Sentences with phrase «showed high expression»

It is normally very sensitive to estrogen - targeting therapies because of high expression of the estrogen receptor protein, but rarely shows high expression of the HER2 protein.

However, two genes whose transcript levels are increased following a stressful growth arrest condition and DNA damage, Gadd45b (growth arrest and DNA damage - inducible 45b) and Ddit4 (DNA damage - inducible transcript 4), showed higher expression in the IVC males (Fig. 2B).

Not exact matches

The male offspring of mothers fed the high - fat diet showed altered gene expression in the hippocampus which persisted through adulthood.

«The 20 - year difference in expression of the gene abnormality shows the devastating consequences of recent environmental factors, such as eating high - glycaemic foods and a lack of exercise,» Froguel says.

Mesenchymal glioma stem cells show significantly higher radiation resistance and high expression of DNA - repair genes;

Remarkably, these brains showed higher levels of DCC expression — some 48 per cent higher when compared to control subjects.

This strategy grew out of previous work in the Goga's laboratory showing that MYC expression is disproportionately higher in triple - negative tumors than in tumors expressing hormone receptors and / or HER2.

«What caught my attention about autoimmunity and specifically lupus,» Anguera said, «was that there were genes on the X chromosome that were immunity related and that had been shown to have higher expression levels in lupus patients.»

This shift showed maximal expression when a high degree of pain was anticipated.

The researchers show that higher expression of the growth hormone IFG2, or insulin - like growth factor 2, is indicative of iPS cells initiating their conversion into hematopoietic cells.

The SPFES is a tool to measure pain levels based on facial expressions of sheep, and has been shown to recognise pain with high accuracy.

The study showed that TNBC patients whose tumours have high expression of RASAL2 tend to have a lower survival rate as compared to patients whose tumours have low levels of this gene.

Previous studies have shown a physiologic role for vitamin D in liver function, but «it was our discovery of high levels of vitamin D receptor (VDR) in the stellate cell that led us to consider it as a possible off switch for liver fibrosis,» says lead author Ning Ding, a research associate in the Gene Expression Laboratory.

(N) The results of quantitative RT - PCR showing the Acks expression in the MBs of intact and antennae - deprived workers under usual (33 °C) and high (46 °C) temperature.

Both experiments showed that the wild - type allele had greater DNA - binding capacity, and drove higher expression of the reporter gene.

The scientists also found that a protein known as CD29 acts as a cell - surface marker for precursor fat cells that can generate mature cells with high energy potential, as shown by their UCP1 expression.

As shown in Figure 1B, the PBAD (pBADTrfp) and Pxyls / PM (pXylsTrfp) promoter systems provided the highest RFP expression upon induction.

High mRNA expression levels of HNF4α and ASGPR1 are shown in the enhanced hiPS - HEP cells for an extended culture time and are comparable to levels in cryopreserved human primary hepatocytes (hphep cells) that have been grown for only a short time.

In these tests, StemFit not only delivered higher cell proliferation, but also showed characteristics such as homogeneity of gene expression compared with iPS cells cultured with four other media without any chromosomal abnormalities.

Expression was significantly higher in metastatic versus primary tissue cores (P < 0.05), as shown in Figure 2.

Results from studies with human cells showed highly reproducible expression levels, comparable with those determined by high - throughput RNA sequencing (RNA - seq).

Unpaired t tests showed that PD - L1 expression was significantly higher in metastatic versus primary tissue cores.

By boosting the expression of three genes involved in NPQ, they showed that NPQ turned off more quickly, and the efficiency of photosynthesis in the shade was higher.

[13,23] Studies show higher Toll - like receptor (TLR) 2 and TLR4 expression on oral Langerhans cells compared with Langerhans cells of the epidermis in steady state.

Interestingly, although larvae fed on either linseed oil or sucrose showed significantly higher expression of gbp1 and gbp2 when compared to those fed on agar, the effects on up - regulating gbp1 and gbp2 expression were significantly lower than that of casein.

The high expression levels of two genes (DNMT3A and DNMT3B) related to DNA methylation in our study is also consistent with a mouse study showing the elevated methylation in parthenotes compared to IVF / ICSI embryos [39].

Our results showed that hNSCs express 1.4 fold higher levels of SOX2, fourfold lower levels of c - MYC, and threefold lower levels of KLF4 relative to hESC expression levels.

Analogous to CCNA1 and EIF1AX discussed above, the higher expression of de novo methyltransferase, DNMT3B, in parthenotes may be due to the altered zygotic activation since DNMT3B expression has been shown to be originated from embryo [40].

Using these orthogonal measures of cellular pathway analysis, we confirmed that HPP - 4382, in contrast to bardoxolone, did not induce significant cellular stress at high doses as measured by HSPA6 expression and that the mechanism of HPP - 4382 activity does not appear dependent on NF - B as ICAM1 expression is not induced by HPP - 4382 (data not shown).

Two thirds of the animals showed equivalent expression values but the remaining five had increased expression levels up to ten fold higher than the mean expression across all animals (Figure S2C).

