Sentences with phrase «shown by antibody»

Not exact matches

First clinical trials with a Sclerostin - inhibiting antibody developed by the companies Amgen and UCB showed promising results in that the bone mass of participants suffering from osteoporosis increased.

Researchers used tissue and blood samples to show that the gammopathy (a precursor to myeloma) in both mice and patients with Gaucher disease is triggered by specific lipids, and that the antibodies made by tumor cells in nearly a third of myeloma patients are directed against such lipids.

She has created toxin - smothering antibodies that have been shown to be safe in humans by Caprion Pharmaceuticals, paving the way for efficacy trials.

They started by analyzing x-ray crystal structures that show in atomic detail how flu - binding antibodies in people grab on to the three sugar - binding sites on HA's head.

His team also confirmed pig - to - human Ebola transmission by identifying six pig handlers, whose blood tested positive for antibodies to the virus, although they showed no symptoms.

By the time patients show up and get blood work done, the virus is often no longer detectable and the antibodies that could be picked up by a CDC lab may look like those for the more common denguBy the time patients show up and get blood work done, the virus is often no longer detectable and the antibodies that could be picked up by a CDC lab may look like those for the more common denguby a CDC lab may look like those for the more common dengue.

The researchers also showed that the antibodies induced by the trivalent vaccine potently neutralized four isolates of HSV2 from sub-Saharan Africa, where infection prevalence is very high.

«We've shown that a specific type of these cells, known as follicular helper T (Tfh) cells are not only necessary, but are a limiting factor that differentiates between an average and a potent antibody response to HIV,» says Crotty, a scientific collaborator with the Center for HIV / AIDS Vaccine Immunology & Immunogen Discovery (CHAVI - ID), a major research consortium led by The Scripps Research Institute.

A randomized phase III trial finding that a new monoclonal antibody, elotuzumab, added to standard therapy, extended the duration of remission for patients with relapsed multiple myeloma by about five months Findings from two phase III studies showing that children with Wilms tumor who have a specific chromosomal abnormality do better with a more intensive, augmented chemotherapy regimen

-- Hyperimmune globulin, prepared by purifying and concentrating plasma of immunized animals or previously infected humans with high titers (concentrations) of neutralizing antibody against Ebola virus, which have been shown to be protective in monkeys but are not currently available and would not be expected before mid-2015.

Complexes with HAs from the group 1 H1 and the group 2 H3 subtypes analyzed by x-ray crystallography showed that the antibody bound to a conserved epitope in the F subdomain.

One of the best things mothers - to - be can do to keep their newborns healthy, the study shows, is to themselves deliver those antibodies to their babies by getting vaccinated during pregnancy.

Follow - up studies showed that the two antibodies isolated from the Ebola patient work by interfering with a critical step in the process by which ebolaviruses infect cells and then multiply inside them.

By longitudinal analysis blood samples retrieved from persons who have received the Ebola vaccine, the researchers could show that a group of cytokines measured in plasma within seven days of the vaccine injection correlates with antibody responses developed six months later.

They confirmed this by showing that tumor growth was reduced in mice treated with an antibody drug that targets TIM - 3 and the chemotherapy agent paclitaxel, as compared to treatment with paclitaxel alone.

«Our study sounds a serious warning about the possible detrimental side effects of this strategy, since we have shown that such antibodies cause dramatic degeneration of nerve cells by interfering with the normal on - off function of the prion protein,» he added.

Previous laboratory studies have shown that antibodies produced by the human immune system to fight dengue virus can also interact with Zika virus (ZIKV) without inactivating it.

But clinical tests of novel H1N1 vaccines published online yesterday by The New England Journal of Medicine show that a single dose can trigger high levels of antibodies in adults.

Researchers assumed that African rodents must have their own menagerie of hantaviruses and that these might infect humans as well — an idea supported by studies that showed that some Africans carry antibodies that cross-react with Eurasian hantaviruses.

However, the researchers showed that a new antibody, called BI-1206, can effectively prevent this drug destruction process and enhance cancer killing by binding to a molecule called FcγRIIB.

