Nanorod structures aren't new, but the technique used by Lin's lab produces nanorods of uniform sizes — such as barium titanate and iron oxide, which have not yet been demonstrated via wet - chemistry approaches in the literature — and highly - uniform core -
shell nanorods made by combining two dissimilar materials.
The gold - iron oxide core -
shell nanorods may be useful in cancer therapy, with MRI imaging enabled by the iron oxide shell, and local heating created by the photothermal effect on the gold nanorod core killing cancer cells.
Not exact matches
«Once in solution, the TEOS begins to form a silica
shell on the
nanorods.
With thin
shells, the change in size of the
nanorods is minimal, and the gold
nanorods can still pack into dense assemblies.
One way to help gold
nanorods retain their shape during photothermal heating is to coat them with silica
shells, which confine the
nanorods to their original shape but allow light to pass through.
Gold
nanorods are being investigated for use in a wide variety of biomedical applications, and this advance paves the way for more stable gold
nanorods and for chemically functionalizing the surface of the
shells.
«The silica
shells offer multiple benefits — and our modified approach to coating gold
nanorods with silica
shells has two distinct advantages,» Tracy says.
On the other hand, thicker
shells can act as buffers, preventing
nanorods from bunching closely together and shielding them from their environment.
For the future, Lin envisions more complex nanocrystals with multifunctional
shells and additional shapes, including
nanorods and so - called «Janus» nanoparticles that are composed of biphasic geometry of two dissimilar materials.
This work was supported by the National Institute of Health, grants 1R21CA133641 and R01GM094816 and Hamill Innovation Award to D.O.L., P01CA098912 to M.C.F.C. Authors thank Professor S. Link (Rice University) for providing gold
nanorods, Professor R.A. Drezek for providing silica - gold
shells and the members of the Carson laboratory, especially Drs. Brian Danysh and Pam Constantinou, for many helpful discussions.