Not exact matches
Decreased
synaptic activity would
show that sleep pruned unnecessary memory connections, whereas memory consolidation would have a different pattern.
This finding is in accordance with earlier animal model studies, which have
shown that physical
activity increases the amount of growth factors in the brain and improves
synaptic plasticity.
They used a somewhat bizarre technique in which two mice were sutured together in such as way that they shared a circulatory system (known as parabiosis), and found old mice joined to their youthful counterparts
showed changes in gene
activity in a brain region called the hippocampus as well as increased neural connections and enhanced «
synaptic plasticity» — a mechanism believed to underlie learning and memory in which the strength of neural connections change in response to experience.
«This work
shows that dendritic spines, which are sub-micrometer compartments within individual neurons, are the prime candidates for the initial tag of transient, millisecond
synaptic activity that eventually orchestrates memory traces in the brain lasting tens of years,» said Shahid Khan, senior scientist at the Molecular Biology Consortium at Lawrence Berkeley National Laboratory and a co-author on the PNAS paper.