The researchers, who were funded by Leukemia & Lymphoma Research and Cancer Research UK, have shown that some cancer cells are able to draw monoclonal antibodies inside themselves, making them invisible to immune cells.

Groundbreaking findings, published online in the journal journal Cancer Cell, show that resistance to many types of antibody drugs can be overcome by preventing cancer cells from «hiding» from immune cells.

By cloning rat melanopsin and generating specific antibodies, we show that melanopsin is present in cell bodies, dendrites, and proximal axonal segments of a subset of rat RGCs.

They show that highly purified NS1 acts as a pathogen - associated molecular pattern (PAMP) that activates mouse macrophages and human peripheral blood mononuclear cells (PBMCs) in culture via TLR4, resulting in release of inflammatory cytokines — an effect that was blocked by either a TLR4 antagonist or an anti-TLR4 antibody.

In a paper appearing in the journal ChemBioChem, Pentelute and colleagues showed that they could use this disarmed version of the anthrax toxin to deliver two proteins known as antibody mimics, which can kill cancer cells by disrupting specific proteins inside the cells.

Avidities for these mAbs and for the antibodies that did not neutralize infection in vitro were estimated by Scatchard plot analyses of ELISA data (shown in parentheses).

Infected mice were already showing measurable weight loss that was reversed by administration of the antibody, demonstrating therapeutic potential even after the onset of disease.

Quantification of aggregates by image analysis of slides stained with anti-IAPP antibodies (Fig. 6 C) and ThS (Fig. 6 D) showed a twofold greater burden of IAPP deposits in mice inoculated with synthetic aggregates, as compared with the PBS - treated controls and the animals injected with nonaggregated IAPP.

«We have experiments in mice that show that the combined use of PD - 1 antibody and poly - IC is synergistic for the recognition of tumors and an antitumor response mediated by T - cells,» says Dr. Esteban Celis, co-leader of the Cancer Immunology, Inflammation and Tolerance program at the Georgia Cancer Center at Augusta University.

Similarly, by studying actin regulators such as Cdc42 or Nck we have shown that they play a major role in B cell activation and antibody production (Burbage et al. 2014; Castello et al. 2013).

An anti-PD-1 antibody developed by Bristol - Myers Squibb generates excitement with results from a phase I trial showing that, among 236 patients with various types of cancer, the treatment shrank tumors in 28 percent of melanoma patients, 30 percent of patients with kidney cancer, and 18 percent of patients with advanced non-small cell lung cancer.

While much recent research has not been published in this area, there is actually a long history of studies that show: (1) there is a significant number of antigens shared between tumors and embryonic tissues (called «oncofetal antigens») and, consequently, antibodies made against tumors can also recognize embryonic tissues, and vice versa; (2) pregnancy confers some immunity against cancer (accompanied by antibody production against oncofetal antigens), not only against its occurrence but also against its growth; (3) similar to pregnancy, an immune response against cancer can be generated by vaccinating animals with embryonic tissues.

However, Williams and colleagues now show that other proteins are mistakenly identified as ERbeta by non-validated antibodies.

The trials would be for proof of concept, to show whether researchers can, for the first time in humans, stimulate the right B cells to start the process of making broadly neutralizing antibodies, long considered the «holy grail» of HIV vaccine research because they defend against infection by a broad spectrum of HIV strains.

The data show the DNA / rAd5 vaccination regimen was safe and induced HIV type 1 multi-clade T cell responses, which were not significantly affected by titers of preexisting rAd5 neutralizing antibody.

In the study, the investigators, led by Dr. Marina Caskey, show that this antibody was well tolerated and the antibody lowered the levels of HIV virus in the circulation of the research participants.

Keiran's image shows the morphology of the neuron as visualised by staining with an antibody against bIII - tubulin (blue).

In addition, we observed evidence of persistent, intact, metabolically - active B. burgdorferi after antibiotic treatment of disseminated infection and showed that persistence may not be reflected by maintenance of specific antibody production by the host.

Ahmedâ $ ™ s team had showed that people infected by the 2009 H1N1 flu strain developed broadly protective antibodies, and separately, so did volunteers immunized against the H5N1 avian flu virus.

