We established
several cell lineages from three independent transfection experiments and chose three lines (iPSC1, iPSC2, iPSC3) for further characterization.
Not exact matches
«If ctenophores diverged first, these organ systems likely have been present in the common ancestor of all animals — and sponges and placozoans must subsequently have lost them — or complex traits like nerve
cells and muscles must have emerged independently
several times in different
lineages,» Wörheide explains.
In this process,
several hundred times more
cells of the so - called myeloid
lineage (thrombocytes, erythrocytes, granulocytes, monocytes) form than long - lived lymphocytes (T
cells, B
cells, natural killer
cells) do.
Recently,
several observations suggested that, besides monocyte - derived macrophages, dendritic
cells, a distinct myeloid
lineage, also express PPARγ at high levels.
Currently, we are exploring
several environmental samples retrieved from allover the world - ranging from hydrothermal vents in Japan to hot springs in Yellowstone National Park and New Zealand — for the presence of novel archaeal (and bacterial)
lineages using cultivation - independent approaches, such as metagenomics and single
cell genomics.
Dr Véronique Azuara has worked for
several years in the field of developmental biology and genetics moving from lymphocyte development (PhD training at the Pasteur Institute — Paris) to epigenetic studies (post-doctoral training at the MRC / Clinical Sciences Centre — London) to explore how chromatin shut down contributes to
lineage restriction and maintenance of
cell fate identity through development.
Studying the epigenetic setting of germ
cells allows investigating
several crucial aspects of mammalian biology such as transposon control, genomic imprinting and early
lineage commitment.