Sentences with phrase «several gene variants»

While those studies identified several gene variants that appeared to increase the risk of each disorder, none of the associations were strong enough to meet the strict standards of genome - wide significance.

After analyzing human DNA from several populations around the world and examining primate genomes dating back to the shared ancestor of both humans and chimpanzees, researchers reached a striking conclusion that several gene variants linked to schizophrenia were actually positively selected and remained largely unchanged over time, suggesting that there was some advantage to having them.

Genes also play a role in menopause, and two research teams have identified several gene variants associated with advancing or delaying menopause by as much as two years.

Not exact matches

They discovered that several genetic variants in the hunter - gatherers were linked to a gene associated with physical performance, which they hypothesise could be part of the physiological adaptation to cold.

While several studies in the intervening years have investigated whether particular genes were responsible for modifying HD onset, this is the first to employ genome - wide association (GWA) analysis, which scans an individual's whole genome to identify chromosomal regions containing variants that are associated with the disease traits that are being studied.

In several groups of people, a gene variant allowing the lactase, the enzyme breaking down the sugar in milk, to persist into adulthood became common about 5000 to 7000 years ago, when humans were herding cattle — as evidenced by this rock painting of domestic cattle in the Jebel Acacus region of the Sahara desert in Libya.

In all, the study included the data of more than 23,000 people to show that approximately 12 percent of a person's variation in delay discounting can be attributed to genetics — not a single gene, but numerous genetic variants that also influence several other psychiatric and behavioral traits.

Sex determining genes exist in several different variants, but close family members are likely to share the same variants.

He said: «Over the past several thousands of years, the deficiency gene seems to have been positively selected, and is mainly found in north Europe, as have gene variants for larger height and size generally.

The gene for MAO - A has several variants, some of which are associated with relatively higher and lower levels of enzyme activity.

So are several other gene variants.

Comparing the two sets of genes, the team discovered several immune - related gene variants that were rare among the living.

Several different variants are all uniquely associated with pigmentation near these genes, and variants in these genes have been associated with pigmentation in animals.

The other finding was of a variant near genes for several so - called semaphorins, proteins that guide developing nerve cells as they grow toward their final targets.

By focusing on several of these mutations and screening through guide RNA variants with different mismatch combinations, they were able to identify specific guide RNAs that stimulated Cas9 activity towards the mutated gene sequences but left the normal counterpart untouched.

Scientists have confirmed one gene variant and have identified several others that may be risk factors for late - onset Alzheimer's disease, the most common form of the disorder.

In these studies, sequence data from several thousands of individuals is compared to find disease - associated genes where cases have a higher load of genetic variants that are likely to disturb gene function, compared to the controls.

For instance, if several relatives suffer from depression, researchers can sort through their DNA hoping to find regions they all share — in higher proportions than would be expected given their relatedness — where a variant disease gene might lie.

the evolution of domesticated animals has been underway for so long that we can now see the evolution of gene variants, that is, genes in which several successive mutations gradually changed the function of the gene.

psq is a widely expressed gene that by alternative splicing gives rise to several protein variants that share a PSQ DNA - binding motif (Weber et al. 1995; Horowitz and Berg 1996; Lehmann et al. 1998).

In case several constructs or construct variants (Scenario A or B) need to be tested, the additional genes have to be supplied by the user.

And yet, even after you sequence the exomes of several family members (affected and unaffected) the causal variant or gene remains elusive.

Several genes influence a person's likelihood of developing fatty liver disease, but a recent study in Nature Genetics found that people with high - risk gene variants were much more likely to actually get the disease if they were obese than if they were normal weight.

Several different variants in the Bestrophin gene (BEST1 (alias VMD2)-RRB- have been identified as likely causal mutations for CMR in the dog.