Sentences with phrase «sickle cell patients»

It's a high - tech treatment, and many sickle cell patients are low - income and far from a major medical center, he said.

The ability to safely use half - matching donors (parents, most siblings, and all children of the patient) makes bone marrow transplant an effective option for the majority of sickle cell patients.

The odds of being hospitalized for pain or any reason were about doubled for sickle cell patients with fetal hemoglobin levels of 20 percent or less.

«Conversations with Innovators:» UNC hematologist on promising drug trials for treating painful crises in sickle cell patients - Read More...

• Sickle cell disease affects more than 80,000 people in the U.S. Sickle cell patients can require frequent blood transfusions throughout their lives.

«Conversations with Innovators:» UNC hematologist on promising drug trials for treating painful crises in sickle cell patients -

«Conversations with Innovators:» UNC hematologist on promising drug trials for treating painful crises in sickle cell patients

Researchers also discovered that a little bit of fetal hemoglobin, just over 1 % of a person's total hemoglobin, generally courses through human veins our entire lives and that sickle cell patients who have more than usual, over 15 %, have milder symptoms.

Clinical trials of nitric oxide therapy to ease pain in sickle cell patients have yielded conflicting results, with some patients reporting increased pain.

For the first time, they have corrected the mutation in a proportion of stem cells that is high enough to produce a substantial benefit in sickle cell patients.

I reviewed two cases of sickle cell patients who died during pregnancy.

Not exact matches

The corrected red blood cells needn't replace all of a patient's original sickle cells, said Porteus.

The Porteus team started with human stem cells from the blood of patients with sickle cell disease, corrected the gene mutation using CRISPR and then concentrated the human stem cells so that 90 percent carried the corrected sickle cell gene.

An overabundance of the bacteria Veillonella in the digestive tract may increase pain in patients with sickle cell disease (SCD).

«There is still a lot of work to be done before this approach might be used in the clinic, but we're hopeful that it will pave the way for new kinds of treatment for patients with sickle cell disease.»

The new management guidelines consist of more than 500 specific directions for physicians who are caring for patients with sickle cell disease.

«These national guidelines are directed not just to hematologists but to all medical practitioners who might encounter sickle cell disease patients, to inform them about hydroxyurea and how to best offer general medical care to them,» Dr. Buchanan said.

The findings suggest that the presence of sickle cell trait may explain, at least in part, prior observations of greater doses of anemia medications administered to African - American dialysis patients relative to Caucasian patients.

Although treatment for sickle - cell disease with marrow from related donors is now accepted as a standard of care, treatment with marrow taken from an unrelated donor is still evolving, reserved for only the most seriously sick patients.

«When pain was reported as low, sickle cell disease patients reported higher opioid use if they catastrophized, or focused their thinking on their pain, than if they didn't,» says Finan.

Patients with sickle cell trait received about 13 % more of the medications used to treat anemia than other patients to reach the same level of hemPatients with sickle cell trait received about 13 % more of the medications used to treat anemia than other patients to reach the same level of hempatients to reach the same level of hemoglobin.

Patients with sickle cell disease are commonly prescribed a daily, long - acting painkiller taken at a constant dose, and a short - acting painkiller to be taken as needed for episodes of more severe pain.

The investigators also found that sickle cell trait was slightly more common among dialysis patients, present in 10 % of study participants compared with 6.5 % to 8.7 % in the general African - American population.

As a result of the finding, researchers can also use Mauritian cynomolgus macaques to improve stem cell transplant outcomes for human patients with other blood - related conditions such as leukemia and sickle - cell disease.

«This opens up bone - marrow transplants to virtually any patient out there with a haematological condition» such as leukaemia or sickle - cell anaemia, says John Tisdale, a haematologist at the US National Heart, Lung and Blood Institute in Bethesda, Maryland.

The anti-sickling HSC will be transplanted back into the patient's bone marrow and multiply the corrected cells that make red blood cells without sickling.

«Patients with sickle cell disease have had few therapeutic options.

Low levels of both oxygen and the powerful blood vessel dilator nitric oxide appear to have an unfortunate synergy for patients with sickle cell disease, researchers report.

The new findings and the fact that patients with sickle cell disease have significant variability in their nitric oxide levels — even during a pain crisis — likely explains why, Ikuta said.

A number of new clinical trials aim to take cells from a patient, such as blood cells or immune cells, edit them and transfer them back with new power to undermine diseases like cancer or sickle cell anemia.

In hereditary blood disorders such as sickle cell anaemia, the production of faulty cells leaves the patient extremely weak and anaemic.

Medical support for a single patient with sickle cell disease can run $ 25,000 a year or $ 1 million over a lifetime.

A list of Frequently Asked Questions regarding sickle cell trait for both medical experts and consumers / patients.

In sickle cell disease, a genetic variant causes patients» blood cells to take on a crescent, or sickle, shape, rather than the typical round shape.

«For patients with sickle cell disease, blood donors are a matter of life and death.»

ASH is alarmed about the opioid crisis; however, it is concerned about potential adverse effects that policy changes could have on the administration of necessary and appropriate pain medicine for patients with hematologic conditions such as sickle cell disease (SCD), blood cancers, and other bleeding disorders.

If I do not donate, patients with serious blood diseases, like sickle cell anemia, will die.»

Exciting clinical applications of gene editing include correcting the mutation in the bone marrow stem cells of patients with sickle cell disease or hemophilia.

Researchers at Johns Hopkins have successfully corrected a genetic error in stem cells from patients with sickle cell disease, and then used those cells to grow mature red blood cells, they report.

And Belle is right: Patients with sickle cell disease and other serious blood conditions rely on donors to keep their blood flowing and hearts beating.

The problem for patients with sickle cell disease is that lab - grown stem cells with their genetic material would have the sickle cell defect.

But, he says, «This study shows it may be possible in the not - too - distant future to provide patients with sickle cell disease with an exciting new treatment option.»

The study represents an important step toward more effectively treating certain patients with sickle cell disease who need frequent blood transfusions and currently have few options.

Kenneth Ataga, MD, director of the UNC Comprehensive Sickle Cell Program, was featured in a video by the American Society of Hematology in which he discussed the favorable results of a yearlong clinical trial studying crizanlizumab as a therapy to prevent and treat painful crisis events in patients with sickle cell diSickle Cell Program, was featured in a video by the American Society of Hematology in which he discussed the favorable results of a yearlong clinical trial studying crizanlizumab as a therapy to prevent and treat painful crisis events in patients with sickle cell diseCell Program, was featured in a video by the American Society of Hematology in which he discussed the favorable results of a yearlong clinical trial studying crizanlizumab as a therapy to prevent and treat painful crisis events in patients with sickle cell disickle cell disecell disease.

A «Narcotics Contract» for a Patient With Sickle Cell Disease and Chronic Pain.

The Measure of Sickle Cell Stigma: Initial findings from the Improving Patient Outcomes through Respect and Trust study.

A video - intervention to improve clinician attitudes toward patients with sickle cell disease: the results of a randomized experiment.

«For example, despite matching the ABO blood group antigens during red blood cell (RBC) transfusion, up to 45 percent of chronically transfused patients, such as those with sickle cell disease or thalassemia, develop antibodies to mismatched minor antigens on transfused RBCs; this process is known as alloimmunization.»

An unequal burden: Poor patient — provider communication and sickle cell disease.

From birth to adulthood, we help patients live with sickle cell disease, while we continue to research new cures and better long - term care.