Sentences with phrase «sialic acid»

[5] Varki A, Gagneux P. Multifarious roles of sialic acids in immunity.

The nature of sialic acid in mucins also vary in different species, providing more evidence for how species - specific microbiota interactions occur.

Like different picks in a locksmith's tool, the 17 known subtypes of hemagglutinin, a surface protein on influenza strains, match different sialic acid receptors on a host cell.

[MR: This is because lack of Neu1 means that it's not available to strip sialic acids from LAMP - 1, and oversialylated LAMP - 1 leads to loss of its inhibitory function over lyso exocytosis, apparently leading to a nonspecific puking out of its contents into the ECF].

«We discovered that Neu1, a protein nicknamed after «neuraminidase 1,» turns the absorption of sugar «on» or «off» in body cells, by regulating the amount of sialic acid on the surface of cells,» Dr. Pshezhetsky explains.

In previous work, Anthony's group and others have found that the anti-inflammatory effect of high - dose IVIG can be attributed to a minor fraction of antibodies to which a glycan called sialic acid has been attached to their Fc region.

Adding plausibility, «both autoantigens related to Hashimoto disease [thyroid peroxidase and / or thyroglobulin] are glycoproteins and N - linked carbohydrates containing sialic acids have been detected in both molecules.»

HMOs may even make your baby smarter as they provide the infant with sialic acid which shows potential as an essential nutrient for brain development and cognition!

They can absorb sialic acid through contact with animals or by eating food of animal origin and integrate it into their glycoproteins.

If we can remove sialic acid residues from the cell surface, this will force the insulin receptor do its job of absorbing blood sugar properly.

Therapy with Ace - ER led to dose - dependent increases in serum sialic acid levels.

Researchers present the first clinical study that provides evidence that an extended - release sialic acid supplement may stabilize muscle strength in patients with GNE myopathy (GNEM), a rare hereditary, progressive, adult - onset muscle disease.

Patients with GNEM have mutations in a gene controlling a key enzyme in the synthesis pathway for sialic acid (SA).

The treatment consists of providing N - acetylmannosamine, which forms sialic acid in the body.

Members of the section are collaborating with investigators from the National Center for Advancing Translational Sciences (NCATS) to treat a late - onset muscle disease called GNE myopathy using sialic acid, whose production is defective in that disorder.

Her research focuses on disorders of sialic acid metabolism and of lysosome - related organelles.

A professor of medicine and cellular and molecular medicine in UCSD's Department of Medicine, Varki is known internationally for his research on the biology of sialic acids as it relates to aspects of human evolution and currently serves as coordinator for the multidisciplinary UCSD Project for Explaining the Origins of Humans.

A dietary non-human sialic acid may facilitate hemolytic - uremic syndrome.

Sialic acid utilization by bacterial pathogens.

When sialic acids are bound by antibodies, the charge is lost, and cells clump or aggregate.

This can happen because some bacteria do incorporate sialic acids from their local environment into their cell walls; and thus gut bacteria will incorporate Neu5Gc from food into cell walls.

Presumably free sialic acid is made available to such pathogens by other, sialidase - expressing bacteria living in the same niche, or... by host sialidases that are activated in the course of inflammation.

To date, the published research on this topic has focused on the possibility of pathogens incorporating Neu5Ac, the primary human sialic acid, from human cells into their cell walls, and subsequently triggering autoimmunity against Neu5Ac.

A primary reason for doing this is that, by coating themselves in sialic acids acquired from their host, they look like a «host cell» and are shielded from immune attack.

«The cells with 2,3 - sialic acid receptors have been associated with the bronchial mucins,» Tumpey told New Scientist.

Some of these sugars, called sialic acids, help tumors hide from the immune system.

They found that a subtype called IgA1, which has a special tail at one end that contains sialic acids, was the most effective.

- dystroglycan, an integral component of the muscle transmembrane dystrophin - glycoprotein complex, is low in sialic acid in HIBM patients.

These modules recognise a specific sugar molecule, sialic acid, which caps the end of mucin glycan chains.

But even non-microbial molecules can have a protective effect: Immunologists from the University of Zurich have shown that a sialic acid found in farm animals is effective against inflammation of lung tissue.

And secondly, through innate immunity via the sialic acids at the other end of the molecule, which is more of a non-specific, broad - ranging attack.

The fourth ring is sialic acid, a sugar with additional ethylene glycol and carboxylic acid components.

Since the attachment of sialic acid to an Fc group requires the presence of another glycan called galactose, the team created two enzymes termed B4Fc and ST6Fc, which induce the attachment of galactose and sialic acid respectively.

Additional experiments found little evidence that enzyme administration affected antibodies not involved with the specific autoimmune condition and also showed that platelets, which become activated at the site of antibody - driven inflammation, provided the sialic acid and galactose attached to the Fc region by the B4ST6Fc enzyme.

Wilson's laboratory used X-ray crystallography to determine the atomic structures of the H7N9 hemagglutinin protein bound to these sialic acid receptor molecules.

The unchanged 1918 virus binds to 2,6 - sialic acid, while the ones altered by the researchers bound to 2,3.

Recent studies have shown multiple differences between humans and apes in sialic acid (Sia) biology, including Siglecs (Sia - recognizing - Ig - superfamily lectins).

Bird flu prefers a sugar called 2,3 - sialic acid.

Flu adapted to mammals attaches better to 2,6 - sialic acid.

He elucidated the basic defects in cystinosis and Salla disease, i.e., deficiencies of the lysosomal membrane transporters that carry cystine and sialic acid, respectively, out of the lysosome.

Sialic acid is a negatively charged sugar localized at the end of glycoconjugate chains on glycoproteins and glycolipids.