The researchers used an antibody that labels the proteins made by two closely linked homeotic genes, Ubx and abdA, to show in which segments of the embryo the genes are turned on.

One year follow - up revealed that AN1792 antibody responders showed improvements in cognitive measures as assessed by the neuropsychological test battery (NTB) and a decrease in brain volume compared with placebo.

This approach was pioneered by CRI's Scientific Advisory Council director James P. Allison, Ph.D., who was the first to show that an antibody that blocked a molecule called CTLA - 4 on T cells could lead to cancer regressions in mice.

By combining checkpoint blockade with an anti-CD27 antibody, we have been able to show that the two approaches can be harnessed to potentially improve current treatment options.»

We used a new WB assay to test for anti-XMRV antibodies and showed by using both monoclonal antibodies and polyclonal antisera that this assay detected specifically, and with high titers, reactivity to both XMRV and MuLV Gag and Env proteins.

Confocal fluorescent, confocal scattering images of prostate cancer C4 - 2B (A, B) and stromal HS - 5 (D, E) cells: (A, D)- confocal fluorescent images of AlexaFluor488 conjugated to PSMA antibody, (B, E)- confocal scattering images of gold NPs clusters (shown in red on the green fluorescent background that shows cell tracker dye) and (C, F) the corresponding profiles of scattering signal amplitudes by gold NPs clusters in cells.

This anti-PD-1 antibody works in a complementary fashion to ipilimumab and can be combined with it for more powerful results, as has been recently shown by a clinical trial conducted by CRI Scientific Advisory Council associate director Jedd Wolchok.

Our conclusion that LFA1 and ICAM1 function during innate - like lymphocyte movement from the SCS into the LN parenchyma is based on four sets of observations in mice treated with αL blocking antibody: (1) innate - like lymphocytes transiently accumulate in the SCS; (2) the accumulated cells exhibit an unusual elongated morphology (suggesting a less adhesive state); (3) tracking analysis shows reduced numbers of cells migrating from the SCS into the parenchyma; (4) the cells are more sensitive to dislodgement by CD169 blocking antibody.

Their results show that the original idea is correct and that such antibody treatment does actually stop the channels from opening, with one very important exception: the MEK channel was actually powerfully stimulated by the treatment — the antibodies being as effective in this as the hormone itself — and actively helped the cancer cells to survive.

We also had very high levels of anti-gliadin antibodies as well as multiple organ - specific markers showing which organs had already begun to be destroyed by the auto - immune reaction.

Celiac disease — Wheat gluten sensitivity — Enterolabs, Cyrex labs, antigliadin antibody Chronic autoimmune disorders - entire list of autoimmune diseases Chronic hives Cognitive Dysfunction and Dementia from B12 deficiency Dermatitis herpetiformis (herpes)- typical for wheat gluten sensitivity Depression - Leaky Gut with LPS (see articles by Michael Maes) Diabetes — Autoimmune type one Eczema Gall bladder disease — associated with hypochlorhydia Graves disease - Autoimmune - Elevated TSH receptor ab - Yersinia molecular Mimciry with TSH receptor Hepatitis Iron deficiency - Low Iron and Low ferritin Hyper and hypothyroidism - Autoimmune - Hashimotos Thyroiditis Lupus erythematosus - autoimmune Myasthenia gravis Neuropathy and NeuroPsychiatric Disorder from B12 deficiency Osteoporosis - from Calcium Malabsorption Pernicious anemia — Parietal Cell Antibodies - B12 deficiency - gastric atrophy Psoriasis - autoimmune Rheumatoid arthritis - autoimmune Rosacea Sjögren's syndrome — Autoimmune Thyrotoxicosis - three types: Graves, Hashitoxicosis, and Txic Nodular Goiter Vitiligo Chronic intestinal parasites or abnormal flora - GI - Fx shows parasite DNA Undigested food in stool - Demonstrated on GI - FX test Chronic candida infections - from gut dysbiosis Upper digestive tract gassiness - from dysbiosis