In addition, many cancer cells express insulin receptors (IRs) and
show hyperactivation of the IGF1R - IR pathway.
Not exact matches
By studying human cancer cells and animal models of cancer in the lab, our researchers have
shown that loss of PTEN leads to high levels of PI (3,4) P2, which could result in
hyperactivation of AKT.
In line with our in vitro data, Pkn1 — / — mice
showed AKT
hyperactivation, elevated NeuroD2 levels, and reduced expression of PF - PC synaptic markers during stages of PF maturation in vivo.