This experiment was conducted to verify the findings in the initial experiment of a
hypersensitivity immunopathologic - like
reaction after SARS - CoV challenge of vaccinated animals, to determine if a higher dosage of the S protein vaccine (SV) would suppress infection and still exhibit a similar
reaction, and whether the original β propiolactone inactivated whole virus vaccine (BPV) that had
shown an immunopathologic - like
reaction after challenge of vaccinated ferrets and nonhuman primates exhibited a similar immunopathologic
reaction in the mouse model [13], [14].