Also, gene expression analysis showed that ERBB2 expression correlates with outcome (higher expression = poor prognosis).

When the expression and phosphorylation patterns of HDM2 were examined, the results showed that HDM2 expression was induced by low doses of ActD (5 or 10 nM), and suppressed by high doses (> 10 nM) of ActD (Fig. 1A).

Epidermal stem cells from mouse tail skin visualized by wholemount 3D immunostaining: Left panel shows epidermal stem cells marked with BrDU (Label Retaining Cells); Middle and right panels Show expression of keratin - 15 and high expression of integrin alpha6, respectively.

Phenotypic characterizations reveal high levels of CD44, α2β1 integrin, and β - catenin expression in holoclones, whereas meroclones and paraclones show markedly reduced expression of these stem cell markers.

Of the two telomerase components analyzed, Tert (telomerase reverse transcriptase) expression did not show any differences between groups, but Terc (telomerase RNA component) transcription was significantly higher in the IVC testes (Fig. 2B).

Since there is a higher than 95 % chance that cluster assignments are accurate (Supplemental File S2), and our validation analysis shows that 90.7 % of the array expression patterns match the RNA analysis results using other techniques (e.g., Q - PCR), we estimate that more than 86 % of the genes in a cluster follow the corresponding average expression profile.

Within Cluster N, approximately 56 % of neurons show nuclear expression of ZENK protein with highest relative amounts of ZENK - positive nuclei found in the shell surrounding the DNH nucleus.

It is important to distinguish lineage specific gene expression shown here, which occurs at a high level and with a degree of specificity in the different population compartments, to the low level of genome wide transcription observed in ES cells by others [22], or with transcript initiation at many loci noted previously in ES cells [23].

The expression levels of relevant genes are shown in the diagrams by the standard red (high)-- green (low) color codes.

Using 5 % false discovery rate in ANOVA calculation in any of the 3 comparisons (CGR8 vs. E14TG2a vs. R1), there are 137 genes (0.9 % of the analyzed transcripts) that show a 2-fold difference or higher in expression levels among the three lines; 34 of these genes are > 2-fold higher or lower expressed in E14TG2a, 5 in CGR8 and 11 in R1 cells.

Inset shows higher resolution confocal images of photoreceptor cell nuclear layers (DAPI blue) and rhodopsin expression (red) in the dystrophic control (left inset) and dystrophic with iPS - RPE transplant (right inset) RCS rat.

For instance, Bace1 is abundant in neuronal - rich areas, such as the hippocampus, thalamus, and cortex, showing much higher expression than Bace2.

The authors showed that MELK expression is higher in high - grade breast cancers (Figure 2B), thus it is not clear whether MELK expression is higher in in BCC because there are more high - grade tumors in the BCC sub-types than the other 4 sub-types in the dataset used for the analysis.

«Dark chocolate, a high source of polyphenols, and flavanols in particular, has lately received attention for its possible role in modulating obesity because of its potential effect on fat and carbohydrate metabolism, as well as on satiety... The research undertaken to date has shown promising results, with the possible implication of cocoa / dark chocolate in the modulation of obesity and body weight through several mechanisms including decreasing the expression of genes involved in fatty acid synthesis, reducing the digestion and absorption of fats and carbohydrates and increasing satiety.»

The addition of sacha inchi oil slowed down glucose production in 16 (38.1 %) participants that showed a higher concentration of triglycerides before meals (fasting hypertriglyceridemia), whereas an improved expression of sirtuin - 1 (SIRT1), a gene responsible for regulating energy within the cells and coordinating cellular functions, was registered four hours after ingesting the meal enriched with sacha inchi oil, and linked to lowered levels of blood sugar measured at the same time.

Furthermore, high blood levels of insulin can act by increasing androgenous hormonal stimulation of the ovarian theca cells as well as potentiating gonadotropin - stimulated ovarian androgen steroidogenesis — although recent data has suggested that the insulin - induced increase in ovarian hormone secretion is not accompanied by increased steroid metabolism.74 Hyperinsulinaemia may also affect the central actions of androgen by impairing progesterone inhibition of the gonadotropin - releasing hormone pulse generator.75 Insulin has also been shown to increase expression of adrenal steroidogenic enzyme mRNA47 as well as adrenal responsiveness to adrenocorticotropic hormone.76

The results show that eHarmony couples scored significantly higher in regard to all four components of relationship quality measured by the Dyadic Adjustment Scale (DAS): consensus, satisfaction, affectional expression and cohesion.

Borrowing heavily from The Muppets (or even High School Musical), the overall plot — put on a show, save the home from closure — is predictable, but the performers are clearly having a good time; Michael Gambon is deliciously cruel as the show's controlling musical director, while unlike Marigold Hotel, Maggie gets more to do than simply look at people with a withering expression.

[12] Controlled, experimental studies exploring intrinsic motivation of college students has shown that nonverbal expressions of enthusiasm, such as demonstrative gesturing, dramatic movements which are varied, and emotional facial expressions, result in college students reporting higher levels of intrinsic motivation to learn.

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