Sentences with phrase «showing aberrant»

The numerator represents the number of animals which were hypothyroid and the denominator the number showing aberrant behavior.

Section of a stomach cancer (seen under a microscope) showing aberrant expression of YBX1 protein (stained brown).

Transformed cells such as the Jurkat line may show aberrant DNA methylation patterns at specific loci [57], possibly complicating analyses of cytosine methylation and HIV - 1 latency.

Aggressive Male Juvenile Offenders with Callous - Unemotional Traits Show Aberrant Attentional Orienting to Distress Cues.

Not exact matches

University of California, Irvine neurobiologists Leslie Thompson and Joseph Ochaba with the Departments of Neurobiology & Behavior and Psychiatry & Human Behavior and their colleagues from UCI and from Children's Hospital of Philadelphia have shown that reducing the aberrant accumulation of a particular form of the mutant Huntingtin protein corresponds to improvement in symptoms and neuroinflammation in HD mice.

The scientists have shown that, in all cancers, a sort of «identity crisis» is observed in cancerous cells: in the organs or tissues in which a tumor develops, genes specific to other tissues or to other stages of the development of the organism express themselves in an aberrant manner.

The scientists have shown that, in all cancers, an aberrant activation of numerous genes specific to other tissues occurs.

«Our organotypic models demonstrate the power of the microenvironment by showing that normal cells in their native architecture naturally steer fully malignant, genotypically aberrant tumor cells into a quiescent state,» Ghajar says.

Star - shaped brain cells known as astrocytes aid perform many indispensible functions, but a new study shows that an aberrant version of the cells may contribute to many neurodegenerative diseases.

Blood founder cells showed a much lower propensity for aberrant methylation than did other founder cells, which could explain why in the past scientists attributed the founder cell to the effectiveness of differentiating iPS cells to the hematopoietic lineage.

The other marker is an aberrant pattern in the chromosomes; the DNA shows a greater number of abnormalities than normal, including DNA that is missing or moved.

«What is exciting about this study is that it goes beyond correlation and shows causation, because we demonstrated for the first time that aberrant expression of this protein is sufficient to induce pathology.»

Studies have shown that magnetic resonance imaging, positron - emission tomography and spinal taps — and newer methods now in the lab — can detect the effects of the buildup of aberrant proteins characteristic of Alzheimer's some 10 to 15 years before the first symptoms appear.

This is in accordance with previous reports that decitabine and 5 - azacytidine produce a marked synergistic effect in combination with suberoylanilide hydroxamic acid and romidepsin in T - lymphoma cell lines by modulating cell cycle arrest and apoptosis.26, 27 As a mechanism of action, KMT2D mutations of B - lymphoma cells promote malignant outgrowth by perturbing methylation of H3K4 that affect the JAK - STAT, Toll - like receptor, or B - cell receptor pathway.28, 29 Here our study indicated that dual treatment with chidamide and decitabine enhanced the interaction of KMT2D with the transcription factor PU.1, thereby inactivating the H3K4me - associated signaling pathway MAPK, which is constitutively activated in T - cell lymphoma.13, 30,31 The transcription factor PU.1 is involved in the development of all hematopoietic lineages32 and regulates lymphoid cell growth and transformation.33 Aberrant PU.1 expression promotes acute myeloid leukemia and is related to the pathogenesis of multiple myeloma via the MAPK pathway.34, 35 On the other hand, PU.1 is also shown to interact with chromatin remodeler and DNA methyltransferease to control hematopoiesis and suppress leukemia.36 Our data thus suggested that the combined action of chidamide and decitabine may interfere with the differentiation and / or viability of PTCL - NOS through a PU.1 - dependent gene expression program.

RNA - seq analysis detected aberrant splicing in DONSON due to one of these noncoding variants, showing a causative role for DONSON disruption in MMS.

«The data show that aberrant epigenetic gene programming can now be considered a hallmark of acute lymphoblastic leukemia, occurring in all patients regardless of the presence of genetic mutations,» Melnick said.

This study shows for the first time proteins interacting with Nbeal2 and points to the dysregulation of the canonical signaling pathway of Dock7 as a possible cause of the aberrant formation of platelets in GPS cases and Nbeal2 deficient mice.

Clips from his films (along with other key works of the era) are shown in the documentary, offering a small glimpse into his aberrant and visionary classics.

In dogs with aberrant aggression, a large collaborative study at Tufts University has shown a favorable response to thyroid replacement therapy within the first week of treatment, whereas it took about three weeks to correct their metabolic deficit.

In this group show tracing aberrant and outsider youth cultures since the 1950s, the themes are gender, sexuality, drug - taking, gangs and rebellion.

As for the exhibition itinerary, it's aberrant, like that of Venice itself, and seeing the show in its entirety comes close to moving through an obstacle course.