Sentences with phrase «several new genes»

We will identify where the guideline strengthens or reaffirms the 2013 recommendations for patients with lung adenocarcinoma, as well recommendations for testing for several new genes.

The researchers also identified several new genes related to anxiety behavior in flies.

The scientists discovered several new genes which predispose low HDL - cholesterol levels.

Wang designed genetic screens that allowed her to find several new genes involved in engulfment.

The next decade may see several new gene - edited crops on the market, offering a range of traits that improve things like drought tolerance and offer higher yields.

Not exact matches

«Testing of new rice varieties that have the SPIKE gene is under way in multilocation trials across several developing countries in Asia, including Indonesia.

The researchers identified several reasons for this: The new gene constructs interfere with the plant's own gene for producing growth hormones, and the additional gene constructs were not, as intended, active solely in the kernels, but also in the leaves.

Now, new research has found several rare genetic mutations on the same gene that definitively connect the two.

In the new study, Duke University researchers overcame several of these obstacles by using a non-pathogenic carrier called adeno - associated virus, or AAV, to deliver the gene - editing system.

«Within the context of our emerging appreciation of polygenic risk, where gene variations are implicated in several disorders, the new findings point to only partial overlap in the risk mechanisms for these two forms of bipolar disorder,» said Dr. Krystal.

These deletions also may extend to neighboring genes, an event known as «collateral lethality,» which may create new options for development of therapies for several cancers.

The process, reported in Human Reproduction, utilizes DNA fingerprinting (an assessment of active genes in a given cell) to boost the success rate of IVF and lower the chances of risky multiple births by identifying which of several five - day - old embryos are most likely to result in pregnancy The new method, which will replace unproved alternatives such as choosing embryos based on their shape, is likely to up the success of women becoming pregnant and lower their chances of having multiple births.

The study found several genes that are associated with resistance to antibiotics, including new genes that might point to previously unknown mechanisms of drug resistance.

New research findings from Uppsala University and Uppsala Clinical Research Center show that smoking alters several genes that can be associated with health problems for smokers, such as increased risk for cancer and diabetes.

These new findings, along with other recent studies, suggest that the risk for congenital heart defects in Down syndrome can come from several genes and environmental factors, in addition to the substantial risk from the extra chromosome 21.

Despite this new direction for identifying targets for pharmaceutical interventions against RP, the researchers underscore that gene therapy still has great potential and possible benefits, and they are actively pursuing efforts with this approach for several forms of RP.

The three Ras genes found in humans — H - Ras, K - Ras and N - Ras — were among the first to be linked to cancer development, and a new study led by VCU Massey Cancer Center researcher Paul Dent, Ph.D., has shown the recently approved breast cancer drug neratinib can block the function of Ras as well as several other oncogenes through an unexpected process.

«We have already found several gene types that are dramatically expanded in the octopus relative to other vertebrates, and we think they play a critical role allowing a new level of neuronal complexity to be reached in invertebrates,» he said.

This work, published in the journal Molecular Cell, reveals a new role for each nucleus» several hundred pores, which constitute as many microscopic factories of gene transcription.

The predominant modern su1 allele was found in all of the older Mexican cobs, but the younger New Mexican cobs had several different alleles, suggesting that this gene was still undergoing selection when maize reached North America.

A single injection of a new treatment has reduced the activity of the gene responsible for Huntington's disease for several months in a trial in mice.

By tweaking the ingredients of the zinc finger in the new study they were able to extend its effects to several months, repressing the disease gene over that period without seeing any harmful side effects.

Within a month, using novel organic molecules as markers, he and Malcolm had bagged several dozen genes — a new record.

The new discoveries pertain to the way several parts of the machinery come together and work in concert to tamp down gene expression.

The company found several new disease genes, including mutations in one gene, ABCA7, that double the risk of developing Alzheimer's disease in people of European ancestry.

As a new generation of gene therapy clinical trials shows promise to cure or halt the progression of several rare diseases, the time has come to explore ways to pay for the cutting edge treatments, a pediatric hematologist - oncologist from Dana - Farber / Boston Children's Cancer and Blood Disorders Center argues in a commentary published by the journal Science.

Noting the potential of gene therapy to be a one - time treatment for rare and serious diseases that otherwise cost hundreds of thousands, if not millions, of dollars in chronic care over a lifetime, Stuart Orkin, MD, and co-author Philip Reilly, MD, JD, of Third Rock Ventures, seek to «catalyze the discussion» by suggesting several new models for valuing, pricing and developing gene therapy.

