Sentences with phrase «showed altered gene»

The male offspring of mothers fed the high - fat diet showed altered gene expression in the hippocampus which persisted through adulthood.

These features were related to a modified gene expression pattern in adult male testes, showing an altered gene expression in genes involved in DNA repair and apoptosis that was confirmed by TUNEL assay.

Not exact matches

When normal and gene - altered mice got the high - fat diet along with varying levels of doxycycline, to induce GLP1 release, the normal mice grew fat and mice expressing GLP1 showed less weight gain.

«My team at Nationwide Children's has worked with commitment and dedication to develop a therapy that may subsequently be shown through future clinical trials to potentially alter the course of this unforgiving condition and provide a therapeutic option for the families and infants with SMA1,» says Jerry Mendell, MD, principal investigator in the Center for Gene Therapy at Nationwide Children's.

DNA extracted from the bones of an extinct bison shows that the environment influenced the way the animal's genes worked without altering the genetic code.

The work also shows we can alter development by changing the way genes are programmed, sidestepping the need for gene therapy.

In their study, the researchers showed that already at the age of six weeks in the mice with a rapid weight gain, the DPP4 gene was less methylated at four specific loci, i.e. epigenetically altered, compared to the other mice.

New research findings from Uppsala University and Uppsala Clinical Research Center show that smoking alters several genes that can be associated with health problems for smokers, such as increased risk for cancer and diabetes.

«Margery's experiments showed that the NS1 protein can alter expression of Hedgehog target genes on its own, without other viral proteins,» said Bier, professor and newly named holder of the Tata Chancellor's Endowed Professorship in Cell and Developmental Biology.

New research has found that the pharmaceuticals, which are frequently showing up in U.S. streams, can alter genes responsible for building fish brains and controlling their behavior

Interestingly, this study shows that altered dopamine levels can modify gene activity through epigenetic mechanisms despite the absence of genetic mutations of the DNA.»

In addition, they showed for the first time that these genes are often the same as those that are altered in breast tumours - when a tumour develops, the DNA within the cancer cells themselves mutates.

«We have shown that the synthesis of nitric oxide (NO), known to regulate gut motility functions and NRF2, a transcriptional factor known to regulate several antioxidant genes, mediated Phase II protein expression have been altered in colon specimens of polybacterialinfected ApoE - / - mice,» said Miriam Walker.

Scientists have shown that this voltage change can trigger a cascade of biochemical reactions that relay messages to the cell nucleus, changing gene activity and altering cell growth and differentiation.

More analysis showed that altering Cdk5 activity changed the level of several groups of genes that were also affected by aging, including those that control immunity, energy, and antioxidant activity.

After exploiting a technology that allowed them to activate each of nearly 16,000 genes individually in human melanoma cell lines containing mutant BRAF, the authors then treated the panel of cells with the drugs and monitored which cells showed altered drug sensitivity.

Researchers at The Rockefeller University have shown that a new technique using RNA interference is able to find genes that cause epidermal tumor growth in months rather than the decades it may take using traditional methods employing specially bred, genetically altered mice.

A video filmed at the McGovern Institute shows how dramatically the damaged SHANK3 gene can alter an animal's behavior.

Further research showed that the WWOX gene plays a role in the altered metabolism of cancer cells which are known to use glucose differently to normal cells.

The researchers showed these relationships between ecRNA production and gene activity in neurons included genes whose expression is altered by neuronal activity and genes implicated in developmental and neurodegenerative disorders.

Hill showed a single - nucleotide polymorphism — placed in the genome where a single nucleotide is altered — in this gene is «strongly associated» with elite sprint racing performance.

Changes in DNA methylation in brain cells has been an extremely active research area since these epigenetic changes were shown to alter the expression of genes needed to form and maintain long - term memories.

Of 17 regulatory variants identified in the two genes with regulatory variant burden, we show that at least six alter transcription factor - DNA binding in human neuroblastoma cells.

A single altered gene explains the black wings (left), new data show.

The researchers also showed just how flexible their LITE system could be by applying it to altering gene expression via epigenetics with the addition of histone modifiers.

The new data — from animals and human cells — show that the vapors released by e-cigarettes can alter the activity of genes.

BPA and vinclozolin both altered a small group of genes, the data show.

A novel study from researchers at Karolinska Institutet shows that by using so called random sequence labels, working as barcodes for tracing genetically altered cells, during CRISPR / Cas9 gene knock - outs it is possible to generate more comprehensive data from a smaller number of cells.

Several mutations in BRCA1, for example, have been shown to alter that gene's splicing and increase cancer risk.

AAEM pointed to numerous animal studies that showed oxidative stress, altered structure and function of the liver, intestinal damage, disruption of the immune system, increased cell growth and hundreds of alterations in gene expressions.

It has been shown that the induction of an altered phenotype by a maternal protein restriction diet during pregnancy involves changes in DNA methylation and histone modifications in specific genes, including the glucocorticoid receptor (GR)(33 % lower; P < 0.001) and PPAR?

Beta - carotene has been shown to boost immunity, alter gene expression (which could potentially protect us against cancer and autoimmune disease), and even strengthen the intestinal lining to protect against infection.

Studies in animals have shown that changes in diet can alter the function of genes — known as epigenetic change.

Pyrosequencing of 16S rRNA genes and temporal temperature gradient electrophoresis (TTGE) profiles in the colonic digesta showed that rats fed RS had altered microbiota compositions due to blooms of Bacteroidetes and Actinobacteria.

Studies are showing that by watching what we eat and how we exercise that we can alter our genes and how they are expressed.

there is a documentary released by bbc» pedigree dogs exposed» it talks extensively of the over angulation of the modern day show german shepherd and international vets proclaimin that the over angulated hind and slopy posture is actually a hindrance in the natural movement of a four footed animal... the documentary has shown the movement of gsd in speciality championship show in probly canada and have claimed that the movement is altered from naturality and selective breeding solely due to cosmetic reason has led to the actual decline of the gene pool... and made the breed vulnerable to many ailments and health problems...

The researchers have shown that Synechococcus cyanobacteria — which use light to capture carbon dioxide from the air and produce energy for the marine food chain — contain specific genes which alters their pigmentation depending on the type of light in which they float.