Sentences with word «sialic»

The nature of sialic acid in mucins also vary in different species, providing more evidence for how species - specific microbiota interactions occur.

- dystroglycan, an integral component of the muscle transmembrane dystrophin - glycoprotein complex, is low in sialic acid in HIBM patients.

In previous work, Anthony's group and others have found that the anti-inflammatory effect of high - dose IVIG can be attributed to a minor fraction of antibodies to which a glycan called sialic acid has been attached to their Fc region.

Adding plausibility, «both autoantigens related to Hashimoto disease [thyroid peroxidase and / or thyroglobulin] are glycoproteins and N - linked carbohydrates containing sialic acids have been detected in both molecules.»

They can absorb sialic acid through contact with animals or by eating food of animal origin and integrate it into their glycoproteins.

If we can remove sialic acid residues from the cell surface, this will force the insulin receptor do its job of absorbing blood sugar properly.

Like different picks in a locksmith's tool, the 17 known subtypes of hemagglutinin, a surface protein on influenza strains, match different sialic acid receptors on a host cell.

Therapy with Ace - ER led to dose - dependent increases in serum sialic acid levels.

Researchers present the first clinical study that provides evidence that an extended - release sialic acid supplement may stabilize muscle strength in patients with GNE myopathy (GNEM), a rare hereditary, progressive, adult - onset muscle disease.

Patients with GNEM have mutations in a gene controlling a key enzyme in the synthesis pathway for sialic acid (SA).

The treatment consists of providing N - acetylmannosamine, which forms sialic acid in the body.

Members of the section are collaborating with investigators from the National Center for Advancing Translational Sciences (NCATS) to treat a late - onset muscle disease called GNE myopathy using sialic acid, whose production is defective in that disorder.

[MR: This is because lack of Neu1 means that it's not available to strip sialic acids from LAMP - 1, and oversialylated LAMP - 1 leads to loss of its inhibitory function over lyso exocytosis, apparently leading to a nonspecific puking out of its contents into the ECF].

HMOs may even make your baby smarter as they provide the infant with sialic acid which shows potential as an essential nutrient for brain development and cognition!

A dietary non-human sialic acid may facilitate hemolytic - uremic syndrome.

When sialic acids are bound by antibodies, the charge is lost, and cells clump or aggregate.

This can happen because some bacteria do incorporate sialic acids from their local environment into their cell walls; and thus gut bacteria will incorporate Neu5Gc from food into cell walls.

Presumably free sialic acid is made available to such pathogens by other, sialidase - expressing bacteria living in the same niche, or... by host sialidases that are activated in the course of inflammation.

To date, the published research on this topic has focused on the possibility of pathogens incorporating Neu5Ac, the primary human sialic acid, from human cells into their cell walls, and subsequently triggering autoimmunity against Neu5Ac.

«We discovered that Neu1, a protein nicknamed after «neuraminidase 1,» turns the absorption of sugar «on» or «off» in body cells, by regulating the amount of sialic acid on the surface of cells,» Dr. Pshezhetsky explains.

Some of these sugars, called sialic acids, help tumors hide from the immune system.

They found that a subtype called IgA1, which has a special tail at one end that contains sialic acids, was the most effective.

Recent studies have shown multiple differences between humans and apes in sialic acid (Sia) biology, including Siglecs (Sia - recognizing - Ig - superfamily lectins).

These modules recognise a specific sugar molecule, sialic acid, which caps the end of mucin glycan chains.

The mucus layers secreted by the body to line the gut show a gradient of sialic - acid - capped mucins, with the concentration rising further along the human gastrointestinal tract.

But even non-microbial molecules can have a protective effect: Immunologists from the University of Zurich have shown that a sialic acid found in farm animals is effective against inflammation of lung tissue.

And secondly, through innate immunity via the sialic acids at the other end of the molecule, which is more of a non-specific, broad - ranging attack.

The fourth ring is sialic acid, a sugar with additional ethylene glycol and carboxylic acid components.

Since the attachment of sialic acid to an Fc group requires the presence of another glycan called galactose, the team created two enzymes termed B4Fc and ST6Fc, which induce the attachment of galactose and sialic acid respectively.

Additional experiments found little evidence that enzyme administration affected antibodies not involved with the specific autoimmune condition and also showed that platelets, which become activated at the site of antibody - driven inflammation, provided the sialic acid and galactose attached to the Fc region by the B4ST6Fc enzyme.

Wilson's laboratory used X-ray crystallography to determine the atomic structures of the H7N9 hemagglutinin protein bound to these sialic acid receptor molecules.

Apparently a virus that binds 2,3 - sialic can nevertheless multiply in mammals» noses after all, a finding echoed last month by scientists in Hong Kong, who found H5N1 replicates well in human nasal cells with no 2,3 sugars.

The unchanged 1918 virus binds to 2,6 - sialic acid, while the ones altered by the researchers bound to 2,3.

However, the CDC results suggest finding out what mutations make H5N1 bind to 2,6 - sialic, as those could make it contagious.

«The cells with 2,3 - sialic acid receptors have been associated with the bronchial mucins,» Tumpey told New Scientist.

Bird flu prefers a sugar called 2,3 - sialic acid.

Flu adapted to mammals attaches better to 2,6 - sialic acid.

He elucidated the basic defects in cystinosis and Salla disease, i.e., deficiencies of the lysosomal membrane transporters that carry cystine and sialic acid, respectively, out of the lysosome.

Her research focuses on disorders of sialic acid metabolism and of lysosome - related organelles.

Sialic acid is a negatively charged sugar localized at the end of glycoconjugate chains on glycoproteins and glycolipids.

Dr. Huizing also studies other sialic acid - related diseases, including sialuria, a progressive disease in which patients produce excess sialic acid.

Oral administration of the sialic acid precursor N - acetyl - mannosamine (ManNAc) partially rescues the kidney defect, allowing the mutant mice to survive.