Not exact matches
They hit pay dirt on chromosome 10, finding
such a
marker in a region with
several genes thought to affect heart function.
Of note, mouse neural stem cells (NSCs) were reprogrammed using only one (Oct4) or two factors (Oct4 and Klf4), due to the endogenously high expression of pluripotent genes,
such as Sox2 and c - Myc, as well as
several intermediate reprogramming
markers [14], [17], [18].
Several trials have demonstrated that the cardiomyocytes of rodents maintained on IER become more resilient to ischaemic injury induced by occlusion of the left coronary artery 18, 21, 29, which translated into improved long - term survival following
such injury in one study.21 In addition, within these studies, associations have been found between the cardiovascular improvements and
markers of oxidative stress 24, 30, inflammatory responses 18, 24, 29, 30 and increases in circulating levels of adiponectin.29 Collectively, these reported changes in biochemical and physiological cardiovascular risk factors would be expected to suppress atherosclerotic development and preserve cardiovascular health.
There are
several alternative explanations to this «lack» of anti-inflammatory effect (I'd have liked to see the concentrations of other inflammatory
markers such as CRP, directly linked to the risk of developing cardiovascular disease).
Second, we included some of the most well - studied moderators but excluded
several other potentially relevant child and family characteristics
such as children's executive functioning (e.g., Matthys et al. 2012) and biological
markers of children's differential susceptibility to environmental influences (e.g., Belsky et al. 2007).