Sentences with phrase «showed decreased expression»

We found that a gene signature consisting of 273 genes important for breast cancer bone metastasis showed decreased expression in ABL1 / ABL2 knockdown cells (Fig. 6B)(38).

It has been reported that human breast CSCs and normal human mammary stem / progenitor cells showed decreased expression of miR200c and other miR200 members and that restoring miR200c in breast CSCs inhibits their ability to expand clonally and form tumors in vivo [38].

Ward CE, Achenbach SE, Peterson ME: The inhibitory G protein, Gi2, shows decreased expression in adenomatous thyroid tissue from hyperthyroid cats.

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Results showed that BPA exposure permanently affected the uterus by decreasing regulation of gene expression.

They also showed that they could manipulate Klotho expression pharmacologically using the anti-diabetic drug rosiglitazone, which resulted in decreased levels of Wnt5A.

Remarkably, the relative expression levels of all marker genes were only slightly decreased when R206H ACVR1 and Q207D caACVR1 cultures were cotransfected with Noggin, whereas cells expressing the wild - type ACVR1 or empty viral vector showed clear downregulation of all analyzed marker genes for chondrogenesis.

While expression levels of all marker genes remained almost unchanged in wild - type ACVR1 cultures compared with the empty viral vector, the expression profile induced by caACVR1 Q207D displayed evidence of advanced chondrogenic differentiation as shown by decreased levels of the early differentiation stage marker collagen type II together with enhanced expression of the later - stage markers Ihh and collagen type X. Indian hedgehog has been shown previously to be induced by BMP signaling transmitted via the ACVR1 receptor (9).

Immunoblots showed almost complete inhibition of mTOR expression (as shown in Fig. 4B) that resulted in decreased cell proliferation as assessed by MTS assay (A).

In addition to miRNA200c and miR205, the cycling hypoxia - selected subpopulation showed decreased miR215 expression (Figure 6e).

As shown in Fig. 5A, decreased expression of DDX3 at the protein level was found in 73 % of HCC from 26 patients.

Cell cycle studies also showed that inhibition of mTOR function by using rapamycin or inhibition of mTOR expression by using mTOR - specific siRNA induced cell cycle arrest as shown by a dose - dependent decrease of cell cycle S phase (data not shown).

Expression levels of DDX3 mRNA in HCC samples as shown in (B) are classified into unchanged, decreased, and enhanced categories.

Our result showed that, among 26 cases with decreased DDX3 expression status, 20 cases (77 %) also showed simultaneous p21waf1 / cip1 down - regulation, and the correlation between the expression status of DDX3 and p21waf1 / cip1 was statistically significant (P = 0.039; Fig. 5C).

Transient transfection of ALCL cells with specific mTOR siRNA (20 μg) resulted in almost complete inhibition of mTOR protein expression at 48 hours (B) associated with a substantial decrease of p - p70S6K and p - rpS6 (not shown).

CLU is a confirmed AD gene from genome - wide association study, and encodes apolipoprotein J, which has been shown to chaperone re-entry of Aβ into the brain following export of the peptide from the brain into the blood.49 Interestingly, genes encoding two peptidases known to degrade Aβ were also decreased in expression in blood pre — post intervention as part of the vacation effect: MME (P = 0.00019) and ECE1 (P = 0.0037).

We also show that inhibition of mTOR with rapamycin, as well as silencing mTOR gene product expression using mTOR - specific small interfering RNA, decreased phosphorylation of mTOR signaling proteins and induced cell cycle arrest and apoptosis in ALK + ALCL cells.

Among these, SP1 showed a 6.1 % decreased expression in the adipose tissue of diabetic twins (P = 0.009).

RNASE2 shows a consistent decrease in expression across 13 tissues (Fig. 2d).

We found that 180 genes showed significantly decreased expression and 40 genes showed significantly increased expression in ABL1 / ABL2 knockdown cells (fig.

We showed that inactivation of the ABL kinases in breast cancer cells resulted in decreased expression of genes in the JAK / STAT and cytokine / cytokine receptor pathway signatures, which may be due to decreased STAT5A mRNA expression and reduced STAT5 phosphorylation in ABL1 / ABL2 - depleted breast cancer cells.

We show that miR - 30a - 5p binds the 3 ′ untranslated region of BDNF, and that overexpression of miR - 30a - 5p in the mPFC decreased BDNF expression.

Cells along the continuum show a progressively decreasing likelihood of self renewal as their expression of stem cell surface markers and pluripotency genes wanes.

We measured the expression of ALDH1 in cell lines following normoxic and hypoxic culture and, in support of the MFC and HFC data shown above, show increased ALDH1 - positive cell number in ER - α — positive lines and a contrasting decrease in ER - α — negative lines (Fig. 1D).

Furthermore, movement - independent ZENK expression in the forebrain of night - migratory birds performing magnetic orientation at night is confined to Cluster N [with the strongest activation in distinct subregions (the shell surrounding the DNH nucleus)-RSB-, as shown by the detailed quantification of ZENK expression within Cluster N performed in this study], and this expression massively decreased in corresponding brain areas of non-migratory songbirds and in all bird species during daytime [13].

We observed that SCGB1A1 expression is drastically reduced in current smokers but is expressed at similar levels in former and never smokers, and a previous study showed decreased serum SCGB1A1 level in smokers [44].

«Dark chocolate, a high source of polyphenols, and flavanols in particular, has lately received attention for its possible role in modulating obesity because of its potential effect on fat and carbohydrate metabolism, as well as on satiety... The research undertaken to date has shown promising results, with the possible implication of cocoa / dark chocolate in the modulation of obesity and body weight through several mechanisms including decreasing the expression of genes involved in fatty acid synthesis, reducing the digestion and absorption of fats and carbohydrates and increasing satiety.»

Three new independently conducted studies show that the increased BHB produced in a ketogenic diet improved the NAD + / NADH ratio which decreases expression of the pro-inflammatory NF - κB gene, resulting in:

Just like our mammalian peers, the typical human shows a decrease in lactase expression between the ages of two to five.

• Tang - kuei (Bai Zhi, Radix Angelicae Dahurica) Tang - kuei has been shown to modulate inflammation by decreasing leukocyte counts, neutrophil density, and interleukin - 6 (IL - 6) expression.

Studies showed that curcumin reduced joint swelling by modifying gene expression; inhibited inflammation by regulating NF - κB, a pro-inflammatory protein; and slowed down joint destruction by decreasing activity of osteoblasts, cells involved in bone breakdown.

The results showed that the combination of avocado / soybean unsaponifiables (ASU), glucosamine hydrochloride, and chondroitin sulfate is effective in equine cartilage cells (chondrocytes) and bone cells (osteoblasts) at inhibiting expression and decreasing production of mediators involved in joint cartilage breakdown.

In Study 1 (rural community), results of hierarchical linear modeling analyses showed that compared to the control condition (Head Start as usual), EBP produced greater increases in emotion knowledge and emotion regulation and greater decreases in children's negative emotion expressions, aggression, anxious / depressed behavior, and negative peer and adult interactions.