Sentences with phrase «showed significant activity»

As a result, the unsubstituted analogue 117 showed significant activity even lacking the amine side chain.

Several of these derivatives showed significant activity.

Two of the young scientists» enzymes showed significant activity, leading them to be the first two authors on a Science paper.

The scientists found that when individuals completed a word puzzle, right before a moment of insight, a cluster of cells located in the superior temporal gyrus — in the right hemisphere of the brain — show significant activity.

Not exact matches

South African entrepreneur Errol has shown significant interest in expanding his reach in the online services marketplace with recent investment activity in real estate brands «Nested» and «Purple Bricks.»

Evidence shows that gojis exhibit significant hypoglycemic effects and insulin - sensitizing activity by increasing glucose responsiveness.

«If you look at it through the lens of a community approach, some of the good news — and I think it will show in time for us — is that we have a significant level of activity going on with our children,» Haberstro said.

As the state filings show, the only significant activity of the camp is retiring debt, which in large part must wait for the CFB's disbursement.

Professor Josep Tabernero, a member of the scientific committee for the EORTC - NCI - AACR Symposium and head of the medical oncology department at Vall d'Hebron University Hospital and director of the Vall d'Hebron Institute of Oncology, Barcelona, Spain, commented: «These are encouraging results, which show that galeterone has significant clinical activity in men with castration - resistant prostate cancer that fails to respond to other drugs.

Testing showed a significant increase in light - induced electrical activity from the eyes to the brain, indicating the rods and cones were operating as they should in the visual cycle.

Out of 58 hurricanes, 56 showed a significant correlation between lightning activity and wind speed, with peak winds arriving 30 hours after the lightning on average.

Not surprisingly, even healthy individuals show significant changes in brain wave activity during brief exposures to olfactory stimuli that are actually below the sensory threshold and not even consciously perceived.

«Our data shows both groups experienced significant improvements in pain measures by 26 weeks after surgery, including frequency of pain with activity,» commented lead author Martin Kroslak, MBBS, MSpMed, MSurg, from the Orthopaedic Research Institute in Sydney, Australia.

Igoshin said that when the researchers set out to find how sporulation decisions were timed to the cell cycle, several studies including prior work by team members, provided a significant clue: Under starvation conditions, the activity of the master regulator gene had been shown to spike once per cell cycle.

A mathematical model showed statistically significant seasonality and showed type A dissection and flu activity moving cyclically and generally in synchrony throughout the period.

They report that the test can detect significant drops in the metabolic activity levels of all three types of tumors within 72 hours when exposed to an effective drug whereas tumors that were resistant to a drug show no change.

Upon receiving two cycles of treatment with lenalidomide, the patient's breathlessness, fatigue, daily activity, and quality of life showed significant improvement, and her lung function testing demonstrated a remarkable increase in vital capacity.

Comprehensive analysis of satellite weather data shows that these are indeed regions where significant reductions in storm activity are detected during the rainy season.

While the team's research showed no significant difference in bacterial degradation of organic matter from cleared or forested watersheds, Canuel says it did show that «organic carbon in runoff from watersheds affected by human activity is less susceptible to solar degradation than that from forested watersheds.»

While all groups showed faster reaction times across sessions, the cognitive training group showed a significant increase in the association between reaction time and frontal lobe activity.

Findings of the study showed a significant correlation between increased tau and decreased metabolic activity in the brain, a clear sign of neurodegeneration.

Fifty - three of the brain cells showed significant changes in activity as the coils rotated, reacting to field strength and polarity.

That's the region showing significant gas ebb and flow — the activity that feeds star formation.

This species showed a significant decline in calling activity over four years, but in the fifth year the calling rate recovered to the original level (a dynamic which is common in many species, but often difficult to measure).

The measurements of brain activity taken before the musical training * showed no significant pattern of correlation.

When subsequent research showed that kdr alone was not operationally significant and activity of metabolic resistance genes appeared absent, pyrethroid IRS was reintroduced in 2012.

The fMRI scans showed significant neural activity that correlated to both craving and learning signals when participants smoked a nicotine cigarette and believed its nicotine content was genuine.

The analysis of five presidential voting outcomes, between 1960 and 2000, showed that southern counties with KKK activity in the 1960s had a statistically significant increase in Republican voting compared to counties with no established KKK chapter, even after controlling for a range of factors commonly understood as relating to voting preferences.

Evaluation of 66 patients with JDM, recruited from the UK JDM Cohort and Biomarker Study and actively treated with anti-TNF agents, showed significant improvements in muscle and skin involvement, as well as in overall disease activity.

