Sentences with phrase «several signaling pathways»

Finally, we identified several signaling pathways which may mediate this phosphorylation and act in combination to regulate Oct4 transcriptional activity and protein stability.

[42 - 46] KIT, a type III transmembrane receptor tyrosine kinase that sits upstream of NRAS and BRAF, feeds into several signaling pathways, including both the RAS / RAF / MEK / ERK cascade and the PI3K / Akt / mTOR pathway.

Not exact matches

Bowen's lab studied several sigma receptor areas, including signal - transduction pathways, novel binding elements (both agonists and antagonists), and clinical applications.

Several target molecules have also been identified in intracellular signalling pathways and in cell survival proteins.

They found that these genetic differences were tied to several important developmental and cell signaling pathways.

Several years ago, researchers found that 80 percent of patients with uveal melanoma had mutations to GNAQ or GNA11, genes that activate signals in the mitogen - activated protein kinase (MAPK) pathway.

Over several years, Dr. Stewart and colleagues unraveled genes and signaling pathways that drive multiplication (proliferation) of beta cells, and then confirmed proposed mechanisms with gene therapy.

His lab studies a particular signaling pathway, the RAS / RAF / MEK / ERK pathway, which regulates cell growth and survival in several cancers.

In the new study, the researchers discovered that during the second trimester of human brain development, oRG cells express genes related to a fundamental signaling pathway called mTOR, defects in which have previously been implicated in autism and several other psychiatric disorders.

B cell signaling pathways are the current targets of several therapies used to treat B cell malignancies such as CLL.

«We call Hsp90 inhibitors «network drugs» because they tackle several of the signals that are hijacked in cancer all at once, across a network rather than just a single signalling pathway.

We are particularly interested in how several molecular signalling pathways control the size to which the worm grows (about 1 mm long).

Anticancer activities of several anthelminthics attracted considerable interest, especially their capacity to target signal transduction pathways of CSCs / TICs of several tumor types.

Studies have shown that exposure of tumor cells to therapeutic doses of radiation activates cell survival signaling pathways such as EGFR - RAS [2 - 5] and its downstream molecules such as ERK1 / 2, PI3K - AKT, JNK, etc. apart from several other signaling molecules [4, 6, 7].

The accumulation of calcium can then regulate the contraction of muscles, trigger the release of neurotransmitters or hormones, modulate intracellular signaling pathways, and impact several other calcium - dependent cellular functions.

We have identified several molecular targets such as Bcl - xL, Bcl - 2, and survivin, along with upstream signaling intermediates such as PI -3-kinase, Akt, and the canonical and non-canonical NF - κB pathways that control the activities of OX40.

Regulation of IL - 22 production by ILC3s is controlled through several well - described signaling pathways.

Western blot analysis showed that phosphoinositide - dependent protein kinase 1, the upstream kinase that phosphorylates Akt, and several phosphatases (phosphatase and tensin homolog deleted on chromosome 10, protein phosphatase 1, and protein phosphatase 2A), known as negative regulators of the PI3K / Akt signaling pathway, were unchanged upon VPA treatment (Supplemental Fig. 4E), indicating that VPA might act on Akt directly.

Several IFN signaling pathway — related key regulators, including STAT1, STAT2, IRF - 1, and IRF - 9, were transfected individually or in combination into STAT1 - deficient U3A cells, together with a luciferase reporter gene containing RIG - G promoter.

Lung morphogenesis is a well orchestrated, tightly regulated process through several molecular pathways, including TGF - β / bone morphogenetic protein (BMP) signaling.

The differentially expressed genes were significantly associated with several immunological pathways, including the IL - 4, IL - 6, IL - 17 and glucocorticoid receptor signalling pathways.