Sentences with phrase «shift over the cycle»

Researchers have also known about and documented periodic shifts over cycles of 21,000 years, 41,000 years and 100,000 years, all of them also driven by astronomical change.

Not exact matches

These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

I emphasize the phrase «from current price levels,» as a significant retreat in valuations is likely to dramatically shift this profile, as it has over the completion of every market cycle in history.

I have no question that these conditions will emerge over the completion of the current market cycle, and - despite the truncated bullish shift and awkward transition that followed my 2009 stress - testing decision - there is not a single market cycle in 30 years as a professional investor where those same conditions did not provoke me to adopt a constructive outlook.

Additionally, the U.S. economy has dramatically changed over the past several years, with structural factors (largely the result of technological innovation and shifting demographic trends) influencing it in a manner that makes comparisons to past rate hiking cycles less relevant.

If market internals improve, we'll take a signal that investors have shifted back to risk - seeking, and that would ease our near - term concerns, but wouldn't materially change our expectations for a market loss on the order of 50 % or more over the completion of the current cycle.

In addition to the long - term growth trend, there have been structural shifts in the semiconductor industry over the past few years that should make cycles less volatile going forward.

But a serious analysis of survey data over time provides little evidence that this fall's election cycle substantially shifted public opinion in favor of legal abortion.

Over the past ninety years or so, the American debate about the national interest and the national purpose» the debate about morality and foreign policy» has careened through at least ten cycles, resulting in numerous, and sometimes jarring, shifts in the nation's approach to the world.

[Spin Cycle] Capitalizing Callaghan Shifts Into Overdrive [Newsday] Hevesi's Security Detail Twice As Large As Spitzer's [AP] Alan Overdrive [NYP] Aide's «Squad» Car Ride [NYDN] Hevesi Smooches Up Pol Pal [NYP] Thanks to Hevesi, Democrats Face Political Tightrope [NYS] Pataki Picks Ex-Prosecutor to Weigh In on Hevesi Case [NYT] Hevesi: I'd Quit Over Ax [NYP]

As the major areas of contention become clear, some remain from recent years, while others are new, and questions loom over the city budget cycle due to uncertainty in Washington, D.C., state funding shifts being proposed by Gov. Andrew Cuomo, and a slowing city economy.

Fluctuations at the core subtly shift the planet's rotation over a six - year cycle.

Processes that have historically altered the face of the planet, like cycles in the Earth's orbit around the Sun or shifts in continental tectonic plates, occur over tens of thousands to millions of years.

The sun's activity shifts over the course of its 11 - year cycle, with sun spot numbers, radiation levels, and ejected material changing over time.

In proper proportion, these hormones are like the two sides of a seesaw, shifting rhythmically back and forth over the course of the menstrual cycle.

Again, it's still early in the life cycle of both tablets and e-readers, and so we're going to see a lot of shifts over time as more groups find utility in these products.

It is rough for anyone relying on ratings during the bust of the cycle, because the philosophy shifts from «ratings are made over a full credit cycle» to «ratings should last until lunchtime, maybe, uh, look the stock price is down 5 %, post a downgrade.»

Given how much yelling takes place on the Internet, talk radio, and elsewhere over short - term cool and hot spells in relation to global warming, I wanted to find out whether anyone had generated a decent decades - long graph of global temperature trends accounting for, and erasing, the short - term up - and - down flickers from the cyclical shift in the tropical Pacific Ocean known as the El Niño — Southern Oscillation, or ENSO, cycle.

SCL» & SCL» -LRB--1 / 4 cycle shift from SCL») do not have stationary periods over the 1749 + sunspot record, but they've recently hit ~ 60 years for 2 consecutive cycles.

This analysis is probably floored, and the economics probably a little better because power prices will rise over time and batteries partially cycle from moment to moment and so can actually shift more power but this is of little economic benefit when net metering is available (giving near retail rates to exported power) and so the fact remains batteries are still uneconomic by a factor of 300 % even with the SGIP.

Those who invoke the solar cycle, to which there is no global temperature correlation even if one allows for phase shifts, or who cite possible increases in solar flux, of which observations show none over this warming epoch, are especially off the mark.

So there's been NO ocean cycle influence whatsoever over this period, the Great Pacific Climate Shift of 1976/77 had no impact at all on global temperatures.

The predominance of landmasses in the northern hemisphere causes glaciations to predominate over interglacials by about 9 to 1 with a full cycle every 100, 000 years helped along by the orbital changes of the Milankovitch cycles that affect the pattern of insolation on those shifting cloud masses.

Regonda et al 2005: «Seasonal Cycle Shifts in Hydroclimatology over the Western United States» http://civil.colorado.edu/~balajir/my-papers/regonda-etal-jclim.pdf

While in - house growth has cycled up and down over the years as is typical of most industries» pendulum swings between insourcing and outsourcing, our most recent growth surge (over the last 7 - 10 years) was uncommonly large and fast - paced, with the result that some law departments suddenly find themselves too expensive for the work they currently perform (based on the market value of the work) and others may find themselves too ungainly to be agile in responding to market service offerings (where they previously could have insourced or outsourced work based on emerging and shifting needs).

The position of the Arctic Circle is not fixed and, over the course of the slow and cyclical 40,000 year shifting of the Earth's axial tilt, it fluctuates by a margin of two degrees — at the point of the cycle we're now in, it is drifting northwards at a rate of 49 feet (15 meters) per year.

REIT analyst Steve Manaker says he has seen REITs shifting focus among management teams from short - term goals to sustained growth over market cycles.