While severe zinc deficiency can cause a variety of extreme symptoms, researchers estimate that a large percentage of the world's population may have a mild zinc deficiency.
This study demonstrated that even brief periods
of severe zinc deficiency can lead to measureable changes in sperm composition and quantity.
Severe zinc deficiency depresses immune function [48], and even mild to moderate degrees of zinc deficiency can impair macrophage and neutrophil functions, natural killer cell activity, and complement activity [49].
While severe zinc deficiency is not common in the developed world, there is increasing evidence that low - level zinc deficiency may be prevalent and may affect skin, eye, hair and immune health.
The results are published in the current issue of Nature Communications and provide a roadmap for potential target sites for people suffering from acrodermitis enteropathica, a rare but lethal genetic disorder leading to
severe zinc deficiency, and pancreatic cancer where ZIP4 is abnormally overexpressed.
This indicates
a severe zinc deficiency.