Jak3 - deficient mice had profound reductions in thymocytes and severe B cell and T cell lymphopenia similar to
severe combined immunodeficiency disease (SCID), and the residual T cells and B cells were functionally deficient.
(a) Representative images of lungs from tumor - bearing non-obese diabetic /
severe combined immunodeficiency disease (NOD / SCID) mice are shown (n = 6).
(a) Growth curves of primary tumors in non-obese diabetic /
severe combined immunodeficiency disease (NOD / SCID) mice injected with 5 × 105 or 5 × 104 MDA - MB 231 and MDA - MB 231 F3 cells.
By means of a non-obese diabetic /
severe combined immunodeficiency disease (NOD / SCID) xenotransplant assay in combination with specific cell surface markers (CD44 + CD24 - / low), CSCs were enriched from metastatic and primary breast tumors and were shown to have the ability to reestablish tumor heterogeneity after transplantation [1].