«Scientists show how cancerous cells evade a potent targeted therapy: Significant antitumor activity was shown in cancers when this therapy was combined with an enzyme.»

About 16 % of the honeybee's 7500 genes showed a significant difference in activity between the two groups of bees.

This multimodal study shows significant correlation between increased tau and decreased metabolic activity in the brain — a clear sign of neurodegeneration — reveal researchers at the 2016 Annual Meeting of the Society of Nuclear Medicine and Molecular Imaging (SNMMI).

This result, however, might not necessarily mean that IAA plays no significant role in this defensive behavior because the Acks induction was not clearly observed in the ALs of the Japanese honeybee workers even after the seizure - induction, suggesting that Acks might not be applicable for detection of neural activity in the ALs (data not shown).

Dr. Parsons has been a strong contributor to departmental activities at The Scripps Research Institute and has shown significant leadership capabilities with his collegial interactions and many collaborations.

Animal studies using mouse models for human leukemia and lymphoma have shown Leukothera ® to possess significant anti-cancer activity.

Furthermore, niclosamide showed significant antitumor activity against a panel of cervical cancer cell lines via inhibition of mitochondrial respiration and the mammalian target of rapamycin (mTOR) signaling pathway [42].

Trace Levels of Copper in Carbon Materials Show Significant Electrochemical CO2 Reduction Activity Y. Lum, Y. Kwon, P. Lobaccaro, E. L. Clark, A. T. Bell, and J. W. Ager

Cultured pericytes abundantly expressed calpain1 (Fig. 2d) and showed a significant induction of calpain1 activity after stimulation with supernatants of Ang2 overexpressing HUVEC (Fig. 2e).

In comparison, the treated larvae showed significant hypo - activity.

For example, the replacement of an Arg residue with the epimeric N - methyl - D - arginine led to the identification of the cyclic pentapeptide - based CXCR4 antagonist FC122 (4) that shows a significant enhancement of CXCR4 antagonistic activity (Figure 5)[11, 66, 69, 70].

The study, published July 21, 2016, in Scientific Reports, also showed significant changes in the gut microbiome after antibiotic treatment, suggesting the composition and diversity of bacteria in the gut play an important role in regulating immune system activity that impacts progression of Alzheimer's disease.

Laminin cultured cells arrange themselves in lobule like structures, express MRP1 and MRP2 and are capable of biliary efflux and show significant effect on hepatocyte P450 enzyme metabolic activity.

Regular meditators had lower telomerase at baseline, but also showed a significant increase in peripheral blood mononuclear cell telomerase activity post treatment that was not observed in the other two groups.

1/17/2008 Rapid Effects of Intensive Therapy Seen in Brains of Patients with OCD In a study that may significantly advance the understanding of how cognitive - behavioral therapy affects the brain, researchers have shown that significant changes in activity in certain regions of the brain can be produced with as little as four week... More...

Using these orthogonal measures of cellular pathway analysis, we confirmed that HPP - 4382, in contrast to bardoxolone, did not induce significant cellular stress at high doses as measured by HSPA6 expression and that the mechanism of HPP - 4382 activity does not appear dependent on NF - B as ICAM1 expression is not induced by HPP - 4382 (data not shown).

«The antimicrobial effectiveness of eight of these peptides was evaluated against Pseudomonas aeruginosa and Staphylococcus aureus, with seven peptides exhibiting antimicrobial activity against both microbes, and one only showing significant potency against P. aeruginosa.»

No significant change was observed when these expression plasmids were transfected into U3A cells, except that C / EBPα had a potent repressive activity (data not shown).

However, ADCs that use derivatives of calicheamicin, which promotes double - stranded DNA breaks, such as GO and inotuzumab ozogamicin, 40,41 have limited activity in cells with high multidrug resistance protein activity, a phenotype found in a significant fraction of AML patients.42 Another ADC, SGN - CD123A, comprising an engineered form of the CD123 - targeting 7G3 antibody conjugated to a synthetic pyrrolobenzodiazepine dimer, which acts via DNA crosslinking, has entered clinical trials after showing robust activity in preclinical models of AML, including those with multidrug resistance.33

Furthermore, a paired t - test that compared brain activity of 4 - mm radii of the peak coordinate identified by the comparison between individuals with ASD at the placebo session and typically developing participants showed a significant increase of the originally - diminished brain activity in the oxytocin session compared with placebo [t (19) = 2.716, r2 = 0.28, P = 0.007, one - tailed](Supplementary Fig. 1A).

But their findings do show a «significant protective effect» of low physical activity on the risk of suspected bacterial infection, they wrote, and of low and moderate activity on the risk of UTIs specifically.