An independent study published last month looked at several autism genes and made a strong case for three of the new genes2.

The study identified several other potential colitis genes, he added, and this particular one's effect on the barrier cells» energy requirements suggests a new category of mutations with the potential to cause IBD.

In the new study, the researchers discovered that during the second trimester of human brain development, oRG cells express genes related to a fundamental signaling pathway called mTOR, defects in which have previously been implicated in autism and several other psychiatric disorders.

In 2006 Pfizer started early human testing on one of these new, targeted drugs called crizotinib (now sold as Xalkori), concentrating on a mutation of a gene called MET, implicated in several cancers, including esophageal and stomach cancer.

The convergence of several factors explains the trend: cheaper genetic sequencing technologies, the discovery of new oncogenes (genes that can cause a normal cell to become cancerous), a new generation of computers and bioinformatics that can analyze vast amounts of data, and a multibillion - dollar effort by researchers inside and outside the pharma industry to develop targeted drugs and companion diagnostics for cancer.

Both of the new studies found that copy number events involving either duplication or deletion of the 25 to 30 chromosome - 16 genes — several of which are known to play a role in the developing brain — appear to cause autism.

New work uncovers several genes that might contribute to this creature's powers of perseverance.

The new catalog could help disease gene hunters in several ways.

The researchers propose that the rapid evolution and wholesale remodeling of the Y chromosome in both species have been caused by several mechanisms, including the competitive advantage gained by developing new genes for sperm production.

The three labs together identified several hundred human genes that influenza hijacks for its own benefit, but in most cases the groups each hit on different ones: Only about 30 genes overlap, an outcome that's «very surprising,» says Peter Palese, a virologist at Mount Sinai School of Medicine in New York City, who co-authored the paper with Chanda.

Jeffrey Hall and Michael Rosbash of Brandeis University in Waltham, Massachusetts, and Michael Young of The Rockefeller University in New York City share the prize equally for their work on how several genes work together to control the basic circadian clock, encoding proteins that build up during the night and are broken down during the day.

'' [Type 1 diabetes] is clearly is one of these complex genetic disorders,» involving mutations in several genes acting in concert to predispose someone to the condition, says Hakon Hakonarson, director of The Children's Hospital of Philadelphia's Center for Applied Genomics and lead author of the new study, published this week in the online edition of Nature.

If the beetle does evolve to resist an RNA molecule, he says, geneticists could easily launch a new assault: just «slide the sequence over» by a few letters or target several genes at once.

In the course of this work, he has pioneered several new approaches in the fruit fly that have had important implications for mammalian neurobiology, including: the demonstration that the fruit fly has a sleep - like behavior similar to that of mammals, studies of physiological and behavioral consequences of mutations in a neurotransmitter system affecting one of the brain's principal chemical signals, studies making highly localized genetic alterations in the nervous system to alter behavior, and molecular identification of genes causing naturally occurring variation in behavior.

For several decades, much attention has been placed on gene duplication as a source of new gene functions.

In the second study, a team led by Shahin Rafii at Weill Cornell Medicine in New York City used adult mouse cells as their starting material, and then guided them through several steps — including exposure to some of the same gene - activating proteins — to create mature blood stem cells in a petri dish.

Several agents could be placed on or in the eye, including long - lasting drugs that lower eye pressure, or modified virus particles that put new genes inside the eye cells to slow glaucoma damage.

Chemical controls are costly and potentially harmful to human and environmental health, so protecting crops like wheat with inherent resistance is the smart alternative, but resistance must be genetically complex, combining several genes, to withstand new mutations of the pathogen over time.

The lab focuses on clarifying the mechanisms of brain plasticity, gene expression, and responses of cellular elements to different psychotropic drugs, and have identified several novel brain sites and pathways that constitute attractive targets for new drug development.

McMaster University Scientists have published 2 studies identifying which gene is responsible for causing brain development disorders when several genes are deleted in an individual's genome, providing a path forward for developing new therapies.

He has made several important contributions in this area including identifying a new strain of CHIKV virus, identification of host cellular targets of HIV accessory genes, new novel DNA vaccine approaches for HIV, CHIKV, RSV, Dengue, MERS and Zika among others.

Several ongoing projects include the identification of newly discovered gene rearrangements in rare and refractory (unresponsive or resistant to therapy) tumors from patients evaluated at the Rutgers Cancer Institute of New Jersey.

New coding genes can arise in genomes through several processes, including gene duplication, gene fusion, de novo formation from non-coding DNA, or lateral gene transfer (LGT) from another species.