Not exact matches
Gene technology encompasses
several techniques including marker - assisted breeding, RNAi and genetic
modification.
The researchers linked the excess weight and changes in metabolism to epigenetic
modifications that reduce expression of the
gene for adiponectin — a hormone that helps regulate
several metabolic processes, including glucose regulation.
When the researchers extended the analysis to a separate group of patients and mice that had been exposed to tobacco smoke, they narrowed down the epigenetic
modifications to
several sites located in four
genes that have been weakly linked to cancer before.
Several types of chemical
modifications of the five major histone protein families give rise to a complex «histone code» that signals the transcriptional machinery to turn
genes on or off.
We found that
genes within islands of differentiation were enriched for
several functional classes (Table S4), and most terms were related to transcription and epigenetic pathways (e.g. chromatin organization and
modification, regulation of transcription and translation, DNA binding).
We furthermore show that
several of these RNA
modifications have a dynamic response to environmental stress and that, in particular, changes in the tRNA wobble base
modification 5 - methoxycarbonylmethyl -2-thiouridine (mcm (5) s (2) U) lead to codon - biased
gene - expression changes in starved animals.