By the time this strain of genetically modified mice reaches 9 months of age, the hippocampus — a part of the brain important for memory — typically is visibly shrunken and
shows dying neurons.
Not exact matches
The study, published in Nature Communications,
shows that membralin regulates the cell's machinery for producing beta - amyloid (or amyloid beta, Aβ), the protein that causes
neurons to
die in Alzheimer's disease.
Matthew Rand, a mercury toxicologist at the University of Vermont, has
shown in fruit fly models that mercury binds to cells, including
neurons, and interferes with signals being sent to the cells that control how they develop, replicate, and
die.
This work is based on his previous research
showing that a specific type of
neuron that
dies in Parkinson's disease is more vulnerable to problems in mitochondrial fission.