Sentences with phrase «severing axons»

Severing axons, or axotomy, is a simple way to study the molecular basis of neurodegeneration as it leads to the activation of explosive axonal degeneration.

In the central nervous system, severing axons causes the entire neuron to die quickly, but why they die has been a mystery.

The researchers found severed axons in regions with inflammation characteristic of the disease — in several cases, more than 10,000 times as many cut axons as in brain tissue from non-MS corpses.

A high density of severed axons could explain the irreversible nature of progressive multiple sclerosis, he says.

«This is the first time a molecule involved in apoptosis has been found to have the ability to repair severed axons, and we believe it has great therapeutic potential.»

In mice without Phr1, they found that about 75 percent of the severed axons remained at five days, with a quarter persisting at least 10 days after being cut.

In the normal mice, a severed axon degenerated entirely after two days.

After the suture was removed and blood flow was restored, they were given additional surgery to sever the axons of the corticospinal tract.

When pathologists perform autopsies on people with diffuse axonal injury, they see severed axons with swollen tips, just like what Smith sees in his experiments.

Scientists do know that a severed axon will cause a neuron to quickly lose some of its incoming connections from other neurons.

Not exact matches

And in transgenic pups whose optic nerves were surgically severed 4 days after birth, retinal axons grew around the gap, finding their way to the proper target areas in the brain.

And once an axon is severed, «the function of that neural cell is lost forever,» says the Cleveland Clinic's Bruce Trapp.

The injuries crush and sever the long axons of spinal cord nerve cells, blocking communication between the brain and the body and resulting in paralysis below the injury.

Sheng and his research fellow Bing Zhou, the first author of the study, initially found that when mature mouse axons are severed, nearby mitochondria are damaged and become unable to provide sufficient ATP to support injured nerve regeneration.

They observed that those reactive astrocytes formed quickly after axons were severed, but that neutralizing TNF - alpha, IL -1-alpha and C1q with antibodies to these three substances prevented A1 formation and RGC death in the animals.

In another experiment, the researchers severed rodents» optic nerves — an act ordinarily lethal to RGCs, whose outgoing fibers, called axons, constitute the optic nerve.

This recovery progressed in those mice whose axons were not severed.

When it is experimentally prevented (either by severing the projecting axons, by treating them with the drug vinblastine, which blocks axonal transport, or by administering 6 - hydroxydopamine, which destroys the nerve endings), the innervating sympathetic neurons in the ganglion die off.

This injury severs descending, supraspinal axons and causes chronic deficits in both fore - and hind - limb motor function [32], which can be detected by the grid - walk behavioral test [33].

Searching the entire genome, a Yale research team has identified a gene that when eliminated can spur regeneration of axons in nerve cells severed by spinal cord injury.