The parents and full and half
siblings of an affected dog should not be bred close on the pedigree that produced it and should be bred to mates that do not have a family history of iris coloboma.
The grandparents, normal full - or half -
siblings of the affected dog and full siblings of the parents should be DNA tested if they are to be used for breeding in order to determine their CEA status.
Breeders should also contact owners of
siblings of affected dogs to make sure they are all healthy.
Most veterinarian suggest not to breed affected dogs, their parents,
siblings of affected dogs, as well as offspring of affected dogs.
Geneticists recommend that dogs who produce liver shunt should not be bred again and that
the siblings of an affected dog should also be spayed / neutered.
Not exact matches
First - step relatives (parents, full and half
siblings, and offspring if any)
of affected dogs who will be used for breeding should be tested.
First - step relatives
of affected dogs (parents, full and half
siblings, and offspring) should be bred only to mates with pedigrees as clear
of lymphoma as possible and who have no
affected close relatives.
For example, focusing only on the look
of a particular part
of a
dog may distract the breeder from looking at the
dog's ancestors and
siblings or traits that potentially may negatively
affect the health
of the
dog.
In the single instance where
affected full
siblings were born in separate litters (2
affected dogs in each
of two litters), the age
of first seizure covered a range
of 3 years (18, 31, 39, and 54 months,).
Liz will need DNA from
affected dogs, clinical report from the veterinarian or neurologist who diagnosed, samples from normal
siblings, parents, and grandparents if possible, brief history
of clinical signs and disease progression, and necropsy report if available.
A total
of 22 unaffected purebred GIT
dogs were similarly selected as the least related to each other, but matched pairwise to the
affected dogs (i.e.,
siblings or parents
of affecteds).
The parents, full
siblings, and offspring
of CEA
affected dogs or identified carriers should be tested if they are to be used for breeding.
For cataracts not due to HSF4, owners
of the
affected dog's parents and
siblings and offspring should be notified.
Dogs that have a family history of the HD (affected siblings, cousins, aunts / uncles or nephews / nieces) are more likely to produce HD than dogs which do
Dogs that have a family history
of the HD (
affected siblings, cousins, aunts / uncles or nephews / nieces) are more likely to produce HD than
dogs which do
dogs which do not.
Parents, full or half
siblings, and offspring
of an
affected dog should also be bred to mates from families free
of moderate to severe allergies.