Sentences with phrase «shorter telomere»

Stress exposure in intrauterine life is associated with shorter telomere length in young adulthood

Shorter telomere length is associated with increased risk of premature death and chronic disease such as diabetes, dementia, stroke and heart disease.

«We found that women who sat longer did not have shorter telomere length if they exercised for at least 30 minutes a day, the national recommended guideline,» says Shadyab.

Scientists suspect that each new generation gets a shorter telomere cap until finally the cells can divide no more.

The more chronically stressed we are, the shorter our telomeres become.

In people with recurrent depressions, a correlation could also be found between low cortisol levels and short telomeres.

These caps shorten every time a cell divides, and short telomeres are a sign that the body's cells are wearing out and ageing.

This is interesting since short telomeres are considered an indication of premature aging and a high accumulation of stress.

Very short telomeres can lead to trouble, such as chromosomes breaking apart and fusing to one another.

Telomere length does seem to be linked to life span; one key study in The Lancet found that otherwise - normal people over 60 who started out the study with short telomeres were more likely to die over the next 17 years than those with long telomeres.

Greider and Hackett wondered whether short telomeres might render chromosomes vulnerable to a type of enzyme called an exonuclease, which degrades DNA.

The team suggests a potential explanation for this observation is that long telomeres enable more rounds of cell division than short telomeres, which could allow cells to live longer and have more opportunities to accumulate carcinogenic mutations.

In another clue that cancer cells persist because they maintain their telomeres, those cells that started out with longer telomeres in the experiment lived longer than those with shorter telomeres.

Some cloned mammals, including Dolly, have shorter telomeres than other animals of the same age.

Mariela Jaskelioff and her colleagues at the Dana Farber Cancer Institute in Boston, Massachusetts, engineered mice with short telomeres and inactive telomerase to see what would happen when they turned the enzyme back on.

Individuals carrying the variant had shorter telomeres, stretches of DNA at the ends of chromosomes that protect them from daily wear — and also aging

He suspects that the telomerase levels are sufficient to lengthen the shortest telomeres, but not keep them all long and healthy.

Great tits raised in an urban environment have shorter telomeres — protective caps at the ends of chromosomes — than those raised in rural environments, researchers find.

Babies born to obese mothers have shorter telomeres - equivalent to up to 10 years» extra ageing - which may put them at risk of diabetes and heart disease

The reason, he said, is that if a TERT promoter mutation arises to push a precancerous lesion — the mole or nevus — toward a melanoma, the chances are greater in someone with short telomeres that the cell will die before it up - regulates telomerase and immortalizes the cells.

If cells fail to turn up telomerase, they also fail to immortalize, and eventually die from short telomeres because chromosomes stick together and then shatter when the cell divides.

The finding also resolves another recent counterintuitive finding: that people with shorter telomeres are more resistant to melanoma.

They might do just fine, but if there's something else going on combined with the shorter telomeres, that might be enough to kill them.

Discover: So the shorter the telomeres, the more likely it is you'll be stricken with diseases and that you'll age faster?

Blackburn and UCSF psychologist Elissa Epel's work found that the most stressed - out women had shorter telomeres that translated into an extra decade or so of aging compared with their matched controls — showing that external stressors can throw a monkey wrench into the cell's molecular mechanics.

Pessimism correlates with shorter telomeres.

But some groups may have shorter telomeres for reasons other than aging.

Shorter telomeres are linked to higher risks for heart disease, obesity, cognitive decline, diabetes, mental illness and poor health outcomes in adulthood.

Dr. Anna Z. Pollack, lead author of the study, pointed out, «with cross-sectional data, we can't tell if having children is related to shortening of telomeres or merely whether women who have children start out with shorter telomeres.»

According to the researchers, the induced stress that the urban great tits are experiencing is what results in shorter telomeres and thereby increases their risk of dying young.

There are types of aplastic anemia that are not associated with short telomeres.

Surprisingly, people who are infected with a latent virus, that is, an asymptomatic virus, have shorter telomeres.

Short telomeres.

Research results from Lund University in Sweden show that urban great tits have shorter telomeres than others of their own species living in rural areas.

The length of the telomeres can be described as a kind of age biomarker — short telomeres mean short life expectancy.

A common trait in aplastic anemia, regardless of whether it is inherited or acquired, is the presence of short telomeres.

«We provide proof - of - concept that the telomerase based treatment -LRB-...) has a therapeutic effect on the type of aplastic anemia caused by short telomeres,» the authors state in an article in the journal Blood, with Christian Bär among them as the first author, as well as Juan Manuel Povedano.

The variant lies near a gene called telomerase RNA component, or TERC, and earlier studies in animals have shown that low TERC expression is associated with shorter telomeres, and faster biological aging.

The researchers found that individuals carrying a particular genetic variant had shorter telomeres — meaning less padding for those fragile genes.

But it's unknown whether shorter telomeres make their carriers physically appear older than they really are.

Studies comparing telomere lengths in individuals against the population as a whole suggest that shorter telomeres are linked with ill health and a shorter life.

Previous studies have suggested that shorter telomeres are linked to heart disease, dementia and cancer.

There also is evidence the offspring of older parents have shorter telomeres, but it is not clear whether this is due to the offspring inheriting shorter telomeres or if their telomere loss during pre - or post-natal growth is higher.

They found that women with the lowest number of eggs also had the shortest telomeres — the chromosome caps that wear away as cells age — in their white blood cells.

Stress for cells usually means severe DNA damage that could produce cancer, critically short telomeres or other molecular catastrophes that trigger shutdown mode.

People who go on to have heart attacks have much shorter telomeres than those who remain healthy, a major new study has shown.

It means that ADHA children, who already have shorten telomeres, will generate an offspring with shorter telomeres at birth.

Fathers and mothers with shorter telomeres transmit this characteristic to their children.

Brazilian scientists from the D'Or Institute of Research and Education (IDOR) and the Federal University of Minas Gerais (UFMG) found that ADHD kids and their mothers are more likely to have shorter telomeres, a hallmark of cellular aging, which is associated with increased risk for chronic diseases and conditions like diabetes, obesity and cancer.

The shorter the telomeres are, shorter is the biological «life expectancy» of one.