These demonstrated that both primary CD4 and CD8 T cell responses and development of memory to protein
antigen in adjuvants (e.g. CFA, alum), or to
several viruses, or to a range of
tumors are strongly controlled by OX40.
In the experiments described in the paper, the MGH team confirmed that their mesothelin - targeting fusion protein binds to mesothelin on either ovarian cancer or mesothelioma cells, activates dendritic cells, and enhances the cells» processing and presentation of
several different
tumor antigens, inducing a number of T - cell - based immune responses.