies, including: developing FL - HCC animal models to characterize tumor - immune interactions, exploring if a mutated protein associated with FL - HCC could be targeted by immunotherapy, identifying immune checkpoints that could potentially serve as targets for immunotherapy as well as biomarkers for analyzing patients, and evaluating the effectiveness of immunotherapy strategies against FL - HCC patient samples in the lab.

We developed several computational and machine learning methods to successfully identify behavioral patterns or signatures associated with different classes of reference drugs, from which to predict the class of novel compounds (Brunner et al., 2012, Alexandrov et al., 2015), and more recently developed methods to allow us to compare animal models of AD and its progression, and to identify (in silico) novel compounds from our existing database of thousands of novel and reference compounds with the potential to reverse the AD model behavioral profile.

We discovered several Eph receptors and ephrins, and research in our laboratory is dedicated to the characterization of Eph receptor signal transduction mechanisms and biological functions using biochemical, mass spectrometry, molecular biology and cell biology approaches in conjunction with animal models.

So far, we've seen gene silencing drugs tested in several different animal models of Huntington's disease, successfully delaying symptom onset or even reversing symptoms.

Future models, it seems, will come in many varieties, ranging from several kinds of animals to in vitro systems to computers, with each approach building on the others.

There are currently no disease - modifying treatments that have been shown to slow the progression or delay the onset of HD in humans; however, several compounds have demonstrated promise in animal models of HD.1 Robust and sensitive markers of disease progression are required to assess their efficacy in humans.

In the mouse model of MS, experimental autoimmune encephalomyelitis (EAE), positive effects of modified fasting and ketogenic nutrition on disease onset and clinical course in animals have been observed in several studies.

Several studies done on animal models have suggested that the principal compound in cilantro, linalool, has an ability to revamp and boost the antioxidant function of the liver.

Several charming models, from superb high - top sneakers, cool slip - ons, flat espadrilles, classic derbies, and loafers to the most sporty glam boots and other fashionable footwear embellished with spikes or studs, strass, metallic animal prints and other signature details of the house in trendy, modern colors.

According to Hansen, any large metropolitan area will have several different welfare models to handle the overpopulation of animals.

After working for several decades in upstate New York doing non-invasive studies of animal models of inherited bleeding diseases, she moved to southern California in 1986 to start Hemopet, the first non-profit national animal blood bank.

While applied animal behaviorists may have been trained in a particular theoretical tradition, more often than not, they are required to combine, and apply the theories and approaches to an understanding of animal behavior developed through several different approaches and models.

After working for several decades in upstate New York doing non-invasive studies of animal models of inherited bleeding diseases, she moved to southern California in 1986 to start Hemopet, the first nonprofit national animal blood bank.

In humans, both the HPA system and the autonomic nervous system show developmental changes in infancy, with the HPA axis becoming organized between 2 and 6 months of age and the autonomic nervous system demonstrating relative stability by 6 to 12 months of age.63 The HPA axis in particular has been shown to be highly responsive to child - caregiver interactions, with sensitive caregiving programming the HPA axis to become an effective physiological regulator of stress and insensitive caregiving promoting hyperreactive or hyporeactive HPA systems.17 Several animal models as well as human studies also support the connection between caregiver experiences in early postnatal life and alterations of autonomic nervous system balance.63 - 65 Furthermore, children who have a history of sensitive caregiving are more likely to demonstrate optimal affective and behavioral strategies for coping with stress.66, 67 Therefore, children with histories of supportive, sensitive caregiving in early development may be better able to self - regulate their physiological, affective, and behavioral responses to environmental stressors and, consequently, less likely to manifest disturbed HPA and autonomic reactivity that put them at risk for stress - related illnesses such as asthma.